FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093330600> ?p ?o ?g. }

• W2093330600 endingPage "596" @default.
• W2093330600 startingPage "587" @default.
• W2093330600 abstract "In this study, interferon gamma (IFN-γ) and interferon gamma receptor (IFN-γR) genes have been identified in non-avian reptile, the North American green anole lizard (Anolis carolinensis). Like their counterparts from other jawed vertebrates, lizard IFN-γ, IFN-γR1 and IFN-γR2 show conserved features in genomic organizations, gene loci and protein sequences. The IFN-γ gene has the full cDNA sequence of 936 bp, with 522 bp open reading frame (ORF) encoding 174 amino acids, and has the genomic organization of four exons and three introns as observed in IFN-γ genes of other classes of vertebrates. The receptors, IFN-γR1 and IFN-γR2 have the ORF of 1278 and 984 bp, coding for 425 and 327 aa, respectively, with the genome organization of seven exons and six introns. In the gene loci of IFN-γ, DYRK2, IL22, IL26 and MDM1 are found with conserved synteny in vertebrates, and similar genes adjacent to IFN-γR1 and IFN-γR2 were also found. These receptors also contain conserved motifs, such as the membrane-proximal region and the C-terminal five residue motif in IFN-γR1, and intracellular conservative sequence in IFN-γR2, which have been confirmed to mediate down-stream JAK-STAT signaling pathway in mammals. IFN-γ and its receptors, IFN-γR1 and IFN-γR2 were constitutively expressed in organs/tissues examined in the lizard, and up-regulated expression of IFN-γ was observed in organs/tissues examined following the poly(I:C) stimulation, suggesting its antiviral role in lizards. The conserved features of IFN-γ and its receptors, IFN-γR1 and IFN-γR2, in gene organization and gene locus as well as in functional domain or motif may imply that the function of type II IFN system is evolutionarily conserved in the green anole lizard, as observed in other classes of vertebrates." @default.
• W2093330600 created "2016-06-24" @default.
• W2093330600 creator A5013973657 @default.
• W2093330600 creator A5015105154 @default.
• W2093330600 creator A5026270755 @default.
• W2093330600 creator A5044023031 @default.
• W2093330600 creator A5051875515 @default.
• W2093330600 creator A5053984606 @default.
• W2093330600 creator A5068589196 @default.
• W2093330600 creator A5077842755 @default.
• W2093330600 date "2013-12-01" @default.
• W2093330600 modified "2023-10-13" @default.
• W2093330600 title "IFN-γ and its receptors in a reptile reveal the evolutionary conservation of type II IFNs in vertebrates" @default.
• W2093330600 cites W135486017 @default.
• W2093330600 cites W1530235393 @default.
• W2093330600 cites W1592356588 @default.
• W2093330600 cites W1606957656 @default.
• W2093330600 cites W1640445122 @default.
• W2093330600 cites W1805810149 @default.
• W2093330600 cites W1869207333 @default.
• W2093330600 cites W1963930418 @default.
• W2093330600 cites W1972073034 @default.
• W2093330600 cites W1973405995 @default.
• W2093330600 cites W1977608747 @default.
• W2093330600 cites W1982516668 @default.
• W2093330600 cites W1987009823 @default.
• W2093330600 cites W1987056502 @default.
• W2093330600 cites W1992396801 @default.
• W2093330600 cites W1992471058 @default.
• W2093330600 cites W1993550371 @default.
• W2093330600 cites W1999095956 @default.
• W2093330600 cites W2009331888 @default.
• W2093330600 cites W2011184409 @default.
• W2093330600 cites W2020173029 @default.
• W2093330600 cites W2026691407 @default.
• W2093330600 cites W2029303000 @default.
• W2093330600 cites W2046175585 @default.
• W2093330600 cites W2046634649 @default.
• W2093330600 cites W2068925537 @default.
• W2093330600 cites W2082889122 @default.
• W2093330600 cites W2082977625 @default.
• W2093330600 cites W2085237060 @default.
• W2093330600 cites W2085688822 @default.
• W2093330600 cites W2095540469 @default.
• W2093330600 cites W2097382368 @default.
• W2093330600 cites W2099323895 @default.
• W2093330600 cites W2125121305 @default.
• W2093330600 cites W2134768631 @default.
• W2093330600 cites W2137979020 @default.
• W2093330600 cites W2139453209 @default.
• W2093330600 cites W2153398168 @default.
• W2093330600 cites W2155577276 @default.
• W2093330600 cites W2155873802 @default.
• W2093330600 cites W2157135427 @default.
• W2093330600 cites W2167017590 @default.
• W2093330600 cites W2305187521 @default.
• W2093330600 cites W52751992 @default.
• W2093330600 doi "https://doi.org/10.1016/j.dci.2013.07.002" @default.
• W2093330600 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23850722" @default.
• W2093330600 hasPublicationYear "2013" @default.
• W2093330600 type Work @default.
• W2093330600 sameAs 2093330600 @default.
• W2093330600 citedByCount "25" @default.
• W2093330600 countsByYear W20933306002014 @default.
• W2093330600 countsByYear W20933306002016 @default.
• W2093330600 countsByYear W20933306002017 @default.
• W2093330600 countsByYear W20933306002018 @default.
• W2093330600 countsByYear W20933306002019 @default.
• W2093330600 countsByYear W20933306002020 @default.
• W2093330600 countsByYear W20933306002021 @default.
• W2093330600 countsByYear W20933306002022 @default.
• W2093330600 countsByYear W20933306002023 @default.
• W2093330600 crossrefType "journal-article" @default.
• W2093330600 hasAuthorship W2093330600A5013973657 @default.
• W2093330600 hasAuthorship W2093330600A5015105154 @default.
• W2093330600 hasAuthorship W2093330600A5026270755 @default.
• W2093330600 hasAuthorship W2093330600A5044023031 @default.
• W2093330600 hasAuthorship W2093330600A5051875515 @default.
• W2093330600 hasAuthorship W2093330600A5053984606 @default.
• W2093330600 hasAuthorship W2093330600A5068589196 @default.
• W2093330600 hasAuthorship W2093330600A5077842755 @default.
• W2093330600 hasConcept C104317684 @default.
• W2093330600 hasConcept C141231307 @default.
• W2093330600 hasConcept C153911025 @default.
• W2093330600 hasConcept C167625842 @default.
• W2093330600 hasConcept C170493617 @default.
• W2093330600 hasConcept C187882448 @default.
• W2093330600 hasConcept C199216141 @default.
• W2093330600 hasConcept C22322919 @default.
• W2093330600 hasConcept C2776178377 @default.
• W2093330600 hasConcept C36823959 @default.
• W2093330600 hasConcept C47289529 @default.
• W2093330600 hasConcept C53702515 @default.
• W2093330600 hasConcept C54355233 @default.
• W2093330600 hasConcept C86803240 @default.
• W2093330600 hasConcept C94671646 @default.
• W2093330600 hasConceptScore W2093330600C104317684 @default.
• W2093330600 hasConceptScore W2093330600C141231307 @default.

• next