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• W2093164024 abstract "La cirrosis biliar primaria (CBP) es una enfermedad hepática colestásica crónica, que se caracteriza por lesión inflamatoria y destrucción de conductos biliares. Estudios recientes indican que Chlamydia pneumoniae podría estar asociada al desarrollo de CBP. El objetivo de este estudio ha sido determinar la seroprevalencia de C. pneumoniae en una cohorte de pacientes con CBP. Se buscaron anticuerpos antiinmunoglobulina G contra C. pneumoniae en 46 pacientes con CBP y 105 sujetos sin cirrosis hepática. Entre los pacientes con CBP, 21 (46%) tuvieron anticuerpos, en comparación con 74 (71%) del grupo control, con una odds ratio de 0,6 (intervalo de confizanza del 95%, 0,3-1,2; p no significativa). El subanálisis del grupo con CBP mostró que los pacientes seropositivos presentaron mayor frecuencia de estadios avanzados de Child-Pugh (el 24% A, el 52% B y el 24% C, frente a un 64% A, un 32% B y un 4% C; p = 0,01), mayor puntuación en la escala pronóstica de la Clínica Mayo (7,8 ± 2,1 frente a 5,6 ± 1,2; p = 0,004), mayor frecuencia de ascitis (un 29 frente a un 4%; odds ratio de 9,6; intervalo de confianza del 95%, 1,1-87; p = 0,02), concentraciones mayores de bilirrubina total (4,5 ± 2,5 frente a 2,4 ± 4,3 mg/dl; p = 0,001) y valores menores de albúmina (2,6 ± 0,9 frente a 3,3 ± 0,6 g/dl; p = 0,02). No fue posible establecer una asociación entre C. pneumoniae y CBP. Encontramos una relación entre la gravedad de la CBP y la seropositividad para C. pneumoniae, lo que podría apuntar a un efecto perjudicial de esta infección o bien a una predisposición en etapas avanzadas para adquirir infecciones por C. pneumoniae. Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease characterized by inflammatory injury and bile duct destruction. Recent studies suggest that Chlamydia pneumoniae could be associated with the development of PBC. The aim of this study was to determine the seroprevalence of C. pneumoniae in a cohort of patients with PBC. The presence of IgG antibodies against C. pneumoniae was investigated in 46 patients with PBC and in 105 subjects without cirrhosis. Twenty-one patients (46%) with PBC had antibodies against C. pneumoniae compared with 74 subjects (71%) in the control group (OR = 0.6; 95% CI, 0.3-1.2; p = NS). Subanalysis of the PBC group showed that patients with C. pneumoniae antibodies had a higher frequency of advanced Child-Pugh stages (24% A, 52% B and 24% C vs 64% A, 32% B and 4% C; p = 0.01), a higher score on the Mayo Clinic Prognostic Index (7.8 ± 2.1 vs 5.6 ± 1.2; p = 0.004), a higher frequency of ascites (29% vs 4%; OR = 9.6; 95% CI, 1-87; p = 0.02), higher total bilirubin levels (4.5 ± 2.5 mg/dl vs 2.4 ± 4.3 mg/dl, p = 0.001) and lower serum albumin levels (2.6 ± 0.9 g/dl vs 3.3 ± 0.6 g/dl, p = 0.02). No association was found between C. pneumoniae infection and PBC in this study. An association was found between the severity of PBC and C. pneumoniae, which may suggest a deleterious effect of C. pneumoniae infection or a predisposition in advanced stages of PBC to acquire infection with this microorganism." @default.
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• W2093164024 date "2006-03-01" @default.
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• W2093164024 title "Seropositividad para Chlamydia pneumoniae en pacientes con cirrosis biliar primaria" @default.
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• W2093164024 doi "https://doi.org/10.1157/13085138" @default.
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