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- W2093322042 abstract "It is now generally well accepted that heparin and related substances increase the fibrinolytic activity . The stimulation of the amidolytic, plasminogenolytic and fibrinogenolytic activity of tissue plasminogen activator and urinary plasminogen activator through heparin was investigated . A concentration-dependent stimulation of the plasminogenolytic and fibrinogenolytic activity of both urinary and tissue-type plasminogen activators was observed in the presence of heparin. No heparin dependence was observed in the amidolytic assay. Heparin stimulates the plasminogenolytic activity of tissue plasminogen activator in the same manner as fibrin. Both activators form complexes with heparin; the heparin-binding-site seems to be identical or related with the fibrin-binding-site of tissue plasminogen activator. The physiological role of these interactions is discussed." @default.
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- W2093322042 date "1986-06-01" @default.
- W2093322042 modified "2023-09-26" @default.
- W2093322042 title "Study on the mechanism of action of heparin and related substances on the fibrinolytic system: Relationsship between plasminogen activators and heparin" @default.
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- W2093322042 doi "https://doi.org/10.1016/0049-3848(86)90116-7" @default.
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