FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093186906> ?p ?o ?g. }

• W2093186906 endingPage "203" @default.
• W2093186906 startingPage "195" @default.
• W2093186906 abstract "Aim: The insulin sensitizer rosiglitazone (RTZ) acts by activating peroxisome proliferator and activated receptor γ (PPAR γ), an effect accompanied in vivo in humans by an increase in fat storage. We hypothesized that this effect concerns PPARγ1 and PPARγ2 differently and is dependant on the origin of the adipose cells (subcutaneous or visceral). To this aim, the effect of RTZ, the PPARγ antagonist GW9662 and lentiviral vectors expressing interfering RNA were evaluated on human pre-adipocyte models. Methods: Two models were investigated: the human pre-adipose cell line Chub-S7 and primary pre-adipocytes derived from subcutaneous and visceral biopsies of adipose tissue (AT) obtained from obese patients. Cells were used to perform oil-red O staining, gene expression measurements and lentiviral infections. Results: In both models, RTZ was found to stimulate the differentiation of pre-adipocytes into mature cells. This was accompanied by significant increases in both the PPARγ1 and PPARγ2 gene expression, with a relatively stronger stimulation of PPARγ2. In contrast, RTZ failed to stimulate differentiation processes when cells were incubated in the presence of GW9662. This effect was similar to the effect observed using interfering RNA against PPARγ2. It was accompanied by an abrogation of the RTZ-induced PPARγ2 gene expression, whereas the level of PPARγ1 was not affected. Conclusions: Both the GW9662 treatment and interfering RNA against PPARγ2 are able to abrogate RTZ-induced differentiation without a significant change of PPARγ1 gene expression. These results are consistent with previous results obtained in animal models and suggest that in humans PPARγ2 may also be the key isoform involved in fat storage." @default.
• W2093186906 created "2016-06-24" @default.
• W2093186906 creator A5005035664 @default.
• W2093186906 creator A5010435969 @default.
• W2093186906 creator A5016232458 @default.
• W2093186906 creator A5020979512 @default.
• W2093186906 creator A5029474396 @default.
• W2093186906 creator A5034637211 @default.
• W2093186906 creator A5057342334 @default.
• W2093186906 creator A5063388241 @default.
• W2093186906 creator A5079943359 @default.
• W2093186906 date "2010-03-01" @default.
• W2093186906 modified "2023-10-04" @default.
• W2093186906 title "Selective effects of PPARγ agonists and antagonists on human pre-adipocyte differentiation" @default.
• W2093186906 cites W1556459089 @default.
• W2093186906 cites W1971311471 @default.
• W2093186906 cites W1979804924 @default.
• W2093186906 cites W1997304834 @default.
• W2093186906 cites W1999865642 @default.
• W2093186906 cites W2000821877 @default.
• W2093186906 cites W2005267351 @default.
• W2093186906 cites W2014259643 @default.
• W2093186906 cites W2015616869 @default.
• W2093186906 cites W2023229796 @default.
• W2093186906 cites W2026741374 @default.
• W2093186906 cites W2036586168 @default.
• W2093186906 cites W2061988825 @default.
• W2093186906 cites W2065738055 @default.
• W2093186906 cites W2067958701 @default.
• W2093186906 cites W2068933722 @default.
• W2093186906 cites W2074273934 @default.
• W2093186906 cites W2078893386 @default.
• W2093186906 cites W2089235913 @default.
• W2093186906 cites W2097899015 @default.
• W2093186906 cites W2110919070 @default.
• W2093186906 cites W2117456369 @default.
• W2093186906 cites W2120875133 @default.
• W2093186906 cites W2122709204 @default.
• W2093186906 cites W2128249506 @default.
• W2093186906 cites W2132484596 @default.
• W2093186906 cites W2137350506 @default.
• W2093186906 cites W2138825018 @default.
• W2093186906 cites W2145329718 @default.
• W2093186906 cites W2151980290 @default.
• W2093186906 cites W2156538361 @default.
• W2093186906 cites W2159230151 @default.
• W2093186906 cites W2159621813 @default.
• W2093186906 cites W2164015929 @default.
• W2093186906 cites W2168681940 @default.
• W2093186906 cites W2216740935 @default.
• W2093186906 doi "https://doi.org/10.1111/j.1463-1326.2009.01149.x" @default.
• W2093186906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19895635" @default.
• W2093186906 hasPublicationYear "2010" @default.
• W2093186906 type Work @default.
• W2093186906 sameAs 2093186906 @default.
• W2093186906 citedByCount "11" @default.
• W2093186906 countsByYear W20931869062012 @default.
• W2093186906 countsByYear W20931869062013 @default.
• W2093186906 countsByYear W20931869062015 @default.
• W2093186906 countsByYear W20931869062018 @default.
• W2093186906 crossrefType "journal-article" @default.
• W2093186906 hasAuthorship W2093186906A5005035664 @default.
• W2093186906 hasAuthorship W2093186906A5010435969 @default.
• W2093186906 hasAuthorship W2093186906A5016232458 @default.
• W2093186906 hasAuthorship W2093186906A5020979512 @default.
• W2093186906 hasAuthorship W2093186906A5029474396 @default.
• W2093186906 hasAuthorship W2093186906A5034637211 @default.
• W2093186906 hasAuthorship W2093186906A5057342334 @default.
• W2093186906 hasAuthorship W2093186906A5063388241 @default.
• W2093186906 hasAuthorship W2093186906A5079943359 @default.
• W2093186906 hasConcept C104317684 @default.
• W2093186906 hasConcept C122927707 @default.
• W2093186906 hasConcept C126322002 @default.
• W2093186906 hasConcept C134018914 @default.
• W2093186906 hasConcept C150194340 @default.
• W2093186906 hasConcept C170493617 @default.
• W2093186906 hasConcept C171089720 @default.
• W2093186906 hasConcept C185592680 @default.
• W2093186906 hasConcept C187345961 @default.
• W2093186906 hasConcept C202751555 @default.
• W2093186906 hasConcept C22615655 @default.
• W2093186906 hasConcept C24998067 @default.
• W2093186906 hasConcept C2776175234 @default.
• W2093186906 hasConcept C2776885963 @default.
• W2093186906 hasConcept C2779306644 @default.
• W2093186906 hasConcept C2780152017 @default.
• W2093186906 hasConcept C2780806160 @default.
• W2093186906 hasConcept C55493867 @default.
• W2093186906 hasConcept C67705224 @default.
• W2093186906 hasConcept C71924100 @default.
• W2093186906 hasConcept C86803240 @default.
• W2093186906 hasConcept C95444343 @default.
• W2093186906 hasConceptScore W2093186906C104317684 @default.
• W2093186906 hasConceptScore W2093186906C122927707 @default.
• W2093186906 hasConceptScore W2093186906C126322002 @default.
• W2093186906 hasConceptScore W2093186906C134018914 @default.
• W2093186906 hasConceptScore W2093186906C150194340 @default.
• W2093186906 hasConceptScore W2093186906C170493617 @default.

• next