Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093260892> ?p ?o ?g. }
- W2093260892 endingPage "171" @default.
- W2093260892 startingPage "157" @default.
- W2093260892 abstract "Cux-1 is a murine homeobox gene that is highly expressed in the developing kidney with expression restricted to the nephrogenic zone. Cux-1 is highly expressed in cyst epithelium of polycystic kidneys from C57BL/6J-cpk/cpk mice, but not in kidneys isolated from age-matched phenotypically normal littermates. To further elucidate the role of Cux-1 in renal development, we generated transgenic mice expressing Cux-1 under the control of the CMV immediate early gene promoter. Mice constitutively expressing Cux-1 developed multiorgan hyperplasia and organomegaly, but not an overall increase in body size. Transgenic kidneys were enlarged 50% by 6 weeks of age, with the increased growth primarily restricted to the cortex. Proliferating cells were found in proximal and distal tubule epithelium throughout the cortex, and the squamous epithelium that normally lines Bowman's capsule was replaced with proximal tubule epithelium. However, the total number of nephrons was not increased. In the developing kidneys of transgenic mice, Cux-1 was ectopically expressed in more highly differentiated tubules and glomeruli, and this was associated with reduced expression of the cyclin kinase inhibitor, p27. Transient transfection experiments revealed that Cux-1 is an inhibitor of p27 promoter activity. These results suggest that Cux-1 regulates cell proliferation during early nephrogenesis by inhibiting expression of p27." @default.
- W2093260892 created "2016-06-24" @default.
- W2093260892 creator A5022800809 @default.
- W2093260892 creator A5031271572 @default.
- W2093260892 creator A5034274928 @default.
- W2093260892 creator A5039063866 @default.
- W2093260892 creator A5039822490 @default.
- W2093260892 creator A5041296778 @default.
- W2093260892 creator A5050373233 @default.
- W2093260892 creator A5060224758 @default.
- W2093260892 creator A5068471780 @default.
- W2093260892 creator A5081829033 @default.
- W2093260892 date "2002-05-01" @default.
- W2093260892 modified "2023-09-30" @default.
- W2093260892 title "Deregulated Expression of the Homeobox Gene Cux-1 in Transgenic Mice Results in Downregulation of p27kip1 Expression during Nephrogenesis, Glomerular Abnormalities, and Multiorgan Hyperplasia" @default.
- W2093260892 cites W1570393711 @default.
- W2093260892 cites W1596659824 @default.
- W2093260892 cites W1602266368 @default.
- W2093260892 cites W1607125092 @default.
- W2093260892 cites W170348712 @default.
- W2093260892 cites W1825663109 @default.
- W2093260892 cites W1923107379 @default.
- W2093260892 cites W1971689970 @default.
- W2093260892 cites W1974391793 @default.
- W2093260892 cites W1980123375 @default.
- W2093260892 cites W1982846145 @default.
- W2093260892 cites W1983228128 @default.
- W2093260892 cites W1987566228 @default.
- W2093260892 cites W1988171238 @default.
- W2093260892 cites W1989403326 @default.
- W2093260892 cites W1990848997 @default.
- W2093260892 cites W1996969679 @default.
- W2093260892 cites W1999876280 @default.
- W2093260892 cites W2002586328 @default.
- W2093260892 cites W2003604629 @default.
- W2093260892 cites W2006298768 @default.
- W2093260892 cites W2007271403 @default.
- W2093260892 cites W2015066175 @default.
- W2093260892 cites W2016160051 @default.
- W2093260892 cites W2016499189 @default.
- W2093260892 cites W2018183560 @default.
- W2093260892 cites W2018570422 @default.
- W2093260892 cites W2019316722 @default.
- W2093260892 cites W2021345772 @default.
- W2093260892 cites W2022574163 @default.
- W2093260892 cites W2023797553 @default.
- W2093260892 cites W2027322371 @default.
- W2093260892 cites W2029397182 @default.
- W2093260892 cites W2037330840 @default.
- W2093260892 cites W2037470216 @default.
- W2093260892 cites W2039309643 @default.
- W2093260892 cites W2043217551 @default.
- W2093260892 cites W2045042588 @default.
- W2093260892 cites W2048249977 @default.
- W2093260892 cites W2048672429 @default.
- W2093260892 cites W2051998916 @default.
- W2093260892 cites W2060744411 @default.
- W2093260892 cites W2062020285 @default.
- W2093260892 cites W2077840513 @default.
- W2093260892 cites W2078690152 @default.
- W2093260892 cites W2081290278 @default.
- W2093260892 cites W2083561654 @default.
- W2093260892 cites W2085365799 @default.
- W2093260892 cites W2085593164 @default.
- W2093260892 cites W2086365424 @default.
- W2093260892 cites W2086761475 @default.
- W2093260892 cites W2086918121 @default.
- W2093260892 cites W2087212540 @default.
- W2093260892 cites W2088424142 @default.
- W2093260892 cites W2089218510 @default.
- W2093260892 cites W2094859123 @default.
- W2093260892 cites W2104328711 @default.
- W2093260892 cites W2111563223 @default.
- W2093260892 cites W2114245705 @default.
- W2093260892 cites W2116711648 @default.
- W2093260892 cites W2118717572 @default.
- W2093260892 cites W2124415162 @default.
- W2093260892 cites W2124662269 @default.
- W2093260892 cites W2125159271 @default.
- W2093260892 cites W2134649995 @default.
- W2093260892 cites W2141329399 @default.
- W2093260892 cites W2143416290 @default.
- W2093260892 cites W2147182672 @default.
- W2093260892 cites W2149388963 @default.
- W2093260892 cites W2152534875 @default.
- W2093260892 cites W2158058087 @default.
- W2093260892 cites W2162415857 @default.
- W2093260892 cites W2165830726 @default.
- W2093260892 cites W2186225047 @default.
- W2093260892 cites W2289765832 @default.
- W2093260892 cites W2437428320 @default.
- W2093260892 cites W75161829 @default.
- W2093260892 cites W90751401 @default.
- W2093260892 doi "https://doi.org/10.1006/dbio.2002.0636" @default.
- W2093260892 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4454426" @default.
- W2093260892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11969263" @default.
- W2093260892 hasPublicationYear "2002" @default.
- W2093260892 type Work @default.