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• W2093238071 abstract "Glucose-induced insulin secretion from pancreatic β-cells involves metabolism-induced membrane depolarization and voltage-dependent Ca2+ influx. The electrical events in β-cell glucose sensing have been studied intensely using mouse islets of Langerhans, but data from other species, including models of type 2 diabetes mellitus (T2DM), are lacking. In this work, we made intracellular recordings of electrical activity from cells within islets of the gerbil Psammomys obesus (fat sand rat), a model of dietary-induced T2DM. Most islet cells from lean, non-diabetic sand rats displayed glucose-induced, KATP channel-dependent, oscillatory electrical activity that was similar to the classic “bursting” pattern of mouse β-cells. However, the oscillations were slower in sand rat islets, and the dose–response curve of electrical activity versus glucose concentration was left-shifted. Of the non-bursting cells, some produced action potentials continuously, while others displayed electrical activity that was largely independent of glucose. The latter activity consisted of continuous or intermittent action potential firing, and persisted for long periods in the absence of glucose. The glucose-insensitive activity was suppressed by diazoxide, indicating that the cells expressed KATP channels. Sand rat islets produced intracellular Ca2+ oscillations reminiscent of the oscillatory electrical pattern observed in most cells, albeit with a longer period. Finally, we found that the glucose dependence of insulin secretion from sand rat islets closely paralleled that of the bursting electrical activity. We conclude that while subpopulations of KATP-expressing cells in sand rat islets display heterogeneous electrical responses to glucose, insulin secretion most closely follows the oscillatory activity. The ease of recording membrane potential from sand rat islets makes this a useful model for studies of β-cell electrical signaling during the development of T2DM." @default.
• W2093238071 created "2016-06-24" @default.
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• W2093238071 date "2009-04-01" @default.
• W2093238071 modified "2023-09-23" @default.
• W2093238071 title "Glucose-dependent and -independent electrical activity in islets of Langerhans of Psammomys obesus, an animal model of nutritionally induced obesity and diabetes" @default.
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• W2093238071 doi "https://doi.org/10.1016/j.ygcen.2008.12.017" @default.
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