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- W2093287744 abstract "Epithelial tubes are the infrastructure for organs and tissues, and tube morphogenesis requires precise orchestration of cell signaling, shape, migration, and adhesion. Follicle cells in the Drosophila ovary form a pair of epithelial tubes whose lumens act as molds for the eggshell respiratory filaments, or dorsal appendages (DAs). DA formation is a robust and accessible model for studying the patterning, formation, and expansion of epithelial tubes. Tramtrack69 (TTK69), a transcription factor that exhibits a variable embryonic DNA-binding preference, controls DA lumen volume and shape by promoting tube expansion; the tramtrack mutation twin peaks (ttk(twk)) reduces TTK69 levels late in oogenesis, inhibiting this expansion. Microarray analysis of wild-type and ttk(twk) ovaries, followed by in situ hybridization and RNAi of candidate genes, identified the Phospholipase B-like protein Lamina ancestor (LAMA), the scaffold protein Paxillin, the endocytotic regulator Shibire (Dynamin), and the homeodomain transcription factor Mirror, as TTK69 effectors of DA-tube expansion. These genes displayed enriched expression in DA-tube cells, except lama, which was expressed in all follicle cells. All four genes showed reduced expression in ttk(twk) mutants and exhibited RNAi phenotypes that were enhanced in a ttk(twk)/+ background, indicating ttk(twk) genetic interactions. Although previous studies show that Mirror patterns the follicular epithelium prior to DA tubulogenesis, we show that Mirror has an independent, novel role in tube expansion, involving positive regulation of Paxillin. Thus, characterization of ttk(twk)-differentially expressed genes expands the network of TTK69 effectors, identifies novel epithelial tube-expansion regulators, and significantly advances our understanding of this vital developmental process." @default.
- W2093287744 created "2016-06-24" @default.
- W2093287744 creator A5008676408 @default.
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- W2093287744 creator A5064524144 @default.
- W2093287744 creator A5067588572 @default.
- W2093287744 date "2013-06-01" @default.
- W2093287744 modified "2023-09-26" @default.
- W2093287744 title "Following the ‘tracks’: Tramtrack69 regulates epithelial tube expansion in the Drosophila ovary through Paxillin, Dynamin, and the homeobox protein Mirror" @default.
- W2093287744 cites W1225109155 @default.
- W2093287744 cites W158744650 @default.
- W2093287744 cites W1599560675 @default.
- W2093287744 cites W1936346288 @default.
- W2093287744 cites W1968659811 @default.
- W2093287744 cites W1970914997 @default.
- W2093287744 cites W1974331467 @default.
- W2093287744 cites W1983707693 @default.
- W2093287744 cites W1985230382 @default.
- W2093287744 cites W1987078237 @default.
- W2093287744 cites W1988938223 @default.
- W2093287744 cites W1991810324 @default.
- W2093287744 cites W1995100972 @default.
- W2093287744 cites W1995345065 @default.
- W2093287744 cites W1998966102 @default.
- W2093287744 cites W2001884508 @default.
- W2093287744 cites W2009110191 @default.
- W2093287744 cites W2011371821 @default.
- W2093287744 cites W2016332660 @default.
- W2093287744 cites W2017085487 @default.
- W2093287744 cites W2017995506 @default.
- W2093287744 cites W2020541351 @default.
- W2093287744 cites W2022731004 @default.
- W2093287744 cites W2027298582 @default.
- W2093287744 cites W2030274279 @default.
- W2093287744 cites W2031338420 @default.
- W2093287744 cites W2033780586 @default.
- W2093287744 cites W2035288422 @default.
- W2093287744 cites W2042328334 @default.
- W2093287744 cites W2043402517 @default.
- W2093287744 cites W2043856491 @default.
- W2093287744 cites W2044532235 @default.
- W2093287744 cites W2044854823 @default.
- W2093287744 cites W2045485235 @default.
- W2093287744 cites W2054754289 @default.
- W2093287744 cites W2056129229 @default.
- W2093287744 cites W2056769481 @default.
- W2093287744 cites W2058170261 @default.
- W2093287744 cites W2058840021 @default.
- W2093287744 cites W2060232328 @default.
- W2093287744 cites W2065825538 @default.
- W2093287744 cites W2073094091 @default.
- W2093287744 cites W2073204066 @default.
- W2093287744 cites W2083476264 @default.
- W2093287744 cites W2084191969 @default.
- W2093287744 cites W2086309553 @default.
- W2093287744 cites W2086643670 @default.
- W2093287744 cites W2088338862 @default.
- W2093287744 cites W2089667995 @default.
- W2093287744 cites W2094493435 @default.
- W2093287744 cites W2096658690 @default.
- W2093287744 cites W2097248018 @default.
- W2093287744 cites W2097378900 @default.
- W2093287744 cites W2103116478 @default.
- W2093287744 cites W2106467103 @default.
- W2093287744 cites W2108770100 @default.
- W2093287744 cites W2110643873 @default.
- W2093287744 cites W2112258991 @default.
- W2093287744 cites W2112355295 @default.
- W2093287744 cites W2112418598 @default.
- W2093287744 cites W2113508405 @default.
- W2093287744 cites W2115867240 @default.
- W2093287744 cites W2117465360 @default.
- W2093287744 cites W2132582653 @default.
- W2093287744 cites W2144044677 @default.
- W2093287744 cites W2144941304 @default.
- W2093287744 cites W2148745843 @default.
- W2093287744 cites W2150972545 @default.
- W2093287744 cites W2157009395 @default.
- W2093287744 cites W2161154819 @default.
- W2093287744 cites W2164361524 @default.
- W2093287744 cites W2167194725 @default.
- W2093287744 cites W2170984431 @default.
- W2093287744 cites W2187732153 @default.
- W2093287744 cites W2187952665 @default.
- W2093287744 cites W2322037963 @default.
- W2093287744 cites W285723765 @default.
- W2093287744 cites W4236498790 @default.
- W2093287744 doi "https://doi.org/10.1016/j.ydbio.2013.03.017" @default.
- W2093287744 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4141043" @default.
- W2093287744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23545328" @default.
- W2093287744 hasPublicationYear "2013" @default.
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