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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093235637> ?p ?o ?g. }

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• W2093235637 abstract "The identification and development of a novel series of small molecule Enhancer of Zeste Homologue 2 (EZH2) inhibitors is described. A concise and modular synthesis enabled the rapid development of structure–activity relationships, which led to the identification of 44 as a potent, SAM-competitive inhibitor of EZH2 that dose-dependently decreased global H3K27me3 in KARPAS-422 lymphoma cells." @default.
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• W2093235637 date "2014-01-23" @default.
• W2093235637 modified "2023-10-16" @default.
• W2093235637 title "Discovery and Optimization of Tetramethylpiperidinyl Benzamides as Inhibitors of EZH2" @default.
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• W2093235637 doi "https://doi.org/10.1021/ml400494b" @default.
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