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- W2093183763 abstract "In vertebrate visual and olfactory systems, a cyclic nucleotide–gated channel couples receptor activation to electrical activity of the sensory neurons. The Caenorhabditis elegans tax-2 gene is required for some forms of olfaction, for chemosensation of salts, and for thermosensation. We show here that tax-2 encodes a predicted subunit of a cyclic nucleotide–gated channel that is expressed in olfactory, gustatory, and thermosensory neurons, implicating this channel in multiple sensory modalities. Some sensory neurons display axon outgrowth defects in tax-2 mutants. Thus, the channel has an unexpected role in sensory neuron development in addition to its role in sensation. Consistent with this proposed dual function, a Tax-2::GFP fusion protein is present both in sensory cilia and in sensory axons." @default.
- W2093183763 created "2016-06-24" @default.
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- W2093183763 date "2009-01-01" @default.
- W2093183763 modified "2023-09-28" @default.
- W2093183763 title "Mapping suppressor mutation of the eat-16 mutant defective in G protein-coupled thermosensation" @default.
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- W2093183763 doi "https://doi.org/10.1016/j.neures.2009.09.516" @default.
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