Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093318267> ?p ?o ?g. }
- W2093318267 abstract "L-Canavanine is a naturally occurring L-amino acid that interferes with L-arginine-utilizing enzymes owing to its structural analogy with this L-amino acid. In macrophages and polymorphonuclear leukocytes, which express inducible nitric oxide synthase (iNOS), L-canavanine is able to prevent the L-arginine-derived synthesis of nitric oxide (NO). Its effects on constitutive NOS (cNOS) are far less clear. Because human platelets synthesize NO from L-arginine through a cNOS and because intracellular NO levels modulate platelet function, we have investigated the effects of L-canavanine on parameters potentially influenced by NO, such as platelet levels of 3',5'-cyclic guanosine monophosphate (cGMP) and responses to different aggregating agents. In our experimental conditions, L-canavanine was able to influence the response of human platelets to different aggregating agents such as catecholamines, 5-hydroxytryptamine, and ADP. Low L-canavanine concentrations (10-100 micromol/l) decreased platelet responses, whereas a high concentration (1 mmol/l) was unable to exert antiaggregating effects. In resting platelets, L-canavanine reduced the levels of cGMP, starting from a concentration of 1 mmol/l; furthermore, at the same concentrations, it was able to reduce cGMP levels at the end of the aggregation induced by collagen. In conclusion, L-canavanine exerts differential effects on human platelets in relation to the concentrations: at low levels, it exerts antiaggregating effects by actions independent of NOS inhibition, whereas, at high levels, it inhibits NO synthesis and does not exert antiaggregating effects." @default.
- W2093318267 created "2016-06-24" @default.
- W2093318267 creator A5027184698 @default.
- W2093318267 creator A5028090614 @default.
- W2093318267 creator A5041207535 @default.
- W2093318267 creator A5042697339 @default.
- W2093318267 creator A5044083918 @default.
- W2093318267 creator A5046325668 @default.
- W2093318267 creator A5072250065 @default.
- W2093318267 creator A5090558283 @default.
- W2093318267 date "1999-03-01" @default.
- W2093318267 modified "2023-09-27" @default.
- W2093318267 title "Modulation of human platelet function by l-canavanine Differential effects of low and high concentrations" @default.
- W2093318267 cites W122947453 @default.
- W2093318267 cites W1490975006 @default.
- W2093318267 cites W1590369680 @default.
- W2093318267 cites W1970530889 @default.
- W2093318267 cites W1975982125 @default.
- W2093318267 cites W1984790504 @default.
- W2093318267 cites W1994632833 @default.
- W2093318267 cites W1999873010 @default.
- W2093318267 cites W2006613925 @default.
- W2093318267 cites W2012214760 @default.
- W2093318267 cites W2020870305 @default.
- W2093318267 cites W2028639923 @default.
- W2093318267 cites W2039949381 @default.
- W2093318267 cites W2045196210 @default.
- W2093318267 cites W2048635427 @default.
- W2093318267 cites W2049100185 @default.
- W2093318267 cites W2050023150 @default.
- W2093318267 cites W2084530599 @default.
- W2093318267 cites W2084654400 @default.
- W2093318267 cites W2086641908 @default.
- W2093318267 cites W2092763906 @default.
- W2093318267 cites W2093709205 @default.
- W2093318267 cites W2095104103 @default.
- W2093318267 cites W2105821269 @default.
- W2093318267 cites W2109654316 @default.
- W2093318267 cites W2149710118 @default.
- W2093318267 cites W2403417819 @default.
- W2093318267 cites W308614014 @default.
- W2093318267 cites W2257521847 @default.
- W2093318267 doi "https://doi.org/10.1016/s0306-3623(98)00193-1" @default.
- W2093318267 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10211586" @default.
- W2093318267 hasPublicationYear "1999" @default.
- W2093318267 type Work @default.
- W2093318267 sameAs 2093318267 @default.
- W2093318267 citedByCount "10" @default.
- W2093318267 countsByYear W20933182672014 @default.
- W2093318267 crossrefType "journal-article" @default.
- W2093318267 hasAuthorship W2093318267A5027184698 @default.
- W2093318267 hasAuthorship W2093318267A5028090614 @default.
- W2093318267 hasAuthorship W2093318267A5041207535 @default.
- W2093318267 hasAuthorship W2093318267A5042697339 @default.
- W2093318267 hasAuthorship W2093318267A5044083918 @default.
- W2093318267 hasAuthorship W2093318267A5046325668 @default.
- W2093318267 hasAuthorship W2093318267A5072250065 @default.
- W2093318267 hasAuthorship W2093318267A5090558283 @default.
- W2093318267 hasConcept C126322002 @default.
- W2093318267 hasConcept C134018914 @default.
- W2093318267 hasConcept C178790620 @default.
- W2093318267 hasConcept C181199279 @default.
- W2093318267 hasConcept C185592680 @default.
- W2093318267 hasConcept C2777468819 @default.
- W2093318267 hasConcept C2777622882 @default.
- W2093318267 hasConcept C2777914855 @default.
- W2093318267 hasConcept C2780994212 @default.
- W2093318267 hasConcept C515207424 @default.
- W2093318267 hasConcept C519581460 @default.
- W2093318267 hasConcept C55493867 @default.
- W2093318267 hasConcept C71924100 @default.
- W2093318267 hasConcept C79879829 @default.
- W2093318267 hasConcept C86803240 @default.
- W2093318267 hasConcept C89560881 @default.
- W2093318267 hasConcept C98274493 @default.
- W2093318267 hasConceptScore W2093318267C126322002 @default.
- W2093318267 hasConceptScore W2093318267C134018914 @default.
- W2093318267 hasConceptScore W2093318267C178790620 @default.
- W2093318267 hasConceptScore W2093318267C181199279 @default.
- W2093318267 hasConceptScore W2093318267C185592680 @default.
- W2093318267 hasConceptScore W2093318267C2777468819 @default.
- W2093318267 hasConceptScore W2093318267C2777622882 @default.
- W2093318267 hasConceptScore W2093318267C2777914855 @default.
- W2093318267 hasConceptScore W2093318267C2780994212 @default.
- W2093318267 hasConceptScore W2093318267C515207424 @default.
- W2093318267 hasConceptScore W2093318267C519581460 @default.
- W2093318267 hasConceptScore W2093318267C55493867 @default.
- W2093318267 hasConceptScore W2093318267C71924100 @default.
- W2093318267 hasConceptScore W2093318267C79879829 @default.
- W2093318267 hasConceptScore W2093318267C86803240 @default.
- W2093318267 hasConceptScore W2093318267C89560881 @default.
- W2093318267 hasConceptScore W2093318267C98274493 @default.
- W2093318267 hasLocation W20933182671 @default.
- W2093318267 hasLocation W20933182672 @default.
- W2093318267 hasOpenAccess W2093318267 @default.
- W2093318267 hasPrimaryLocation W20933182671 @default.
- W2093318267 hasRelatedWork W1623258072 @default.
- W2093318267 hasRelatedWork W1989830998 @default.
- W2093318267 hasRelatedWork W1995909850 @default.
- W2093318267 hasRelatedWork W2000124518 @default.