Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093222395> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W2093222395 endingPage "337" @default.
- W2093222395 startingPage "337" @default.
- W2093222395 abstract "The effects of the phenylglycine derivatives, α-methyl-4-carboxyphenylglycine (MCPG), 4-carboxyphenylglycine (4CPG), 4-carboxy-3-hydroxyphenylglycine (4C3HPG), 3-hydroxyphenylglycine (3HPG) and 3,5-dihydrohyphenylglycine (DHPG) were tested on LLC-PK1 cells transiently expressing the rat mGluR1a or mGluR5a receptors. As previously reported by others, (S)-3HPG and (RS)-DHPG were found to be partial agonists at mGluR1a, whereas (+)-MCPG, (S)-4CPG and (S)-4C3HPG competitively antagonized the effect of Glu. Surprisingly, the 4-carboxy derivatives of phenylglycine antagonized the effect of 1S,3R-ACPD on mGluR1a with lower KB values. On mGluR5a, (S)-3HPG and (RS)-DHPG are also partial agonists. However, in contrast to their effects on mGluR1a, (S)-4CPG did not inhibit the effect of Glu or 1S,3R-ACPD, and (S)-4C3HPG acted as an agonist at high concentration. Whereas no significant antagonism of the Glu effect on mGluR5a was observed with 1 mM (+)-MCPG, this compound was found to potently and competitively antagonize the effect of 1S,3R-ACPD. Finally, the effect of 4CPG was also examined on cultured cortical and cerebellar neurons that express mGluR5 and mGluR1 mRNA, respectively. 4CPG inhibited 1S,3R-ACPD-stimulated IP production in cerebellar neurons only. These results (1) demonstrate that phenylglycine derivatives can be used to discriminate between effects mediated by mGluR1 and mGluR5 and (2) suggest that the apparent potency of phenylglycine antagonists depends on the agonist used to activate these receptors." @default.
- W2093222395 created "2016-06-24" @default.
- W2093222395 creator A5024551605 @default.
- W2093222395 creator A5050180649 @default.
- W2093222395 date "1995-01-01" @default.
- W2093222395 modified "2023-09-26" @default.
- W2093222395 title "Effects of metabotropic glutamate receptors antagonists on the synaptic transmission in the rat hippocampal slices" @default.
- W2093222395 doi "https://doi.org/10.1016/1043-6618(95)87607-3" @default.
- W2093222395 hasPublicationYear "1995" @default.
- W2093222395 type Work @default.
- W2093222395 sameAs 2093222395 @default.
- W2093222395 citedByCount "0" @default.
- W2093222395 crossrefType "journal-article" @default.
- W2093222395 hasAuthorship W2093222395A5024551605 @default.
- W2093222395 hasAuthorship W2093222395A5050180649 @default.
- W2093222395 hasConcept C170493617 @default.
- W2093222395 hasConcept C185592680 @default.
- W2093222395 hasConcept C200170125 @default.
- W2093222395 hasConcept C207951395 @default.
- W2093222395 hasConcept C26702167 @default.
- W2093222395 hasConcept C2777603759 @default.
- W2093222395 hasConcept C2778938600 @default.
- W2093222395 hasConcept C41653306 @default.
- W2093222395 hasConcept C49051014 @default.
- W2093222395 hasConcept C55493867 @default.
- W2093222395 hasConcept C61174792 @default.
- W2093222395 hasConcept C86803240 @default.
- W2093222395 hasConcept C98274493 @default.
- W2093222395 hasConceptScore W2093222395C170493617 @default.
- W2093222395 hasConceptScore W2093222395C185592680 @default.
- W2093222395 hasConceptScore W2093222395C200170125 @default.
- W2093222395 hasConceptScore W2093222395C207951395 @default.
- W2093222395 hasConceptScore W2093222395C26702167 @default.
- W2093222395 hasConceptScore W2093222395C2777603759 @default.
- W2093222395 hasConceptScore W2093222395C2778938600 @default.
- W2093222395 hasConceptScore W2093222395C41653306 @default.
- W2093222395 hasConceptScore W2093222395C49051014 @default.
- W2093222395 hasConceptScore W2093222395C55493867 @default.
- W2093222395 hasConceptScore W2093222395C61174792 @default.
- W2093222395 hasConceptScore W2093222395C86803240 @default.
- W2093222395 hasConceptScore W2093222395C98274493 @default.
- W2093222395 hasLocation W20932223951 @default.
- W2093222395 hasOpenAccess W2093222395 @default.
- W2093222395 hasPrimaryLocation W20932223951 @default.
- W2093222395 hasRelatedWork W1974294719 @default.
- W2093222395 hasRelatedWork W1987338717 @default.
- W2093222395 hasRelatedWork W1996737425 @default.
- W2093222395 hasRelatedWork W2001165441 @default.
- W2093222395 hasRelatedWork W2008589416 @default.
- W2093222395 hasRelatedWork W2054857167 @default.
- W2093222395 hasRelatedWork W2122559235 @default.
- W2093222395 hasRelatedWork W2357777527 @default.
- W2093222395 hasRelatedWork W2398534618 @default.
- W2093222395 hasRelatedWork W3210168476 @default.
- W2093222395 hasVolume "31" @default.
- W2093222395 isParatext "false" @default.
- W2093222395 isRetracted "false" @default.
- W2093222395 magId "2093222395" @default.
- W2093222395 workType "article" @default.