Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093275810> ?p ?o ?g. }
- W2093275810 endingPage "681" @default.
- W2093275810 startingPage "673" @default.
- W2093275810 abstract "A marked increase in the utilization of umbilical cord blood (UCB) transplantation has been observed in recent years; however, the use of UCB as a hematopoietic stem cell (HSC) source is limited primarily by the number of progenitor cells contained in the graft. Graft failure, delayed engraftment and profound delay in immune reconstitution lead to significant morbidity and mortality in adults. The lack of cells available for post transplant therapies, such as donor lymphocyte infusions, has also been considered to be a disadvantage of UCB. To improve outcomes and extend applicability of UCB transplantation, one potential solution is ex vivo expansion of UCB. Investigators have used several methods, including liquid suspension culture with various cytokines and expansion factors, co-culture with stromal elements and continuous perfusion systems. Techniques combining ex vivo expanded and unmanipulated UCB are being explored to optimize the initial engraftment kinetics as well as the long-term durability. The optimal expansion conditions are still not known; however, recent studies suggest that expanded UCB is safe. It is hoped that by ex vivo expansion of UCB, a resulting decrease in the morbidity and mortality of UCB transplantation will be observed, and that the availability of additional cells may allow adoptive immunotherapy or gene transfer therapies in the UCB setting." @default.
- W2093275810 created "2016-06-24" @default.
- W2093275810 creator A5015996246 @default.
- W2093275810 creator A5034264716 @default.
- W2093275810 creator A5055885795 @default.
- W2093275810 creator A5076377592 @default.
- W2093275810 date "2009-10-05" @default.
- W2093275810 modified "2023-10-06" @default.
- W2093275810 title "Ex vivo expansion of cord blood" @default.
- W2093275810 cites W108816917 @default.
- W2093275810 cites W109001291 @default.
- W2093275810 cites W1265257573 @default.
- W2093275810 cites W1504115723 @default.
- W2093275810 cites W1550741318 @default.
- W2093275810 cites W1582631769 @default.
- W2093275810 cites W1600303699 @default.
- W2093275810 cites W1906638117 @default.
- W2093275810 cites W1964015260 @default.
- W2093275810 cites W1965404871 @default.
- W2093275810 cites W1965671668 @default.
- W2093275810 cites W1966100365 @default.
- W2093275810 cites W1970147597 @default.
- W2093275810 cites W1970291858 @default.
- W2093275810 cites W1975025595 @default.
- W2093275810 cites W1976471114 @default.
- W2093275810 cites W1977253353 @default.
- W2093275810 cites W1978625395 @default.
- W2093275810 cites W1978979017 @default.
- W2093275810 cites W1981032020 @default.
- W2093275810 cites W1982110551 @default.
- W2093275810 cites W1982408656 @default.
- W2093275810 cites W1985398394 @default.
- W2093275810 cites W1991150541 @default.
- W2093275810 cites W1993593067 @default.
- W2093275810 cites W1995001988 @default.
- W2093275810 cites W1995365460 @default.
- W2093275810 cites W1997743593 @default.
- W2093275810 cites W1998279031 @default.
- W2093275810 cites W2002650695 @default.
- W2093275810 cites W2003339708 @default.
- W2093275810 cites W2008028335 @default.
- W2093275810 cites W2008440336 @default.
- W2093275810 cites W2009417720 @default.
- W2093275810 cites W2017532079 @default.
- W2093275810 cites W2017574470 @default.
- W2093275810 cites W2019913649 @default.
- W2093275810 cites W2025716311 @default.
- W2093275810 cites W2030194874 @default.
- W2093275810 cites W2033716778 @default.
- W2093275810 cites W2036032096 @default.
- W2093275810 cites W2036933277 @default.
- W2093275810 cites W2037770900 @default.
- W2093275810 cites W2039192227 @default.
- W2093275810 cites W2039269834 @default.
- W2093275810 cites W2047003816 @default.
- W2093275810 cites W2056032632 @default.
- W2093275810 cites W2060271699 @default.
- W2093275810 cites W2062915300 @default.
- W2093275810 cites W2064440568 @default.
- W2093275810 cites W2065845167 @default.
- W2093275810 cites W2066473451 @default.
- W2093275810 cites W2066612974 @default.
- W2093275810 cites W2069006548 @default.
- W2093275810 cites W2069078768 @default.
- W2093275810 cites W2069182053 @default.
- W2093275810 cites W2070990833 @default.
- W2093275810 cites W2079762668 @default.
- W2093275810 cites W2080008757 @default.
- W2093275810 cites W2080878594 @default.
- W2093275810 cites W2085516849 @default.
- W2093275810 cites W2086793358 @default.
- W2093275810 cites W2087124418 @default.
- W2093275810 cites W2087353148 @default.
- W2093275810 cites W2088500471 @default.
- W2093275810 cites W2089426706 @default.
- W2093275810 cites W2090051716 @default.
- W2093275810 cites W2090529961 @default.
- W2093275810 cites W2092353589 @default.
- W2093275810 cites W2096089376 @default.
- W2093275810 cites W2096830914 @default.
- W2093275810 cites W2104801598 @default.
- W2093275810 cites W2109838255 @default.
- W2093275810 cites W2112619023 @default.
- W2093275810 cites W2115833446 @default.
- W2093275810 cites W2120208604 @default.
- W2093275810 cites W2124101680 @default.
- W2093275810 cites W2125151734 @default.
- W2093275810 cites W2129321368 @default.
- W2093275810 cites W2131292600 @default.
- W2093275810 cites W2138794212 @default.
- W2093275810 cites W2139485932 @default.
- W2093275810 cites W2143182768 @default.
- W2093275810 cites W2146924285 @default.
- W2093275810 cites W2148842379 @default.
- W2093275810 cites W2149176302 @default.
- W2093275810 cites W2150384215 @default.
- W2093275810 cites W2157265657 @default.
- W2093275810 cites W2159310677 @default.