FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093155310> ?p ?o ?g. }

• W2093155310 endingPage "2425" @default.
• W2093155310 startingPage "2414" @default.
• W2093155310 abstract "Levels of marinobufagenin (MBG), an endogenous bufadienolide Na/K-ATPase (NKA) inhibitor, increase in preeclampsia and in NaCl-sensitive hypertension.We tested a 3E9 monoclonal anti-MBG antibody (mAb) for the ability to lower blood pressure (BP) in NaCl-sensitive hypertension and to reverse the preeclampsia-induced inhibition of erythrocyte NKA. Measurements of MBG were performed via immunoassay based on 4G4 anti-MBG mAb.In hypertensive Dahl-S rats, intraperitoneal administration of 50 microg/kg 3E9 mAb lowered BP by 32 mmHg and activated the Na/K-pump in the thoracic aorta by 51%. NaCl supplementation of pregnant rats (n = 16) produced a 37 mmHg increase in BP, a 3.5-fold rise in MBG excretion, and a 25% inhibition of the Na/K-pump in the thoracic aorta, compared with pregnant rats on a normal NaCl intake. In eight pregnant hypertensive rats, 3E9 mAb reduced the BP (21 mmHg) and restored the vascular Na/K-pump. In 14 patients with preeclampsia (mean BP, 126 +/- 3 mmHg; 26.9 +/- 1.4 years; gestational age, 37 +/- 0.8 weeks), plasma MBG was increased three-fold and erythrocyte NKA was inhibited compared with that of 12 normotensive pregnant women (mean BP, 71 +/- 3 mmHg) (1.5 +/- 0.1 vs. 3.1 +/- 0.2 micromol Pi/ml/h, respectively; P < 0.01). Ex-vivo 3E9 mAb restored NKA activity in erythrocytes from patients with preeclampsia. As compared with 3E9 mAb, Digibind, an affinity-purified antidigoxin antibody, was less active with respect to lowering BP in both hypertensive models and to restoration of NKA from erythrocytes from patients with preeclampsia.Anti-MBG mAbs may be a useful tool in studies of MBG in vitro and in vivo and may offer treatment of preeclampsia." @default.
• W2093155310 created "2016-06-24" @default.
• W2093155310 creator A5002449947 @default.
• W2093155310 creator A5008680275 @default.
• W2093155310 creator A5014944442 @default.
• W2093155310 creator A5015556456 @default.
• W2093155310 creator A5024016018 @default.
• W2093155310 creator A5027273627 @default.
• W2093155310 creator A5032589511 @default.
• W2093155310 creator A5039707350 @default.
• W2093155310 creator A5055977145 @default.
• W2093155310 creator A5058825789 @default.
• W2093155310 creator A5060742163 @default.
• W2093155310 creator A5065699716 @default.
• W2093155310 creator A5077324000 @default.
• W2093155310 creator A5087358979 @default.
• W2093155310 creator A5077332299 @default.
• W2093155310 date "2008-12-01" @default.
• W2093155310 modified "2023-10-17" @default.
• W2093155310 title "Monoclonal antibody to an endogenous bufadienolide, marinobufagenin, reverses preeclampsia-induced Na/K-ATPase inhibition and lowers blood pressure in NaCl-sensitive hypertension" @default.
• W2093155310 cites W1967454146 @default.
• W2093155310 cites W1968185983 @default.
• W2093155310 cites W1968382041 @default.
• W2093155310 cites W1976270302 @default.
• W2093155310 cites W1979780428 @default.
• W2093155310 cites W1982947530 @default.
• W2093155310 cites W1987534461 @default.
• W2093155310 cites W1996510966 @default.
• W2093155310 cites W1998290030 @default.
• W2093155310 cites W2002119373 @default.
• W2093155310 cites W2019897658 @default.
• W2093155310 cites W2041694632 @default.
• W2093155310 cites W2046924003 @default.
• W2093155310 cites W2047390875 @default.
• W2093155310 cites W2052570675 @default.
• W2093155310 cites W2057800632 @default.
• W2093155310 cites W2069595524 @default.
• W2093155310 cites W2080057691 @default.
• W2093155310 cites W2083467450 @default.
• W2093155310 cites W2087031587 @default.
• W2093155310 cites W2113784050 @default.
• W2093155310 cites W2119860659 @default.
• W2093155310 cites W2121020585 @default.
• W2093155310 cites W2134912211 @default.
• W2093155310 cites W2142744581 @default.
• W2093155310 cites W2145568527 @default.
• W2093155310 cites W2149584537 @default.
• W2093155310 cites W2324881774 @default.
• W2093155310 cites W2417975207 @default.
• W2093155310 cites W4211054086 @default.
• W2093155310 doi "https://doi.org/10.1097/hjh.0b013e328312c86a" @default.
• W2093155310 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2583455" @default.
• W2093155310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19008721" @default.
• W2093155310 hasPublicationYear "2008" @default.
• W2093155310 type Work @default.
• W2093155310 sameAs 2093155310 @default.
• W2093155310 citedByCount "74" @default.
• W2093155310 countsByYear W20931553102012 @default.
• W2093155310 countsByYear W20931553102013 @default.
• W2093155310 countsByYear W20931553102014 @default.
• W2093155310 countsByYear W20931553102015 @default.
• W2093155310 countsByYear W20931553102016 @default.
• W2093155310 countsByYear W20931553102017 @default.
• W2093155310 countsByYear W20931553102018 @default.
• W2093155310 countsByYear W20931553102019 @default.
• W2093155310 countsByYear W20931553102020 @default.
• W2093155310 countsByYear W20931553102021 @default.
• W2093155310 countsByYear W20931553102022 @default.
• W2093155310 countsByYear W20931553102023 @default.
• W2093155310 crossrefType "journal-article" @default.
• W2093155310 hasAuthorship W2093155310A5002449947 @default.
• W2093155310 hasAuthorship W2093155310A5008680275 @default.
• W2093155310 hasAuthorship W2093155310A5014944442 @default.
• W2093155310 hasAuthorship W2093155310A5015556456 @default.
• W2093155310 hasAuthorship W2093155310A5024016018 @default.
• W2093155310 hasAuthorship W2093155310A5027273627 @default.
• W2093155310 hasAuthorship W2093155310A5032589511 @default.
• W2093155310 hasAuthorship W2093155310A5039707350 @default.
• W2093155310 hasAuthorship W2093155310A5055977145 @default.
• W2093155310 hasAuthorship W2093155310A5058825789 @default.
• W2093155310 hasAuthorship W2093155310A5060742163 @default.
• W2093155310 hasAuthorship W2093155310A5065699716 @default.
• W2093155310 hasAuthorship W2093155310A5077324000 @default.
• W2093155310 hasAuthorship W2093155310A5077332299 @default.
• W2093155310 hasAuthorship W2093155310A5087358979 @default.
• W2093155310 hasBestOaLocation W20931553101 @default.
• W2093155310 hasConcept C10146269 @default.
• W2093155310 hasConcept C126322002 @default.
• W2093155310 hasConcept C134018914 @default.
• W2093155310 hasConcept C159654299 @default.
• W2093155310 hasConcept C16613235 @default.
• W2093155310 hasConcept C203014093 @default.
• W2093155310 hasConcept C2777218350 @default.
• W2093155310 hasConcept C2779234561 @default.
• W2093155310 hasConcept C542903549 @default.
• W2093155310 hasConcept C54355233 @default.
• W2093155310 hasConcept C71924100 @default.
• W2093155310 hasConcept C84393581 @default.

• next