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- W2093203488 abstract "A 49-year-old, well nourished, well developed, African-American man presented by referral to the oral and maxillofacial surgeon's office for the evaluation and management of a 2 × 2-cm deeply pigmented lesion with an erythematous border located in his left soft palatal mucosa. The lesion was superficial but contained a small area of central ulceration. Review of his past medial history was significant for peripheral vascular disease and diabetes. Review of his social history revealed a 30-packs/year history of smoking and daily consumption of alcoholic beverages. An incisional biopsy showed carcinoma in situ with extensive dendritic melanocytic colonization. The dysplastic changes also focally involved salivary gland ductal epithelium. Immunohistochemical staining with anti-HMB45 and anti-S-100 protein antibodies clearly delineated the dendritic melanocytes and melanocytic processes. Staining with broad spectrum cytokeratin was strong and diffuse. An outside expert was consulted and agreed with our interpretation. The lesion was excised with clear margins and the resection specimen showed findings identical to the biopsy. Melanocytic colonization is a well recognized occurrence in various primary and metastatic tumors including oral and cutaneous squamous cell carcinoma, but the incidence remains low and the significance of such finding remains to be determined. Various theories have been proposed to explain the proliferation and colonization of melanocytes, including the liberation of cytokines, growth factors, or other unknown factors by cancer cells. It has been suggested also that in ulcerated lesions, the presence of the melanocytes may represent cells that migrated into the existing lesion. In this case report, we review the literature and theories of etiology. The keratinocyte-melanocyte relationship is also investigated in this interesting entity." @default.
- W2093203488 created "2016-06-24" @default.
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- W2093203488 date "2004-08-01" @default.
- W2093203488 modified "2023-10-18" @default.
- W2093203488 title "Oral carcinoma in situ with extensive dendritic melanocytic colonization" @default.
- W2093203488 doi "https://doi.org/10.1016/j.tripleo.2004.06.061" @default.
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