Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093236229> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2093236229 endingPage "5" @default.
- W2093236229 startingPage "1" @default.
- W2093236229 abstract "Simvastatin is cholesterol lowering agent and also a modulator of cytokine in the nervous system. The functional significance and neuroprotectiove mechanism of simvastatins in ischemic brain injury is controversial. The purpose of study is to evaluate the effect of simvastatin on ischemic brain injury and to investigate the perfusion capability of brain microvessels in the ischemic injury. This study included two series of experiments. In the first series, we studied if simvastatin is neuroprotective in an embolic model of stroke. The treatments began 2 weeks before middle cerebral artery (MCA) occlusion. Infarct volume was measured at 48 h post stroke. Neurological deficits were assessed at 2 h, 24 h and 48 h post stroke. Results showed that infarct volume in rats which received saline and simvastatin was 32.5 ± 9.3% (mean ± SD) and 18.7 ± 6.5%, respectively. The infarct volume in the simvastatin group was significantly smaller than in the controls (P < 0.002). Treatment with simvastatin also improved neurological deficits and reduced brain edema significantly (P < 0.05). In the second series, we studied if simvastatin can improve microvascular reperfusions after ischemia. Perfusion deficits were detected at 8 h post stroke using Evens blue dye. Neurological deficits were assessed at 2 h and 8 h post stroke. Results showed that perfusion deficit in saline and simvastatin-treated groups were 58.7 ± 8.7% and 23.4 ± 7.5%, respectively. The perfusion deficit in simvastatin-treated group was decreased 61% (P < 0.01). These studies thus suggest that simvastatin is a protective agent in ischemic brain injury and this protective effect may be partially due to its action in the improvement of microvascular reperfusion." @default.
- W2093236229 created "2016-06-24" @default.
- W2093236229 creator A5025618294 @default.
- W2093236229 creator A5050507154 @default.
- W2093236229 creator A5059240200 @default.
- W2093236229 date "2005-04-01" @default.
- W2093236229 modified "2023-10-03" @default.
- W2093236229 title "Simvastatin reduced ischemic brain injury and perfusion deficits in an embolic model of stroke" @default.
- W2093236229 cites W2017885661 @default.
- W2093236229 cites W2055113811 @default.
- W2093236229 cites W2057799660 @default.
- W2093236229 cites W2058902596 @default.
- W2093236229 cites W2061958421 @default.
- W2093236229 cites W2063738580 @default.
- W2093236229 cites W2069600859 @default.
- W2093236229 cites W2070013537 @default.
- W2093236229 cites W2070547475 @default.
- W2093236229 cites W2071976811 @default.
- W2093236229 cites W2075606347 @default.
- W2093236229 cites W2086374030 @default.
- W2093236229 cites W2087664582 @default.
- W2093236229 cites W2094894558 @default.
- W2093236229 cites W2101515403 @default.
- W2093236229 cites W2103946141 @default.
- W2093236229 cites W2110171695 @default.
- W2093236229 cites W2114709779 @default.
- W2093236229 cites W2125683177 @default.
- W2093236229 cites W2126305815 @default.
- W2093236229 cites W2138684097 @default.
- W2093236229 cites W2317745163 @default.
- W2093236229 cites W2887225365 @default.
- W2093236229 cites W4385778326 @default.
- W2093236229 doi "https://doi.org/10.1016/j.brainres.2005.01.105" @default.
- W2093236229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15823246" @default.
- W2093236229 hasPublicationYear "2005" @default.
- W2093236229 type Work @default.
- W2093236229 sameAs 2093236229 @default.
- W2093236229 citedByCount "44" @default.
- W2093236229 countsByYear W20932362292012 @default.
- W2093236229 countsByYear W20932362292013 @default.
- W2093236229 countsByYear W20932362292015 @default.
- W2093236229 countsByYear W20932362292016 @default.
- W2093236229 countsByYear W20932362292017 @default.
- W2093236229 countsByYear W20932362292018 @default.
- W2093236229 countsByYear W20932362292020 @default.
- W2093236229 crossrefType "journal-article" @default.
- W2093236229 hasAuthorship W2093236229A5025618294 @default.
- W2093236229 hasAuthorship W2093236229A5050507154 @default.
- W2093236229 hasAuthorship W2093236229A5059240200 @default.
- W2093236229 hasConcept C126322002 @default.
- W2093236229 hasConcept C127413603 @default.
- W2093236229 hasConcept C146957229 @default.
- W2093236229 hasConcept C164705383 @default.
- W2093236229 hasConcept C25498285 @default.
- W2093236229 hasConcept C2776329913 @default.
- W2093236229 hasConcept C2777397205 @default.
- W2093236229 hasConcept C2778820722 @default.
- W2093236229 hasConcept C2780645631 @default.
- W2093236229 hasConcept C42219234 @default.
- W2093236229 hasConcept C541997718 @default.
- W2093236229 hasConcept C71924100 @default.
- W2093236229 hasConcept C78519656 @default.
- W2093236229 hasConceptScore W2093236229C126322002 @default.
- W2093236229 hasConceptScore W2093236229C127413603 @default.
- W2093236229 hasConceptScore W2093236229C146957229 @default.
- W2093236229 hasConceptScore W2093236229C164705383 @default.
- W2093236229 hasConceptScore W2093236229C25498285 @default.
- W2093236229 hasConceptScore W2093236229C2776329913 @default.
- W2093236229 hasConceptScore W2093236229C2777397205 @default.
- W2093236229 hasConceptScore W2093236229C2778820722 @default.
- W2093236229 hasConceptScore W2093236229C2780645631 @default.
- W2093236229 hasConceptScore W2093236229C42219234 @default.
- W2093236229 hasConceptScore W2093236229C541997718 @default.
- W2093236229 hasConceptScore W2093236229C71924100 @default.
- W2093236229 hasConceptScore W2093236229C78519656 @default.
- W2093236229 hasIssue "1" @default.
- W2093236229 hasLocation W20932362291 @default.
- W2093236229 hasLocation W20932362292 @default.
- W2093236229 hasOpenAccess W2093236229 @default.
- W2093236229 hasPrimaryLocation W20932362291 @default.
- W2093236229 hasRelatedWork W1967575823 @default.
- W2093236229 hasRelatedWork W1974083985 @default.
- W2093236229 hasRelatedWork W1992468615 @default.
- W2093236229 hasRelatedWork W2023756758 @default.
- W2093236229 hasRelatedWork W2027052432 @default.
- W2093236229 hasRelatedWork W2056690209 @default.
- W2093236229 hasRelatedWork W2070286483 @default.
- W2093236229 hasRelatedWork W2086628740 @default.
- W2093236229 hasRelatedWork W2120631068 @default.
- W2093236229 hasRelatedWork W2978823757 @default.
- W2093236229 hasVolume "1042" @default.
- W2093236229 isParatext "false" @default.
- W2093236229 isRetracted "false" @default.
- W2093236229 magId "2093236229" @default.
- W2093236229 workType "article" @default.