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- W2093224063 endingPage "7080" @default.
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- W2093224063 abstract "Bacteriophage T4 late promoters, which consist of a simple 8-base pair TATA box, are recognized by the gene 55 protein (gp55), a small, highly diverged member of the ς family proteins that replaces ς70 during the final phase of the T4 multiplication cycle. A 16-amino acid segment of gp55 that is proposed to be homologous to the ς70 region 2.2 has been subjected to alanine scanning and other mutagenesis. The corresponding proteins have been examined in vitro for binding toEscherichia coli RNA polymerase core enzyme and for the ability to generate accurately initiating basal as well as sliding clamp-activated T4 late transcription. Mutations in the amino acid 68–83 segment of gp55 generate a wide range of effects on these functions. The changes are interpreted in terms of the multiple steps of involvement of gp55, like other ς proteins, in transcription. Effects of mutations on RNA polymerase core binding are consistent with the previously proposed homology of amino acids 68–82 of gp55 with ς70 region 2.2 and the recently determined structures of the Thermus thermophilus and Thermus aquaticusς70-RNA polymerase holoenzymes." @default.
- W2093224063 created "2016-06-24" @default.
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- W2093224063 date "2003-02-01" @default.
- W2093224063 modified "2023-09-29" @default.
- W2093224063 title "Mutational and Functional Analysis of a Segment of the Sigma Family Bacteriophage T4 Late Promoter Recognition Protein gp55" @default.
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- W2093224063 doi "https://doi.org/10.1074/jbc.m211447200" @default.
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