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- W2093211068 abstract "Cells of human RSA cell line, with high senstivity to UV killing and low capacity for DNA repair, when pretreated with 1–100 units/ml of human interferon (HuIFN) preparations for more than 12 h before irradiation, acquired an enhancement of UV-induced DNA-repair relications synthesis in association with recovery from inhibition of total cellular DNA synthesis and UV survival. Prompt and transient induction of plasminogen activator activities was also found within 5 min after UV irradiation in the cells pretreated with HuIFN but not in the cells non-pretreated with HuIFN. The enhancement and induction effects of HuIFN were observed, irrespective of the kind of HuIFN preparation used (α, β or γ, and natural or recombinant) and in other UV-sensitive fibroblast cells which were derived from Cockayne syndrome and xeroderma pigmentosum fibroblasts (XP1KY). However, all of the enhancement of DNA-repair synthesis and the induction of plasminogen activator activities by HuIFN was suppressed by treatment with cycloheximide immediately after UV irradiation." @default.
- W2093211068 created "2016-06-24" @default.
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- W2093211068 date "1988-03-01" @default.
- W2093211068 modified "2023-09-30" @default.
- W2093211068 title "Effects of human interferon on cellular response to UV in UV-sensitive human cell strains" @default.
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- W2093211068 doi "https://doi.org/10.1016/0027-5107(88)90056-5" @default.
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