FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093202316> ?p ?o ?g. }

• W2093202316 endingPage "951" @default.
• W2093202316 startingPage "944" @default.
• W2093202316 abstract "The enzyme As(III) S-adenosylmethionine methyltransferase (EC 2.1.1.137) (ArsM or AS3MT) is found in members of every kingdom, from bacteria to humans. In these enzymes, there are three conserved cysteine residues at positions 72, 174, and 224 in the CmArsM orthologue from the thermophilic eukaryotic alga Cyanidioschyzon sp. 5508. Substitution of any of the three led to loss of As(III) methylation. In contrast, a C72A mutant still methylated trivalent methylarsenite [MAs(III)]. Protein fluorescence of a single-tryptophan mutant reported binding of As(III) or MAs(III). As(GS)3 and MAs(GS)2 bound significantly faster than As(III), suggesting that the glutathionylated arsenicals are preferred substrates for the enzyme. Protein fluorescence also reported binding of Sb(III), and the purified enzyme methylated and volatilized Sb(III). The results suggest that all three cysteine residues are necessary for the first step in the reaction, As(III) methylation, but that only Cys174 and Cys224 are required for the second step, methylation of MAs(III) to dimethylarsenite [DMAs(III)]. The rate-limiting step was identified as the conversion of DMAs(III) to trimethylarsine, and DMAs(III) accumulates as the principal product." @default.
• W2093202316 created "2016-06-24" @default.
• W2093202316 creator A5000349109 @default.
• W2093202316 creator A5039895393 @default.
• W2093202316 creator A5058396685 @default.
• W2093202316 date "2012-01-26" @default.
• W2093202316 modified "2023-10-03" @default.
• W2093202316 title "Identification of Catalytic Residues in the As(III) <i>S</i>-Adenosylmethionine Methyltransferase" @default.
• W2093202316 cites W1966361420 @default.
• W2093202316 cites W1967693726 @default.
• W2093202316 cites W1968039127 @default.
• W2093202316 cites W1975629656 @default.
• W2093202316 cites W1979671267 @default.
• W2093202316 cites W1986648586 @default.
• W2093202316 cites W1995725157 @default.
• W2093202316 cites W1997565776 @default.
• W2093202316 cites W2005986251 @default.
• W2093202316 cites W2013249689 @default.
• W2093202316 cites W2022409886 @default.
• W2093202316 cites W2022550921 @default.
• W2093202316 cites W2032475003 @default.
• W2093202316 cites W2032780020 @default.
• W2093202316 cites W2036471969 @default.
• W2093202316 cites W2047975812 @default.
• W2093202316 cites W2079639390 @default.
• W2093202316 cites W2127967852 @default.
• W2093202316 cites W2142818640 @default.
• W2093202316 cites W2156437329 @default.
• W2093202316 cites W2410307312 @default.
• W2093202316 doi "https://doi.org/10.1021/bi201500c" @default.
• W2093202316 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3431559" @default.
• W2093202316 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22257120" @default.
• W2093202316 hasPublicationYear "2012" @default.
• W2093202316 type Work @default.
• W2093202316 sameAs 2093202316 @default.
• W2093202316 citedByCount "83" @default.
• W2093202316 countsByYear W20932023162012 @default.
• W2093202316 countsByYear W20932023162013 @default.
• W2093202316 countsByYear W20932023162014 @default.
• W2093202316 countsByYear W20932023162015 @default.
• W2093202316 countsByYear W20932023162016 @default.
• W2093202316 countsByYear W20932023162017 @default.
• W2093202316 countsByYear W20932023162018 @default.
• W2093202316 countsByYear W20932023162019 @default.
• W2093202316 countsByYear W20932023162020 @default.
• W2093202316 countsByYear W20932023162021 @default.
• W2093202316 countsByYear W20932023162022 @default.
• W2093202316 countsByYear W20932023162023 @default.
• W2093202316 crossrefType "journal-article" @default.
• W2093202316 hasAuthorship W2093202316A5000349109 @default.
• W2093202316 hasAuthorship W2093202316A5039895393 @default.
• W2093202316 hasAuthorship W2093202316A5058396685 @default.
• W2093202316 hasBestOaLocation W20932023162 @default.
• W2093202316 hasConcept C104317684 @default.
• W2093202316 hasConcept C143065580 @default.
• W2093202316 hasConcept C181199279 @default.
• W2093202316 hasConcept C185592680 @default.
• W2093202316 hasConcept C2776706248 @default.
• W2093202316 hasConcept C2779201268 @default.
• W2093202316 hasConcept C2780912031 @default.
• W2093202316 hasConcept C33288867 @default.
• W2093202316 hasConcept C515207424 @default.
• W2093202316 hasConcept C552990157 @default.
• W2093202316 hasConcept C55493867 @default.
• W2093202316 hasConcept C71240020 @default.
• W2093202316 hasConcept C91965660 @default.
• W2093202316 hasConceptScore W2093202316C104317684 @default.
• W2093202316 hasConceptScore W2093202316C143065580 @default.
• W2093202316 hasConceptScore W2093202316C181199279 @default.
• W2093202316 hasConceptScore W2093202316C185592680 @default.
• W2093202316 hasConceptScore W2093202316C2776706248 @default.
• W2093202316 hasConceptScore W2093202316C2779201268 @default.
• W2093202316 hasConceptScore W2093202316C2780912031 @default.
• W2093202316 hasConceptScore W2093202316C33288867 @default.
• W2093202316 hasConceptScore W2093202316C515207424 @default.
• W2093202316 hasConceptScore W2093202316C552990157 @default.
• W2093202316 hasConceptScore W2093202316C55493867 @default.
• W2093202316 hasConceptScore W2093202316C71240020 @default.
• W2093202316 hasConceptScore W2093202316C91965660 @default.
• W2093202316 hasIssue "5" @default.
• W2093202316 hasLocation W20932023161 @default.
• W2093202316 hasLocation W20932023162 @default.
• W2093202316 hasLocation W20932023163 @default.
• W2093202316 hasLocation W20932023164 @default.
• W2093202316 hasOpenAccess W2093202316 @default.
• W2093202316 hasPrimaryLocation W20932023161 @default.
• W2093202316 hasRelatedWork W2026424036 @default.
• W2093202316 hasRelatedWork W2093202316 @default.
• W2093202316 hasRelatedWork W2141508513 @default.
• W2093202316 hasRelatedWork W2162200231 @default.
• W2093202316 hasRelatedWork W2326822531 @default.
• W2093202316 hasRelatedWork W2343184440 @default.
• W2093202316 hasRelatedWork W2343585246 @default.
• W2093202316 hasRelatedWork W2492725499 @default.
• W2093202316 hasRelatedWork W2777809930 @default.
• W2093202316 hasRelatedWork W4211021704 @default.
• W2093202316 hasVolume "51" @default.
• W2093202316 isParatext "false" @default.

• next