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• W2093274424 abstract "Di(3-thienyl)methanol (2) and di(3-thienyl)methane (3) have been synthesized and screened against the T98G (brain cancer) cell line. Treatment induced cell death (MTT and macro-colony assay), growth inhibition, cytogenetic damage (micronuclei formation), were studied as cellular response parameters. Treatment with the compounds enhanced growth inhibition and cell death in a concentration dependent manner in both T98G and HEK (normal) cell lines. At higher concentrations (>20 µg/mL) the cytotoxic effects of the compounds were highly significant. The effect on clonogenic capacity and micronuclei formation observed after treatment of cells. Amongst the compounds, compound 2 exhibited potent activity against T98G brain cancer cells. Despite potent in vitro activity, both compounds exhibited less cytotoxicity against normal human HEK cells at all effective concentrations." @default.
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• W2093274424 date "2012-09-27" @default.
• W2093274424 modified "2023-10-09" @default.
• W2093274424 title "Synthesis and Anticancer Activity of Di(3-thienyl)methanol and Di(3-thienyl)methane" @default.
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• W2093274424 doi "https://doi.org/10.3390/molecules171011456" @default.
• W2093274424 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6268370" @default.
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