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• W2093182664 abstract "Five non-covalent vaccines of outer membrane proteins (OMPs) complexed to capsular polysaccharide were prepared from Neisseria meningitidis serogroup B strains. Each vaccine contained distinct serotype (class 23) and subtype (class 1) OMPs. The cross-reactivity of the T-cell response to the meningococcal vaccine-associated proteins was examined in an in vitro T-cell proliferative assay, following antigenic priming of mice with one of these vaccines (MB6 : P1.6) or with its purified class 1 (subtype P1.6) and class 2 (serotype 6) proteins. Cross-reactive T-cell epitopes were found in all five vaccine preparations on both the class 1 and class 23 OMPs. Priming of mice with the subtype P1.6 N-terminal peptide led to a significant but small increase in T-cell proliferation with the MB6 : P1.6 vaccine." @default.
• W2093182664 created "2016-06-24" @default.
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• W2093182664 date "1992-01-01" @default.
• W2093182664 modified "2023-09-26" @default.
• W2093182664 title "Murine cross-reactive T-cell epitopes of Neisseria meningitidis outer membrane proteins" @default.
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• W2093182664 doi "https://doi.org/10.1016/0264-410x(92)90005-5" @default.
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