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- W2093304844 abstract "The binding of CD40 ligand (CD40L) to CD40 stimulates inflammatory processes including the release of proinflammatory cytokines and the expression of adhesion molecules implying a role in atherosclerosis. Patients exhibiting hypercholesterolemia, unstable angina, or acute myocardial infarction present with increased CD40L levels. Novel data suggest that elevated soluble CD40L levels not only represent a risk factor for cardiovascular disease but also predict future adverse events, especially in patients with acute coronary syndromes (ACS). Examination of the potential role of the genetic variability on CD40/CD40L genes in ACS, as regards the regulation of CD40L, appears to be of great interest. Moreover, several therapeutic approaches such as statins, antihypertensive agents, and antiplatelet agents have been suggested as potential modulators of CD40L levels anticipating a positive impact on the outcomes of patients with ACS. Whether specific agents target the CD40/CD40L system as well as its pathogenic role in ACS remains to be elucidated by large-scale studies in the future." @default.
- W2093304844 created "2016-06-24" @default.
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- W2093304844 date "2010-07-01" @default.
- W2093304844 modified "2023-10-17" @default.
- W2093304844 title "From Atherosclerosis to Acute Coronary Syndromes: The Role of Soluble CD40 Ligand" @default.
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- W2093304844 doi "https://doi.org/10.1016/j.tcm.2010.12.004" @default.
- W2093304844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21742271" @default.