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• W2093313366 endingPage "2046" @default.
• W2093313366 startingPage "2041" @default.
• W2093313366 abstract "P-glycoprotein (P-gp) and caveolin-1alpha are both involved in membrane transport, and studies in rodent brain show that these proteins are specifically localized at the microvascular endothelium, which forms the blood-brain barrier (BBB). In humans, P-gp is also expressed in astrocytes, especially in pathological tissue. The present study examines the cellular expression of P-gp and caveolin-1alpha in fresh-frozen brain from healthy rhesus monkey using confocal microscopy and polyclonal antibodies against either P-gp or caveolin-1alpha co-labeled for astrocytes or microvascular endothelium. P-gp and caveolin-1alpha are expressed in both astrocytes and endothelium of healthy primate brain. These findings suggest that P-gp and caveolin-1alpha share a broad spectrum of cellular expression and may play a role in drug transport within the brain in addition to the BBB." @default.
• W2093313366 created "2016-06-24" @default.
• W2093313366 creator A5053445773 @default.
• W2093313366 creator A5073892880 @default.
• W2093313366 date "2003-11-01" @default.
• W2093313366 modified "2023-09-26" @default.
• W2093313366 title "P-glycoprotein and caveolin-1α in endothelium and astrocytes of primate brain" @default.
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• W2093313366 doi "https://doi.org/10.1097/00001756-200311140-00007" @default.
• W2093313366 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14600494" @default.
• W2093313366 hasPublicationYear "2003" @default.
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