FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093178404> ?p ?o ?g. }

• W2093178404 endingPage "254" @default.
• W2093178404 startingPage "245" @default.
• W2093178404 abstract "SUMMARY The recent reduction in the efficacy of azole fungicides in controlling Septoria leaf blotch of wheat, caused by Mycosphaerella graminicola, has prompted concerns over possible development of resistance, particularly in light of the recent emergence of widespread resistance to quinone outside inhibitors (QoIs). We have recently implicated alterations in the target-encoding sterol 14alpha-demethylase protein (CYP51), and over-expression of genes encoding efflux pumps, in reducing sensitivity to the azole class of sterol demethylation inhibitors (DMIs) in M. graminicola. Here we report on the prevalence and selection of two CYP51 alterations, substitution I381V and deletion of codons 459 and 460 (DeltaY459/G460), in populations of M. graminicola. Neither alteration has previously been identified in human or plant pathogenic fungi resistant to azoles. The presence of DeltaY459/G460 showed a continuous distribution of EC(50) values across isolates with either I381 or V381, and had no measurable effect on azole sensitivity. Data linking fungicide sensitivity with the presence of I381V in M. graminicola show for the first time that a particular CYP51 alteration is differentially selected by different azoles in field populations of a plant pathogen. Substitution I381V although not an absolute requirement for reduced azole sensitivity, is selected by tebuconazole and difenoconazole treatment, suggesting an adaptive advantage in the presence of these two compounds. Prochloraz treatments appeared to select negatively for I381V, whereas other azole treatments did not or only weakly impacted on the prevalence of this substitution. These findings suggest treatments with different members of the azole class of fungicides could offer a resistance management strategy." @default.
• W2093178404 created "2016-06-24" @default.
• W2093178404 creator A5005929398 @default.
• W2093178404 creator A5007741614 @default.
• W2093178404 creator A5019166579 @default.
• W2093178404 creator A5021544084 @default.
• W2093178404 creator A5041461719 @default.
• W2093178404 creator A5069154294 @default.
• W2093178404 date "2007-05-01" @default.
• W2093178404 modified "2023-10-14" @default.
• W2093178404 title "A novel substitution I381V in the sterol 14?-demethylase (CYP51) of Mycosphaerella graminicola is differentially selected by azole fungicides" @default.
• W2093178404 cites W118611557 @default.
• W2093178404 cites W1905535572 @default.
• W2093178404 cites W1971544925 @default.
• W2093178404 cites W1983225412 @default.
• W2093178404 cites W1999042939 @default.
• W2093178404 cites W2010187909 @default.
• W2093178404 cites W2012412299 @default.
• W2093178404 cites W2024384997 @default.
• W2093178404 cites W2036520390 @default.
• W2093178404 cites W2038990788 @default.
• W2093178404 cites W2046257159 @default.
• W2093178404 cites W2073439032 @default.
• W2093178404 cites W2075437124 @default.
• W2093178404 cites W2087964747 @default.
• W2093178404 cites W2091101839 @default.
• W2093178404 cites W2106289382 @default.
• W2093178404 cites W2106411950 @default.
• W2093178404 cites W2125995480 @default.
• W2093178404 cites W2131189136 @default.
• W2093178404 cites W2135021455 @default.
• W2093178404 cites W2138581730 @default.
• W2093178404 cites W2147757952 @default.
• W2093178404 cites W2158978828 @default.
• W2093178404 doi "https://doi.org/10.1111/j.1364-3703.2007.00388.x" @default.
• W2093178404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20507496" @default.
• W2093178404 hasPublicationYear "2007" @default.
• W2093178404 type Work @default.
• W2093178404 sameAs 2093178404 @default.
• W2093178404 citedByCount "122" @default.
• W2093178404 countsByYear W20931784042012 @default.
• W2093178404 countsByYear W20931784042013 @default.
• W2093178404 countsByYear W20931784042014 @default.
• W2093178404 countsByYear W20931784042015 @default.
• W2093178404 countsByYear W20931784042016 @default.
• W2093178404 countsByYear W20931784042017 @default.
• W2093178404 countsByYear W20931784042018 @default.
• W2093178404 countsByYear W20931784042019 @default.
• W2093178404 countsByYear W20931784042020 @default.
• W2093178404 countsByYear W20931784042021 @default.
• W2093178404 countsByYear W20931784042022 @default.
• W2093178404 countsByYear W20931784042023 @default.
• W2093178404 crossrefType "journal-article" @default.
• W2093178404 hasAuthorship W2093178404A5005929398 @default.
• W2093178404 hasAuthorship W2093178404A5007741614 @default.
• W2093178404 hasAuthorship W2093178404A5019166579 @default.
• W2093178404 hasAuthorship W2093178404A5021544084 @default.
• W2093178404 hasAuthorship W2093178404A5041461719 @default.
• W2093178404 hasAuthorship W2093178404A5069154294 @default.
• W2093178404 hasBestOaLocation W20931784041 @default.
• W2093178404 hasConcept C2776008901 @default.
• W2093178404 hasConcept C2776460866 @default.
• W2093178404 hasConcept C2778039029 @default.
• W2093178404 hasConcept C2778080818 @default.
• W2093178404 hasConcept C2778163477 @default.
• W2093178404 hasConcept C2778718757 @default.
• W2093178404 hasConcept C2779548794 @default.
• W2093178404 hasConcept C2780125187 @default.
• W2093178404 hasConcept C2780306465 @default.
• W2093178404 hasConcept C2780315139 @default.
• W2093178404 hasConcept C55493867 @default.
• W2093178404 hasConcept C59822182 @default.
• W2093178404 hasConcept C74600772 @default.
• W2093178404 hasConcept C86803240 @default.
• W2093178404 hasConcept C89423630 @default.
• W2093178404 hasConceptScore W2093178404C2776008901 @default.
• W2093178404 hasConceptScore W2093178404C2776460866 @default.
• W2093178404 hasConceptScore W2093178404C2778039029 @default.
• W2093178404 hasConceptScore W2093178404C2778080818 @default.
• W2093178404 hasConceptScore W2093178404C2778163477 @default.
• W2093178404 hasConceptScore W2093178404C2778718757 @default.
• W2093178404 hasConceptScore W2093178404C2779548794 @default.
• W2093178404 hasConceptScore W2093178404C2780125187 @default.
• W2093178404 hasConceptScore W2093178404C2780306465 @default.
• W2093178404 hasConceptScore W2093178404C2780315139 @default.
• W2093178404 hasConceptScore W2093178404C55493867 @default.
• W2093178404 hasConceptScore W2093178404C59822182 @default.
• W2093178404 hasConceptScore W2093178404C74600772 @default.
• W2093178404 hasConceptScore W2093178404C86803240 @default.
• W2093178404 hasConceptScore W2093178404C89423630 @default.
• W2093178404 hasIssue "3" @default.
• W2093178404 hasLocation W20931784041 @default.
• W2093178404 hasLocation W20931784042 @default.
• W2093178404 hasOpenAccess W2093178404 @default.
• W2093178404 hasPrimaryLocation W20931784041 @default.
• W2093178404 hasRelatedWork W1578638626 @default.
• W2093178404 hasRelatedWork W1591532256 @default.
• W2093178404 hasRelatedWork W1907348172 @default.

• next