Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093157788> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2093157788 endingPage "493" @default.
- W2093157788 startingPage "491" @default.
- W2093157788 abstract "During reperfusion, the heart undergoes damage characterised by excessive production of reactive oxygen species (ROS), which may be generated by mitochondrial protein synthesis or the activity of cardiac cytochrome P450 enzymes (CYPs). Chloramphenicol inhibits both mitochondrial protein synthesis and the activity of CYPs, and in the perfused rat model of ischaemia/reperfusion, it decreased the release of creatine kinase and infarct size. This cardioprotective effect of chloramphenicol was not associated with mitochondrial protein synthesis, implicating the inhibition of CYPs in the cardioprotection. The ROS superoxide was generated by the heart in ischaemia/reperfusion, and this generation was inhibited by chloramphenicol. Inhibitors of CYP2C9 with no effect on mitochondrial protein synthesis, such as cimetidine and sulfaphenazole, are also cardioprotective in the perfused rat heart. Inhibition of CYP2C9 is a promising approach for the treatment of myocardial infarction, and should be further developed." @default.
- W2093157788 created "2016-06-24" @default.
- W2093157788 creator A5071085963 @default.
- W2093157788 date "2004-10-01" @default.
- W2093157788 modified "2023-09-25" @default.
- W2093157788 title "Inhibition of cardiac cytochrome P450: a new approach to cardiac ischaemia and reperfusion damage" @default.
- W2093157788 cites W1964809898 @default.
- W2093157788 cites W1982135265 @default.
- W2093157788 cites W1983820161 @default.
- W2093157788 cites W1988338920 @default.
- W2093157788 cites W2032929177 @default.
- W2093157788 cites W2042373322 @default.
- W2093157788 cites W2058994971 @default.
- W2093157788 cites W2073597770 @default.
- W2093157788 cites W2129522776 @default.
- W2093157788 cites W2157646577 @default.
- W2093157788 cites W4234947744 @default.
- W2093157788 doi "https://doi.org/10.1517/14728222.8.5.491" @default.
- W2093157788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15469397" @default.
- W2093157788 hasPublicationYear "2004" @default.
- W2093157788 type Work @default.
- W2093157788 sameAs 2093157788 @default.
- W2093157788 citedByCount "6" @default.
- W2093157788 countsByYear W20931577882012 @default.
- W2093157788 countsByYear W20931577882020 @default.
- W2093157788 crossrefType "journal-article" @default.
- W2093157788 hasAuthorship W2093157788A5071085963 @default.
- W2093157788 hasConcept C126322002 @default.
- W2093157788 hasConcept C185592680 @default.
- W2093157788 hasConcept C2779676291 @default.
- W2093157788 hasConcept C2780114680 @default.
- W2093157788 hasConcept C28859421 @default.
- W2093157788 hasConcept C29311851 @default.
- W2093157788 hasConcept C36880943 @default.
- W2093157788 hasConcept C48349386 @default.
- W2093157788 hasConcept C541997718 @default.
- W2093157788 hasConcept C55493867 @default.
- W2093157788 hasConcept C71924100 @default.
- W2093157788 hasConcept C86803240 @default.
- W2093157788 hasConcept C98274493 @default.
- W2093157788 hasConceptScore W2093157788C126322002 @default.
- W2093157788 hasConceptScore W2093157788C185592680 @default.
- W2093157788 hasConceptScore W2093157788C2779676291 @default.
- W2093157788 hasConceptScore W2093157788C2780114680 @default.
- W2093157788 hasConceptScore W2093157788C28859421 @default.
- W2093157788 hasConceptScore W2093157788C29311851 @default.
- W2093157788 hasConceptScore W2093157788C36880943 @default.
- W2093157788 hasConceptScore W2093157788C48349386 @default.
- W2093157788 hasConceptScore W2093157788C541997718 @default.
- W2093157788 hasConceptScore W2093157788C55493867 @default.
- W2093157788 hasConceptScore W2093157788C71924100 @default.
- W2093157788 hasConceptScore W2093157788C86803240 @default.
- W2093157788 hasConceptScore W2093157788C98274493 @default.
- W2093157788 hasIssue "5" @default.
- W2093157788 hasLocation W20931577881 @default.
- W2093157788 hasLocation W20931577882 @default.
- W2093157788 hasOpenAccess W2093157788 @default.
- W2093157788 hasPrimaryLocation W20931577881 @default.
- W2093157788 hasRelatedWork W1982007667 @default.
- W2093157788 hasRelatedWork W2139141364 @default.
- W2093157788 hasRelatedWork W2314976951 @default.
- W2093157788 hasRelatedWork W2340330396 @default.
- W2093157788 hasRelatedWork W2409872084 @default.
- W2093157788 hasRelatedWork W2415509219 @default.
- W2093157788 hasRelatedWork W2609160282 @default.
- W2093157788 hasRelatedWork W3023456303 @default.
- W2093157788 hasRelatedWork W3030270935 @default.
- W2093157788 hasRelatedWork W99788924 @default.
- W2093157788 hasVolume "8" @default.
- W2093157788 isParatext "false" @default.
- W2093157788 isRetracted "false" @default.
- W2093157788 magId "2093157788" @default.
- W2093157788 workType "article" @default.