Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093181542> ?p ?o ?g. }
- W2093181542 endingPage "342" @default.
- W2093181542 startingPage "333" @default.
- W2093181542 abstract "Acute muscle necrosis was induced in rats by intramuscular injection of plasmocid, a known myotoxic agent. A single injection of 5 mg/ml plasmocid produced massive fiber necrosis with extensive phagocytosis. Plasmocid administration led to a preferential decrease of alpha-actinin with preservation of other structural proteins within 3 h after injection, and large increases (2-7-fold) in the activities of acid hydrolases, cathepsins B and L, cathepsin D and alpha-galactosidase within 48 h after injection. The plasmocid-induced stimulation of alpha-actinin loss seen at 3 h, when no increases of acid hydrolases occurred, could be inhibited by a cysteine protease inhibitor, Ep-475 (E-64-c), and EGTA. On the other hand, increased lysosomal enzyme activity seemed to have a close correlation with the appearance of invading mononuclear cells, probably macrophages, and not muscle lysosomes. These observations suggest that a two step mechanism of protein degradation (nonlysosomal and lysosomal processes) possibly occurs in plasmocid-induced muscle degradation and macrophages can serve as a main endogenous reservoir of proteases in pathological states." @default.
- W2093181542 created "2016-06-24" @default.
- W2093181542 creator A5001477991 @default.
- W2093181542 creator A5003315468 @default.
- W2093181542 creator A5017883173 @default.
- W2093181542 creator A5020689785 @default.
- W2093181542 creator A5029649380 @default.
- W2093181542 date "1984-04-24" @default.
- W2093181542 modified "2023-09-26" @default.
- W2093181542 title "Two-step mechanism of myofibrillar protein degradation in acute plasmocid-induced muscle necrosis" @default.
- W2093181542 cites W126860879 @default.
- W2093181542 cites W1487336010 @default.
- W2093181542 cites W1540408159 @default.
- W2093181542 cites W1551625927 @default.
- W2093181542 cites W1595306598 @default.
- W2093181542 cites W1681535119 @default.
- W2093181542 cites W174742522 @default.
- W2093181542 cites W1775749144 @default.
- W2093181542 cites W1812339273 @default.
- W2093181542 cites W1854259382 @default.
- W2093181542 cites W1977068625 @default.
- W2093181542 cites W1985371102 @default.
- W2093181542 cites W1999115076 @default.
- W2093181542 cites W2016874808 @default.
- W2093181542 cites W2038514347 @default.
- W2093181542 cites W2040648848 @default.
- W2093181542 cites W2055073050 @default.
- W2093181542 cites W2056493955 @default.
- W2093181542 cites W2058064327 @default.
- W2093181542 cites W2059615140 @default.
- W2093181542 cites W2069164978 @default.
- W2093181542 cites W2069395571 @default.
- W2093181542 cites W2080996529 @default.
- W2093181542 cites W2087508139 @default.
- W2093181542 cites W2100837269 @default.
- W2093181542 cites W2105066414 @default.
- W2093181542 cites W2126571971 @default.
- W2093181542 cites W2126656466 @default.
- W2093181542 cites W2136438527 @default.
- W2093181542 cites W2146720027 @default.
- W2093181542 cites W2165886387 @default.
- W2093181542 cites W2222227825 @default.
- W2093181542 cites W2305522824 @default.
- W2093181542 cites W2470400479 @default.
- W2093181542 cites W269881857 @default.
- W2093181542 cites W626928110 @default.
- W2093181542 cites W1943738672 @default.
- W2093181542 doi "https://doi.org/10.1016/0304-4165(84)90107-7" @default.
- W2093181542 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6424726" @default.
- W2093181542 hasPublicationYear "1984" @default.
- W2093181542 type Work @default.
- W2093181542 sameAs 2093181542 @default.
- W2093181542 citedByCount "13" @default.
- W2093181542 crossrefType "journal-article" @default.
- W2093181542 hasAuthorship W2093181542A5001477991 @default.
- W2093181542 hasAuthorship W2093181542A5003315468 @default.
- W2093181542 hasAuthorship W2093181542A5017883173 @default.
- W2093181542 hasAuthorship W2093181542A5020689785 @default.
- W2093181542 hasAuthorship W2093181542A5029649380 @default.
- W2093181542 hasConcept C126322002 @default.
- W2093181542 hasConcept C134018914 @default.
- W2093181542 hasConcept C160448771 @default.
- W2093181542 hasConcept C167844969 @default.
- W2093181542 hasConcept C173633252 @default.
- W2093181542 hasConcept C181199279 @default.
- W2093181542 hasConcept C182220744 @default.
- W2093181542 hasConcept C185592680 @default.
- W2093181542 hasConcept C21547065 @default.
- W2093181542 hasConcept C24998067 @default.
- W2093181542 hasConcept C2776714187 @default.
- W2093181542 hasConcept C2777283782 @default.
- W2093181542 hasConcept C2780216420 @default.
- W2093181542 hasConcept C28021979 @default.
- W2093181542 hasConcept C2992195973 @default.
- W2093181542 hasConcept C503630168 @default.
- W2093181542 hasConcept C55493867 @default.
- W2093181542 hasConcept C71924100 @default.
- W2093181542 hasConcept C7301908 @default.
- W2093181542 hasConcept C86803240 @default.
- W2093181542 hasConcept C95444343 @default.
- W2093181542 hasConceptScore W2093181542C126322002 @default.
- W2093181542 hasConceptScore W2093181542C134018914 @default.
- W2093181542 hasConceptScore W2093181542C160448771 @default.
- W2093181542 hasConceptScore W2093181542C167844969 @default.
- W2093181542 hasConceptScore W2093181542C173633252 @default.
- W2093181542 hasConceptScore W2093181542C181199279 @default.
- W2093181542 hasConceptScore W2093181542C182220744 @default.
- W2093181542 hasConceptScore W2093181542C185592680 @default.
- W2093181542 hasConceptScore W2093181542C21547065 @default.
- W2093181542 hasConceptScore W2093181542C24998067 @default.
- W2093181542 hasConceptScore W2093181542C2776714187 @default.
- W2093181542 hasConceptScore W2093181542C2777283782 @default.
- W2093181542 hasConceptScore W2093181542C2780216420 @default.
- W2093181542 hasConceptScore W2093181542C28021979 @default.
- W2093181542 hasConceptScore W2093181542C2992195973 @default.
- W2093181542 hasConceptScore W2093181542C503630168 @default.
- W2093181542 hasConceptScore W2093181542C55493867 @default.
- W2093181542 hasConceptScore W2093181542C71924100 @default.