FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093273285> ?p ?o ?g. }

• W2093273285 endingPage "208" @default.
• W2093273285 startingPage "201" @default.
• W2093273285 abstract "An in vitro permeation study of ethyl nicotinate (EN) was carried out using excised hairless rat skin, and simultaneous skin transport and metabolism of the drug were kinetically followed. Fairly good steady-state fluxes of EN and its metabolite nicotinic acid (NA) through the skin were obtained after a short lag time for all the concentrations of EN applied. These steady-state fluxes were not proportional to the initial donor concentration of EN: EN and NA curves were concave and convex, respectively, which suggests that metabolic saturation from EN to NA takes place in the viable skin at higher EN application. Further permeation studies of EN or NA were then carried out on full-thickness skin or stripped skin with an esterase inhibitor to measure their permeation parameters, such as partition coefficient of EN from the donor solution to the stratum corneum and diffusion coefficients of EN and NA in the stratum corneum and the viable epidermis and dermis. Separately, enzymatic parameters (Michaelis constant K(m) and maximum metabolism rate V(max)) were obtained from the production rate of NA from different concentrations of EN in the skin homogenate. The obtained permeation and enzymatic parameters were then introduced to differential equations showing Fick's second law of diffusion in the stratum corneum and the law with Michaelis-Menten metabolism in the viable epidermis and dermis. The calculated steady-state fluxes of EN and NA by the equations were very close to the obtained data. We then measured the esterase distribution in skin microphotographically using fluorescein-5-isothiocyanate diacetate. A higher enzyme concentration was observed in the epidermal cells and near hair follicles than in the dermis. Simulation studies using the even and the partial enzyme distribution models suggested that no significant difference between the models was observed in the skin permeations of EN and NA, whereas concentration-distance profiles of EN and NA were very different. This finding suggests that the total amount of enzyme in skin which converts EN to NA is a determinant of the metabolic rate of EN in skin. The present approach is a useful tool for analyzing simultaneous transport and metabolism of many drugs, especially those showing Michaelis-Menten type-metabolic saturation in skin." @default.
• W2093273285 created "2016-06-24" @default.
• W2093273285 creator A5029618124 @default.
• W2093273285 creator A5038171028 @default.
• W2093273285 creator A5086954727 @default.
• W2093273285 date "1999-11-01" @default.
• W2093273285 modified "2023-10-13" @default.
• W2093273285 title "Simultaneous transport and metabolism of ethyl nicotinate in hairless rat skin after its topical application: the effect of enzyme distribution in skin" @default.
• W2093273285 cites W113202891 @default.
• W2093273285 cites W124097478 @default.
• W2093273285 cites W186237373 @default.
• W2093273285 cites W1974175829 @default.
• W2093273285 cites W1989446862 @default.
• W2093273285 cites W2003264270 @default.
• W2093273285 cites W2003735503 @default.
• W2093273285 cites W2053190965 @default.
• W2093273285 cites W2060425896 @default.
• W2093273285 cites W2064002203 @default.
• W2093273285 cites W2070879761 @default.
• W2093273285 cites W2135211075 @default.
• W2093273285 cites W290443146 @default.
• W2093273285 cites W60760072 @default.
• W2093273285 doi "https://doi.org/10.1016/s0168-3659(99)00039-5" @default.
• W2093273285 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10518652" @default.
• W2093273285 hasPublicationYear "1999" @default.
• W2093273285 type Work @default.
• W2093273285 sameAs 2093273285 @default.
• W2093273285 citedByCount "50" @default.
• W2093273285 countsByYear W20932732852012 @default.
• W2093273285 countsByYear W20932732852013 @default.
• W2093273285 countsByYear W20932732852014 @default.
• W2093273285 countsByYear W20932732852015 @default.
• W2093273285 countsByYear W20932732852016 @default.
• W2093273285 countsByYear W20932732852017 @default.
• W2093273285 countsByYear W20932732852018 @default.
• W2093273285 countsByYear W20932732852019 @default.
• W2093273285 countsByYear W20932732852023 @default.
• W2093273285 crossrefType "journal-article" @default.
• W2093273285 hasAuthorship W2093273285A5029618124 @default.
• W2093273285 hasAuthorship W2093273285A5038171028 @default.
• W2093273285 hasAuthorship W2093273285A5086954727 @default.
• W2093273285 hasConcept C105702510 @default.
• W2093273285 hasConcept C121332964 @default.
• W2093273285 hasConcept C12554922 @default.
• W2093273285 hasConcept C178790620 @default.
• W2093273285 hasConcept C185592680 @default.
• W2093273285 hasConcept C192552737 @default.
• W2093273285 hasConcept C2777624698 @default.
• W2093273285 hasConcept C2778370115 @default.
• W2093273285 hasConcept C2779156968 @default.
• W2093273285 hasConcept C41625074 @default.
• W2093273285 hasConcept C43617362 @default.
• W2093273285 hasConcept C50670333 @default.
• W2093273285 hasConcept C54355233 @default.
• W2093273285 hasConcept C55493867 @default.
• W2093273285 hasConcept C69357855 @default.
• W2093273285 hasConcept C8171440 @default.
• W2093273285 hasConcept C86803240 @default.
• W2093273285 hasConcept C97355855 @default.
• W2093273285 hasConceptScore W2093273285C105702510 @default.
• W2093273285 hasConceptScore W2093273285C121332964 @default.
• W2093273285 hasConceptScore W2093273285C12554922 @default.
• W2093273285 hasConceptScore W2093273285C178790620 @default.
• W2093273285 hasConceptScore W2093273285C185592680 @default.
• W2093273285 hasConceptScore W2093273285C192552737 @default.
• W2093273285 hasConceptScore W2093273285C2777624698 @default.
• W2093273285 hasConceptScore W2093273285C2778370115 @default.
• W2093273285 hasConceptScore W2093273285C2779156968 @default.
• W2093273285 hasConceptScore W2093273285C41625074 @default.
• W2093273285 hasConceptScore W2093273285C43617362 @default.
• W2093273285 hasConceptScore W2093273285C50670333 @default.
• W2093273285 hasConceptScore W2093273285C54355233 @default.
• W2093273285 hasConceptScore W2093273285C55493867 @default.
• W2093273285 hasConceptScore W2093273285C69357855 @default.
• W2093273285 hasConceptScore W2093273285C8171440 @default.
• W2093273285 hasConceptScore W2093273285C86803240 @default.
• W2093273285 hasConceptScore W2093273285C97355855 @default.
• W2093273285 hasIssue "1-2" @default.
• W2093273285 hasLocation W20932732851 @default.
• W2093273285 hasLocation W20932732852 @default.
• W2093273285 hasOpenAccess W2093273285 @default.
• W2093273285 hasPrimaryLocation W20932732851 @default.
• W2093273285 hasRelatedWork W1092229866 @default.
• W2093273285 hasRelatedWork W1956027365 @default.
• W2093273285 hasRelatedWork W1993894665 @default.
• W2093273285 hasRelatedWork W2063459472 @default.
• W2093273285 hasRelatedWork W2069508487 @default.
• W2093273285 hasRelatedWork W2077763483 @default.
• W2093273285 hasRelatedWork W2142262484 @default.
• W2093273285 hasRelatedWork W2367566586 @default.
• W2093273285 hasRelatedWork W2370601373 @default.
• W2093273285 hasRelatedWork W601922926 @default.
• W2093273285 hasVolume "62" @default.
• W2093273285 isParatext "false" @default.
• W2093273285 isRetracted "false" @default.
• W2093273285 magId "2093273285" @default.
• W2093273285 workType "article" @default.