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- W2093184583 abstract "Life-threatening fungal infections have increased in recent years while treatment options remain limited. The development of vaccines against fungal pathogens represents a key advance sorely needed to combat the increasing fungal disease threat. Dendritic cells (DC) are uniquely able to shape antifungal immunity by initiating and modulating naive T cell responses. Targeting DC may allow for the generation of potent vaccines against fungal pathogens. In the context of antifungal vaccine design, we describe the characteristics of the varied DC subsets, how DC recognize fungi, their function in immunity against fungal pathogens, and how DC can be targeted in order to create new antifungal vaccines. Ongoing studies continue to highlight the critical role of DC in antifungal immunity and will help guide DC-based vaccine strategies. Life-threatening fungal infections have increased in recent years while treatment options remain limited. The development of vaccines against fungal pathogens represents a key advance sorely needed to combat the increasing fungal disease threat. Dendritic cells (DC) are uniquely able to shape antifungal immunity by initiating and modulating naive T cell responses. Targeting DC may allow for the generation of potent vaccines against fungal pathogens. In the context of antifungal vaccine design, we describe the characteristics of the varied DC subsets, how DC recognize fungi, their function in immunity against fungal pathogens, and how DC can be targeted in order to create new antifungal vaccines. Ongoing studies continue to highlight the critical role of DC in antifungal immunity and will help guide DC-based vaccine strategies." @default.
- W2093184583 created "2016-06-24" @default.
- W2093184583 creator A5010768212 @default.
- W2093184583 creator A5047222507 @default.
- W2093184583 date "2012-05-01" @default.
- W2093184583 modified "2023-10-07" @default.
- W2093184583 title "Dendritic Cells in Antifungal Immunity and Vaccine Design" @default.
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- W2093184583 doi "https://doi.org/10.1016/j.chom.2012.04.005" @default.
- W2093184583 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3401965" @default.
- W2093184583 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22607797" @default.
- W2093184583 hasPublicationYear "2012" @default.
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