FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093292016> ?p ?o ?g. }

• W2093292016 endingPage "465" @default.
• W2093292016 startingPage "457" @default.
• W2093292016 abstract "A longstanding hypothesis proposes that amyotrophic lateral sclerosis-motor neurone disease (ALS-MND) is a late consequence of subclinical poliovirus (PV) infection. In this study, RNA extracts of CNS tissue from 28 patients with ALS-MND and 7 controls were assayed by nested polymerase chain reaction (PCR) using primers to the 5′-untranslated region (UTR) of the enterovirus (EV) genome which is highly conserved between EVs including PV, echovirus and coxsackie viruses. The integrity of RNA extracted from either archival paraffin-embedded or frozen CNS tissue was assessed by detection of constitutive Ableson tyrosine kinase (ABL) mRNA by PCR. Of 63 tissue samples assayed, 81% () were ABL-positive corresponding to 78% () of the ALS-MND cases and all controls. None of the 27 ALS-MND cases (i.e. 21 ABL+ and 6 ABL−) in which paraffin-embedded tissue was used nor any of the age and sex matched controls were positive for specific PV/EV RNA. Moreover, CNS tissue from 14 different locations obtained from one patient < 2 hrs after death and immediately frozen, showed no evidence of PV/EV at any site by PCR. Disease duration, degree of tissue autolysis and duration of tissue storage were all excluded as factors which may predispose to negative results. The sensitivity of the PV PCR was determined to be 40–400 copies (12.5–125 ag) of synthetic EV RNA transcripts in i gg of cellular RNA and the assay was shown to detect all types of PV and other EVs tested. Thus it seems unlikely that a persistent PV or related EV infection is implicated in ALS-MND unless there has been alteration in the 5′-UTR of the virus genome." @default.
• W2093292016 created "2016-06-24" @default.
• W2093292016 creator A5008704373 @default.
• W2093292016 creator A5066543911 @default.
• W2093292016 creator A5022346272 @default.
• W2093292016 date "1995-11-01" @default.
• W2093292016 modified "2023-09-25" @default.
• W2093292016 title "Search for persistent infection with poliovirus or other enteroviruses in amyotrophic lateral sclerosis-motor neurone disease" @default.
• W2093292016 cites W1735834838 @default.
• W2093292016 cites W1971809076 @default.
• W2093292016 cites W1977108888 @default.
• W2093292016 cites W1988642048 @default.
• W2093292016 cites W1993950684 @default.
• W2093292016 cites W2004831310 @default.
• W2093292016 cites W2011733753 @default.
• W2093292016 cites W2017372751 @default.
• W2093292016 cites W2027088720 @default.
• W2093292016 cites W2028162090 @default.
• W2093292016 cites W2029734203 @default.
• W2093292016 cites W2037263220 @default.
• W2093292016 cites W2044509282 @default.
• W2093292016 cites W2047480444 @default.
• W2093292016 cites W2051053341 @default.
• W2093292016 cites W2056054733 @default.
• W2093292016 cites W2058118495 @default.
• W2093292016 cites W2071161697 @default.
• W2093292016 cites W2078560239 @default.
• W2093292016 cites W2089152267 @default.
• W2093292016 cites W210039449 @default.
• W2093292016 cites W2108119078 @default.
• W2093292016 cites W2122154152 @default.
• W2093292016 cites W2128888000 @default.
• W2093292016 cites W2143585898 @default.
• W2093292016 cites W2159747609 @default.
• W2093292016 cites W30731706 @default.
• W2093292016 doi "https://doi.org/10.1016/0960-8966(95)00002-5" @default.
• W2093292016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8580727" @default.
• W2093292016 hasPublicationYear "1995" @default.
• W2093292016 type Work @default.
• W2093292016 sameAs 2093292016 @default.
• W2093292016 citedByCount "29" @default.
• W2093292016 countsByYear W20932920162013 @default.
• W2093292016 countsByYear W20932920162015 @default.
• W2093292016 countsByYear W20932920162018 @default.
• W2093292016 countsByYear W20932920162019 @default.
• W2093292016 countsByYear W20932920162020 @default.
• W2093292016 countsByYear W20932920162021 @default.
• W2093292016 countsByYear W20932920162022 @default.
• W2093292016 crossrefType "journal-article" @default.
• W2093292016 hasAuthorship W2093292016A5008704373 @default.
• W2093292016 hasAuthorship W2093292016A5022346272 @default.
• W2093292016 hasAuthorship W2093292016A5066543911 @default.
• W2093292016 hasConcept C104317684 @default.
• W2093292016 hasConcept C112190416 @default.
• W2093292016 hasConcept C113280763 @default.
• W2093292016 hasConcept C142724271 @default.
• W2093292016 hasConcept C159047783 @default.
• W2093292016 hasConcept C2522874641 @default.
• W2093292016 hasConcept C2777888124 @default.
• W2093292016 hasConcept C2778819740 @default.
• W2093292016 hasConcept C2779134260 @default.
• W2093292016 hasConcept C2779631682 @default.
• W2093292016 hasConcept C2780596555 @default.
• W2093292016 hasConcept C48023723 @default.
• W2093292016 hasConcept C49105822 @default.
• W2093292016 hasConcept C54355233 @default.
• W2093292016 hasConcept C67705224 @default.
• W2093292016 hasConcept C71924100 @default.
• W2093292016 hasConcept C86803240 @default.
• W2093292016 hasConceptScore W2093292016C104317684 @default.
• W2093292016 hasConceptScore W2093292016C112190416 @default.
• W2093292016 hasConceptScore W2093292016C113280763 @default.
• W2093292016 hasConceptScore W2093292016C142724271 @default.
• W2093292016 hasConceptScore W2093292016C159047783 @default.
• W2093292016 hasConceptScore W2093292016C2522874641 @default.
• W2093292016 hasConceptScore W2093292016C2777888124 @default.
• W2093292016 hasConceptScore W2093292016C2778819740 @default.
• W2093292016 hasConceptScore W2093292016C2779134260 @default.
• W2093292016 hasConceptScore W2093292016C2779631682 @default.
• W2093292016 hasConceptScore W2093292016C2780596555 @default.
• W2093292016 hasConceptScore W2093292016C48023723 @default.
• W2093292016 hasConceptScore W2093292016C49105822 @default.
• W2093292016 hasConceptScore W2093292016C54355233 @default.
• W2093292016 hasConceptScore W2093292016C67705224 @default.
• W2093292016 hasConceptScore W2093292016C71924100 @default.
• W2093292016 hasConceptScore W2093292016C86803240 @default.
• W2093292016 hasIssue "6" @default.
• W2093292016 hasLocation W20932920161 @default.
• W2093292016 hasLocation W20932920162 @default.
• W2093292016 hasOpenAccess W2093292016 @default.
• W2093292016 hasPrimaryLocation W20932920161 @default.
• W2093292016 hasRelatedWork W1599532661 @default.
• W2093292016 hasRelatedWork W1989811521 @default.
• W2093292016 hasRelatedWork W2001317398 @default.
• W2093292016 hasRelatedWork W2039236901 @default.
• W2093292016 hasRelatedWork W2055463868 @default.
• W2093292016 hasRelatedWork W2064399553 @default.
• W2093292016 hasRelatedWork W2093292016 @default.

• next