FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093341978> ?p ?o ?g. }

• W2093341978 endingPage "370" @default.
• W2093341978 startingPage "359" @default.
• W2093341978 abstract "ABSTRACT The effects of sublethal concentrations of four different classes of translation inhibitors (puromycin, tetracycline, chloramphenicol, and erythromycin) on global transcription patterns of Streptococcus pneumoniae R6 were determined by microarray analyses. Consistent with the general mode of action of these inhibitors, relative transcript levels of genes that encode ribosomal proteins and translation factors or that mediate tRNA charging and amino acid biosynthesis increased or decreased, respectively. Transcription of the heat shock regulon was induced only by puromycin or streptomycin treatment, which lead to truncation or mistranslation, respectively, but not by other antibiotics that block translation, transcription, or amino acid charging of tRNA. In contrast, relative transcript amounts of certain genes involved in transport, cellular processes, energy metabolism, and purine nucleotide ( pur ) biosynthesis were changed by different translation inhibitors. In particular, transcript amounts from a pur gene cluster and from purine uptake and salvage genes were significantly elevated by several translation inhibitors, but not by antibiotics that target other cellular processes. Northern blotting confirmed increased transcript amounts from part of the pur gene cluster in cells challenged by translation inhibitors and revealed the presence of a 10-kb transcript. Purine metabolism genes were negatively regulated by a homologue of the PurR regulatory protein, and full derepression in a Δ purR mutant depended on optimal translation. Unexpectedly, hierarchical clustering of the microarray data distinguished among the global transcription patterns caused by antibiotics that inhibit different steps in the translation cycle. Together, these results show that there is extensive control of transcript amounts by translation in S. pneumoniae , especially for de novo purine nucleotide biosynthesis. In addition, these global transcription patterns form a signature that can be used to classify the mode of action and potential mechanism of new translation inhibitors." @default.
• W2093341978 created "2016-06-24" @default.
• W2093341978 creator A5002284017 @default.
• W2093341978 creator A5006090738 @default.
• W2093341978 creator A5037036496 @default.
• W2093341978 creator A5066677972 @default.
• W2093341978 creator A5074883959 @default.
• W2093341978 date "2003-01-01" @default.
• W2093341978 modified "2023-10-10" @default.
• W2093341978 title "Transcriptional Regulation and Signature Patterns Revealed by Microarray Analyses of <i>Streptococcus pneumoniae</i> R6 Challenged with Sublethal Concentrations of Translation Inhibitors" @default.
• W2093341978 cites W1464148333 @default.
• W2093341978 cites W1488068148 @default.
• W2093341978 cites W1509839194 @default.
• W2093341978 cites W1531734692 @default.
• W2093341978 cites W1536921551 @default.
• W2093341978 cites W1549714335 @default.
• W2093341978 cites W1567903209 @default.
• W2093341978 cites W1587266897 @default.
• W2093341978 cites W1631363513 @default.
• W2093341978 cites W1718026184 @default.
• W2093341978 cites W1730326818 @default.
• W2093341978 cites W1845778411 @default.
• W2093341978 cites W1857497956 @default.
• W2093341978 cites W1942028630 @default.
• W2093341978 cites W1952817825 @default.
• W2093341978 cites W1967386006 @default.
• W2093341978 cites W1978861899 @default.
• W2093341978 cites W1979431512 @default.
• W2093341978 cites W2000352879 @default.
• W2093341978 cites W2015745987 @default.
• W2093341978 cites W2019234222 @default.
• W2093341978 cites W2027046035 @default.
• W2093341978 cites W2034411310 @default.
• W2093341978 cites W2051633068 @default.
• W2093341978 cites W2062828655 @default.
• W2093341978 cites W2062985204 @default.
• W2093341978 cites W2065762927 @default.
• W2093341978 cites W2068372433 @default.
• W2093341978 cites W2069566476 @default.
• W2093341978 cites W2072802762 @default.
• W2093341978 cites W2073359935 @default.
• W2093341978 cites W2082459658 @default.
• W2093341978 cites W2097654784 @default.
• W2093341978 cites W2098883789 @default.
• W2093341978 cites W2101291953 @default.
• W2093341978 cites W2112024645 @default.
• W2093341978 cites W2116777154 @default.
• W2093341978 cites W2124433456 @default.
• W2093341978 cites W2131994307 @default.
• W2093341978 cites W2143273383 @default.
• W2093341978 cites W2145573096 @default.
• W2093341978 cites W2150084583 @default.
• W2093341978 cites W2150926065 @default.
• W2093341978 cites W2156051592 @default.
• W2093341978 cites W2165413657 @default.
• W2093341978 cites W2166117980 @default.
• W2093341978 cites W2170243611 @default.
• W2093341978 cites W2171846964 @default.
• W2093341978 cites W4240971294 @default.
• W2093341978 cites W751857752 @default.
• W2093341978 doi "https://doi.org/10.1128/jb.185.1.359-370.2003" @default.
• W2093341978 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/141824" @default.
• W2093341978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12486074" @default.
• W2093341978 hasPublicationYear "2003" @default.
• W2093341978 type Work @default.
• W2093341978 sameAs 2093341978 @default.
• W2093341978 citedByCount "123" @default.
• W2093341978 countsByYear W20933419782012 @default.
• W2093341978 countsByYear W20933419782013 @default.
• W2093341978 countsByYear W20933419782014 @default.
• W2093341978 countsByYear W20933419782016 @default.
• W2093341978 countsByYear W20933419782017 @default.
• W2093341978 countsByYear W20933419782018 @default.
• W2093341978 countsByYear W20933419782019 @default.
• W2093341978 countsByYear W20933419782020 @default.
• W2093341978 countsByYear W20933419782021 @default.
• W2093341978 countsByYear W20933419782022 @default.
• W2093341978 countsByYear W20933419782023 @default.
• W2093341978 crossrefType "journal-article" @default.
• W2093341978 hasAuthorship W2093341978A5002284017 @default.
• W2093341978 hasAuthorship W2093341978A5006090738 @default.
• W2093341978 hasAuthorship W2093341978A5037036496 @default.
• W2093341978 hasAuthorship W2093341978A5066677972 @default.
• W2093341978 hasAuthorship W2093341978A5074883959 @default.
• W2093341978 hasBestOaLocation W20933419782 @default.
• W2093341978 hasConcept C104317684 @default.
• W2093341978 hasConcept C105580179 @default.
• W2093341978 hasConcept C138885662 @default.
• W2093341978 hasConcept C149364088 @default.
• W2093341978 hasConcept C153911025 @default.
• W2093341978 hasConcept C165864922 @default.
• W2093341978 hasConcept C179926584 @default.
• W2093341978 hasConcept C2779200571 @default.
• W2093341978 hasConcept C3675279 @default.
• W2093341978 hasConcept C41895202 @default.
• W2093341978 hasConcept C55493867 @default.
• W2093341978 hasConcept C62361671 @default.
• W2093341978 hasConcept C67705224 @default.

• next