FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093306312> ?p ?o ?g. }

• W2093306312 endingPage "1508" @default.
• W2093306312 startingPage "1499" @default.
• W2093306312 abstract "In this study, molecular simulations have been combined with site-directed mutagenesis experiments to explore M398(2.43), a LH (lutropin) receptor (LHR) site in helix 2 susceptible to spontaneous activating mutations, and to develop a computational tool for predicting the functionality (i.e. active or nonactive) of LHR mutants.Site-directed mutagenesis experiments engineered 15 different substitutions for M389(2.43), which resulted in variable levels of constitutive activity, inversely correlated with the size of the replacing amino acid. This inverse correlation is suggested to be mediated by I460(3.46), M571(6.37), and Y623(7.53), the tyrosine of the NPxxY motif. In fact, size reduction at position 398(2.43), which is concurrent with constitutive receptor activity, releases the van der Waals interactions found in the wild-type LHR between M398(2.43) and these three amino acids, resulting in structural modifications in the proximity to the E/DRY/W motif. An increment, above a threshold value, in the solvent accessibility of the cytosolic ends of helices 3 and 6 is the main structural feature shared by the active mutants of the LHR. This feature has been successfully used for predicting the functionality of the engineered mutants at M398(2.43), proving that molecular simulations can be useful for in silico screening of LHR mutants." @default.
• W2093306312 created "2016-06-24" @default.
• W2093306312 creator A5028261391 @default.
• W2093306312 creator A5029369714 @default.
• W2093306312 creator A5062739266 @default.
• W2093306312 creator A5066926133 @default.
• W2093306312 creator A5070237066 @default.
• W2093306312 creator A5077993878 @default.
• W2093306312 date "2004-06-01" @default.
• W2093306312 modified "2023-09-27" @default.
• W2093306312 title "Insight into Mutation-Induced Activation of the Luteinizing Hormone Receptor: Molecular Simulations Predict the Functional Behavior of Engineered Mutants at M398" @default.
• W2093306312 cites W1496906644 @default.
• W2093306312 cites W1833104430 @default.
• W2093306312 cites W1954929088 @default.
• W2093306312 cites W1985937682 @default.
• W2093306312 cites W1991990669 @default.
• W2093306312 cites W1993677150 @default.
• W2093306312 cites W1998013652 @default.
• W2093306312 cites W1998861020 @default.
• W2093306312 cites W1999679806 @default.
• W2093306312 cites W2000007478 @default.
• W2093306312 cites W2005417512 @default.
• W2093306312 cites W2020644553 @default.
• W2093306312 cites W2026005641 @default.
• W2093306312 cites W2033766852 @default.
• W2093306312 cites W2034105003 @default.
• W2093306312 cites W2045785403 @default.
• W2093306312 cites W2046351772 @default.
• W2093306312 cites W2052998793 @default.
• W2093306312 cites W2065283382 @default.
• W2093306312 cites W2066964651 @default.
• W2093306312 cites W2071587854 @default.
• W2093306312 cites W2094119263 @default.
• W2093306312 cites W2133344686 @default.
• W2093306312 cites W2149218006 @default.
• W2093306312 cites W2149963584 @default.
• W2093306312 cites W2159723327 @default.
• W2093306312 cites W2160329901 @default.
• W2093306312 cites W2162166182 @default.
• W2093306312 cites W2164074867 @default.
• W2093306312 cites W2166316892 @default.
• W2093306312 cites W2338218840 @default.
• W2093306312 cites W2767182304 @default.
• W2093306312 cites W2951263156 @default.
• W2093306312 doi "https://doi.org/10.1210/me.2003-0050" @default.
• W2093306312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15016840" @default.
• W2093306312 hasPublicationYear "2004" @default.
• W2093306312 type Work @default.
• W2093306312 sameAs 2093306312 @default.
• W2093306312 citedByCount "32" @default.
• W2093306312 countsByYear W20933063122012 @default.
• W2093306312 countsByYear W20933063122013 @default.
• W2093306312 countsByYear W20933063122014 @default.
• W2093306312 countsByYear W20933063122016 @default.
• W2093306312 countsByYear W20933063122018 @default.
• W2093306312 countsByYear W20933063122019 @default.
• W2093306312 countsByYear W20933063122020 @default.
• W2093306312 crossrefType "journal-article" @default.
• W2093306312 hasAuthorship W2093306312A5028261391 @default.
• W2093306312 hasAuthorship W2093306312A5029369714 @default.
• W2093306312 hasAuthorship W2093306312A5062739266 @default.
• W2093306312 hasAuthorship W2093306312A5066926133 @default.
• W2093306312 hasAuthorship W2093306312A5070237066 @default.
• W2093306312 hasAuthorship W2093306312A5077993878 @default.
• W2093306312 hasBestOaLocation W20933063121 @default.
• W2093306312 hasConcept C103408237 @default.
• W2093306312 hasConcept C104317684 @default.
• W2093306312 hasConcept C12554922 @default.
• W2093306312 hasConcept C143065580 @default.
• W2093306312 hasConcept C147816474 @default.
• W2093306312 hasConcept C16318435 @default.
• W2093306312 hasConcept C181199279 @default.
• W2093306312 hasConcept C2775905019 @default.
• W2093306312 hasConcept C515207424 @default.
• W2093306312 hasConcept C55493867 @default.
• W2093306312 hasConcept C86803240 @default.
• W2093306312 hasConceptScore W2093306312C103408237 @default.
• W2093306312 hasConceptScore W2093306312C104317684 @default.
• W2093306312 hasConceptScore W2093306312C12554922 @default.
• W2093306312 hasConceptScore W2093306312C143065580 @default.
• W2093306312 hasConceptScore W2093306312C147816474 @default.
• W2093306312 hasConceptScore W2093306312C16318435 @default.
• W2093306312 hasConceptScore W2093306312C181199279 @default.
• W2093306312 hasConceptScore W2093306312C2775905019 @default.
• W2093306312 hasConceptScore W2093306312C515207424 @default.
• W2093306312 hasConceptScore W2093306312C55493867 @default.
• W2093306312 hasConceptScore W2093306312C86803240 @default.
• W2093306312 hasIssue "6" @default.
• W2093306312 hasLocation W20933063121 @default.
• W2093306312 hasLocation W20933063122 @default.
• W2093306312 hasOpenAccess W2093306312 @default.
• W2093306312 hasPrimaryLocation W20933063121 @default.
• W2093306312 hasRelatedWork W1980490260 @default.
• W2093306312 hasRelatedWork W2002530597 @default.
• W2093306312 hasRelatedWork W2003936528 @default.
• W2093306312 hasRelatedWork W2040122145 @default.
• W2093306312 hasRelatedWork W2404466622 @default.
• W2093306312 hasRelatedWork W2421020410 @default.

• next