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- W2093202743 abstract "Gastroenteropancreatic neuroendocrine tumours (GEP NETs) originate from the neuroendocrine cells through the gastrointestinal tract and endocrine pancreas. The embryologic development of the pancreas is a complex process that begins with the stem cell that come from the endodermus. These cells go through two phases: in the first transition the stem cell differentiates in exocrine and endocrine cells. This process is regulated by transcription factors such as Pdx1 (insulin promoter factor 1), Hlxb6 and SOX9. In the second transition the neuroendocrine cell differentiates in the 5 cell types (alpha, beta, delta, PP y epsilon.). This process is regulated through the balance between factors favoring differentiation (mainly neurogenin 3) and inhibitor factors which depend on Notch signals. The existence of a third transition in postnatal pancreas is hypothesized. The stem cell from pancreatic ducts would become adult beta cells, through autoduplication and neogenesis. In the small gut of the adult the stem cell are placed in the intestinal crypts and develop to villi in secretor lines (enterocytes, globet and Paneths cells) or neuroendocrine cells from which at least 10 cell types depend. This process is regulated by transcription factors: Math1, neurogenina 3 and NeuroD." @default.
- W2093202743 created "2016-06-24" @default.
- W2093202743 creator A5046175572 @default.
- W2093202743 date "2009-04-01" @default.
- W2093202743 modified "2023-10-18" @default.
- W2093202743 title "Sistema neuroendocrino del páncreas y tracto gastrointestinal: origen y desarrollo" @default.
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- W2093202743 doi "https://doi.org/10.1016/s1575-0922(09)70858-7" @default.
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