FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093283338> ?p ?o ?g. }

• W2093283338 endingPage "551" @default.
• W2093283338 startingPage "531" @default.
• W2093283338 abstract "Abstract It was shown that IgGs from the sera of 2–7‐month‐old control non‐autoimmune (CBA x C57BL)F1 and BALB/c mice and 2–3‐month‐old autoimmune prone MRL‐lpr/lpr mice (conditionally healthy mice) are catalytically inactive. During spontaneous development of deep systemic lupus erythematosus (SLE)‐like pathology a specific reorganization of immune system of these mice leads to conditions associated with a production of IgGs hydrolyzing DNA, ATP and polysaccharides with low catalytic activities (conditionally pre‐diseased mice).A significant increase in DNase, ATPase and amylase IgG relative activities associated with a transition from pre‐diseased to deep diseased mice is correlated with additional changes in differentiation and proliferation of mice bone marrow haematopoietic stem cells (HSCs) and lymphocyte proliferation in different organs.The highest increase in all abzyme activities was found in mice immunized with DNA, which in comparison with pre‐diseased and diseased mice are characterized by a different profile of HSC differentiation and by a suppression of cell apoptosis. Abzyme activities in the serum of pregnant females were comparable with those for pre‐diseased mice, but the profile of HSC differentiation and cell apoptosis levels in pregnant and pre‐diseased mice were quite different. Right after the beginning of lactation (4 days after delivery) and in a late time of lactation (14 days after delivery) there was an observed increase in cell apoptosis and two different stages of significant change in the HSC differentiation profiles; the first stage was accompanied with a significant increase and the second with a remarkable decrease in abzyme activities. Overall, all mouse groups investigated are characterized by a specific relationship between abzyme activities, HSC differentiation profiles, levels of lymphocyte proliferation, and cell apoptosis in different organs. From our point of view, the appearance of ATPase, DNase activities may be considered the earliest statistically significant marker of mouse spontaneous SLE and a further significant increase in their activities correlates with the appearance of SLE visible markers and with an increase in concentrations of anti‐DNA Abs and urine protein. However, development of autoimmune (AI)‐reactions and the increase in the sera anti‐DNA antibodies (Abs) and in the abzyme activities in pregnant and lactating mice do not associate with SLE visible markers and proteinuria. The possible differences in immune system reorganizations during pre‐disease, disease, pregnancy and lactation leading to production of different auto‐antibodies and abzymes are discussed." @default.
• W2093283338 created "2016-06-24" @default.
• W2093283338 creator A5024424487 @default.
• W2093283338 creator A5025983549 @default.
• W2093283338 creator A5036757787 @default.
• W2093283338 creator A5040928701 @default.
• W2093283338 creator A5049045140 @default.
• W2093283338 creator A5051076208 @default.
• W2093283338 creator A5069435192 @default.
• W2093283338 creator A5081504559 @default.
• W2093283338 creator A5087383409 @default.
• W2093283338 date "2007-05-01" @default.
• W2093283338 modified "2023-10-16" @default.
• W2093283338 title "Formation of different abzymes in autoimmune-prone MRL-lpr/lpr mice is associated with changes in colony formation of haematopoietic progenitors" @default.
• W2093283338 cites W1487679163 @default.
• W2093283338 cites W1510002621 @default.
• W2093283338 cites W1824817514 @default.
• W2093283338 cites W187511776 @default.
• W2093283338 cites W1964981041 @default.
• W2093283338 cites W1966910789 @default.
• W2093283338 cites W1969506034 @default.
• W2093283338 cites W1969862662 @default.
• W2093283338 cites W1976453566 @default.
• W2093283338 cites W1976960376 @default.
• W2093283338 cites W1979129905 @default.
• W2093283338 cites W1981387238 @default.
• W2093283338 cites W1981601751 @default.
• W2093283338 cites W1987479282 @default.
• W2093283338 cites W1990986140 @default.
• W2093283338 cites W1991212304 @default.
• W2093283338 cites W1991345770 @default.
• W2093283338 cites W1996735107 @default.
• W2093283338 cites W1998756793 @default.
• W2093283338 cites W1999523219 @default.
• W2093283338 cites W2001538424 @default.
• W2093283338 cites W2004905016 @default.
• W2093283338 cites W2007028174 @default.
• W2093283338 cites W2007926170 @default.
• W2093283338 cites W2013257987 @default.
• W2093283338 cites W2022191003 @default.
• W2093283338 cites W2028111124 @default.
• W2093283338 cites W2036312463 @default.
• W2093283338 cites W2037262823 @default.
• W2093283338 cites W2041406520 @default.
• W2093283338 cites W2042293405 @default.
• W2093283338 cites W2050939959 @default.
• W2093283338 cites W2051165942 @default.
• W2093283338 cites W2068423037 @default.
• W2093283338 cites W2072695170 @default.
• W2093283338 cites W2083106799 @default.
• W2093283338 cites W2090532172 @default.
• W2093283338 cites W2092630964 @default.
• W2093283338 cites W2102707071 @default.
• W2093283338 cites W2106656550 @default.
• W2093283338 cites W2113540628 @default.
• W2093283338 cites W2127347361 @default.
• W2093283338 cites W2157245015 @default.
• W2093283338 cites W2272860173 @default.
• W2093283338 cites W2398014496 @default.
• W2093283338 cites W2408196880 @default.
• W2093283338 cites W2410600214 @default.
• W2093283338 cites W2413102876 @default.
• W2093283338 cites W2416045305 @default.
• W2093283338 cites W2436742007 @default.
• W2093283338 cites W4251951372 @default.
• W2093283338 cites W62771806 @default.
• W2093283338 doi "https://doi.org/10.1111/j.1582-4934.2007.00048.x" @default.
• W2093283338 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3922359" @default.
• W2093283338 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17635644" @default.
• W2093283338 hasPublicationYear "2007" @default.
• W2093283338 type Work @default.
• W2093283338 sameAs 2093283338 @default.
• W2093283338 citedByCount "50" @default.
• W2093283338 countsByYear W20932833382012 @default.
• W2093283338 countsByYear W20932833382013 @default.
• W2093283338 countsByYear W20932833382014 @default.
• W2093283338 countsByYear W20932833382015 @default.
• W2093283338 countsByYear W20932833382016 @default.
• W2093283338 countsByYear W20932833382017 @default.
• W2093283338 countsByYear W20932833382018 @default.
• W2093283338 countsByYear W20932833382019 @default.
• W2093283338 countsByYear W20932833382020 @default.
• W2093283338 countsByYear W20932833382021 @default.
• W2093283338 countsByYear W20932833382022 @default.
• W2093283338 countsByYear W20932833382023 @default.
• W2093283338 crossrefType "journal-article" @default.
• W2093283338 hasAuthorship W2093283338A5024424487 @default.
• W2093283338 hasAuthorship W2093283338A5025983549 @default.
• W2093283338 hasAuthorship W2093283338A5036757787 @default.
• W2093283338 hasAuthorship W2093283338A5040928701 @default.
• W2093283338 hasAuthorship W2093283338A5049045140 @default.
• W2093283338 hasAuthorship W2093283338A5051076208 @default.
• W2093283338 hasAuthorship W2093283338A5069435192 @default.
• W2093283338 hasAuthorship W2093283338A5081504559 @default.
• W2093283338 hasAuthorship W2093283338A5087383409 @default.
• W2093283338 hasBestOaLocation W20932833381 @default.
• W2093283338 hasConcept C109159458 @default.
• W2093283338 hasConcept C153911025 @default.

• next