FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093323348> ?p ?o ?g. }

• W2093323348 endingPage "753" @default.
• W2093323348 startingPage "746" @default.
• W2093323348 abstract "Previous studies showed a renoprotective effect of l -arginine in experimental uremia. Whether this was caused by an increased nitric oxide (NO) release or depended on l -arginine per se is not clear. Here, we evaluated whether chronic administration of an NO donor, molsidomine, controlled systemic blood pressure and renal disease progression and prolonged survival in rats with renal mass reduction (RMR). Rats with RMR received the following daily in the drinking water: group 1 (n = 21), no specific therapy (vehicle); group 2 (n = 12), molsidomine, 120 mg/L; group 3 (n = 9), lisinopril, 25 mg/L; and group 4 (n = 12), reserpine, 5 mg/L, hydralazine, 80 mg/L, and hydrochlorothiazide, 25 mg/L, from day 21 after surgery, when rats had hypertension and proteinuria, until the death of the vehicle-treated rats. Molsidomine normalized systemic hypertension, only partially reduced proteinuria and serum creatinine levels, but significantly prolonged animal survival, particularly in the early stage of the disease. Lisinopril at a similar systemic blood pressure was even better than molsidomine in limiting proteinuria, preserving renal function, and prolonging survival, but triple therapy, despite being effective on blood pressure, offered no renoprotection or prolonged survival. Endothelin-1 (ET-1) levels, formed in excessive amounts by the kidneys of these animals, were reduced by molsidomine and lisinopril, but not by triple therapy. The prolongation of survival by NO donor could be attributed to its effect of reducing ET levels, which in turn may limit the smooth muscle cell proliferation and matrix accumulation responsible for organ and, especially, myocardial fibrosis in uremia." @default.
• W2093323348 created "2016-06-24" @default.
• W2093323348 creator A5001678867 @default.
• W2093323348 creator A5019429551 @default.
• W2093323348 creator A5023556434 @default.
• W2093323348 creator A5031960025 @default.
• W2093323348 creator A5035442609 @default.
• W2093323348 creator A5046398268 @default.
• W2093323348 creator A5064460654 @default.
• W2093323348 creator A5090115261 @default.
• W2093323348 date "1999-04-01" @default.
• W2093323348 modified "2023-10-06" @default.
• W2093323348 title "Renoprotection by nitric oxide donor and lisinopril in the remnant kidney model" @default.
• W2093323348 cites W1909254787 @default.
• W2093323348 cites W1964920299 @default.
• W2093323348 cites W1968002068 @default.
• W2093323348 cites W1975755598 @default.
• W2093323348 cites W1976502176 @default.
• W2093323348 cites W1979646999 @default.
• W2093323348 cites W1997180556 @default.
• W2093323348 cites W2002367577 @default.
• W2093323348 cites W2003423004 @default.
• W2093323348 cites W2009851966 @default.
• W2093323348 cites W2012497346 @default.
• W2093323348 cites W2030383062 @default.
• W2093323348 cites W2031534703 @default.
• W2093323348 cites W2053282831 @default.
• W2093323348 cites W2055296168 @default.
• W2093323348 cites W2058539576 @default.
• W2093323348 cites W2063928700 @default.
• W2093323348 cites W2084138782 @default.
• W2093323348 cites W2114011268 @default.
• W2093323348 cites W2136898798 @default.
• W2093323348 cites W2145792977 @default.
• W2093323348 cites W2158398528 @default.
• W2093323348 cites W2262420475 @default.
• W2093323348 cites W3156148333 @default.
• W2093323348 doi "https://doi.org/10.1016/s0272-6386(99)70229-5" @default.
• W2093323348 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10196019" @default.
• W2093323348 hasPublicationYear "1999" @default.
• W2093323348 type Work @default.
• W2093323348 sameAs 2093323348 @default.
• W2093323348 citedByCount "40" @default.
• W2093323348 countsByYear W20933233482012 @default.
• W2093323348 countsByYear W20933233482013 @default.
• W2093323348 countsByYear W20933233482016 @default.
• W2093323348 countsByYear W20933233482017 @default.
• W2093323348 countsByYear W20933233482021 @default.
• W2093323348 countsByYear W20933233482023 @default.
• W2093323348 crossrefType "journal-article" @default.
• W2093323348 hasAuthorship W2093323348A5001678867 @default.
• W2093323348 hasAuthorship W2093323348A5019429551 @default.
• W2093323348 hasAuthorship W2093323348A5023556434 @default.
• W2093323348 hasAuthorship W2093323348A5031960025 @default.
• W2093323348 hasAuthorship W2093323348A5035442609 @default.
• W2093323348 hasAuthorship W2093323348A5046398268 @default.
• W2093323348 hasAuthorship W2093323348A5064460654 @default.
• W2093323348 hasAuthorship W2093323348A5090115261 @default.
• W2093323348 hasConcept C126322002 @default.
• W2093323348 hasConcept C126894567 @default.
• W2093323348 hasConcept C134018914 @default.
• W2093323348 hasConcept C159641895 @default.
• W2093323348 hasConcept C27016395 @default.
• W2093323348 hasConcept C2776635150 @default.
• W2093323348 hasConcept C2777880890 @default.
• W2093323348 hasConcept C2778176769 @default.
• W2093323348 hasConcept C2779561371 @default.
• W2093323348 hasConcept C2780091579 @default.
• W2093323348 hasConcept C2780306776 @default.
• W2093323348 hasConcept C2780521442 @default.
• W2093323348 hasConcept C2780773033 @default.
• W2093323348 hasConcept C519581460 @default.
• W2093323348 hasConcept C71924100 @default.
• W2093323348 hasConcept C84393581 @default.
• W2093323348 hasConcept C98274493 @default.
• W2093323348 hasConceptScore W2093323348C126322002 @default.
• W2093323348 hasConceptScore W2093323348C126894567 @default.
• W2093323348 hasConceptScore W2093323348C134018914 @default.
• W2093323348 hasConceptScore W2093323348C159641895 @default.
• W2093323348 hasConceptScore W2093323348C27016395 @default.
• W2093323348 hasConceptScore W2093323348C2776635150 @default.
• W2093323348 hasConceptScore W2093323348C2777880890 @default.
• W2093323348 hasConceptScore W2093323348C2778176769 @default.
• W2093323348 hasConceptScore W2093323348C2779561371 @default.
• W2093323348 hasConceptScore W2093323348C2780091579 @default.
• W2093323348 hasConceptScore W2093323348C2780306776 @default.
• W2093323348 hasConceptScore W2093323348C2780521442 @default.
• W2093323348 hasConceptScore W2093323348C2780773033 @default.
• W2093323348 hasConceptScore W2093323348C519581460 @default.
• W2093323348 hasConceptScore W2093323348C71924100 @default.
• W2093323348 hasConceptScore W2093323348C84393581 @default.
• W2093323348 hasConceptScore W2093323348C98274493 @default.
• W2093323348 hasIssue "4" @default.
• W2093323348 hasLocation W20933233481 @default.
• W2093323348 hasLocation W20933233482 @default.
• W2093323348 hasOpenAccess W2093323348 @default.
• W2093323348 hasPrimaryLocation W20933233481 @default.
• W2093323348 hasRelatedWork W2347730591 @default.

• next