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• W2093344091 abstract "Background Previous animal studies and a pilot clinical trial demonstrated that submucosal injection of a thiol compound called mesna could chemically soften connective tissues and thus facilitate endoscopic submucosal dissection (ESD). Objective To evaluate whether mesna injection could reduce procedural times for gastric ESD. Design Double-blind, block-randomized, controlled trial. Setting University hospital. Patients A total of 101 patients with superficial gastric cancer indicated for ESD were enrolled and randomly assigned to either the mesna or control (saline solution) group. Intervention Traditional ESD was performed with a single bolus injection of mesna or saline solution. Main Outcome Measurements Time for submucosal dissection (TSD). Results En bloc resection was achieved for all lesions in the mesna group (53/53) and 51 of 52 lesions (98.08%) in the control group. TSD was not statistically different between the groups (18.62 ± 13.9 [mean ± SD] minutes for the mesna group and 24.58 ± 24.55 [mean ± SD] minutes for the control group; P = .128), and there were fewer time-consuming cases (times over 30 minutes) in the mesna group compared with controls (7/53 vs 15/52; P = .049). Multivariate regression analysis demonstrated that use of mesna, specimen size, and the presence of fibrous scars were significantly correlated with TSD (P < .05). Limitations Single-center study. Conclusion TSD was not significantly different between the mesna and control injection groups, but multivariate analysis indicated that mesna injection reduced procedural challenges associated with the submucosal dissection. (Clinical trial registration number: UMIN000003786.) Previous animal studies and a pilot clinical trial demonstrated that submucosal injection of a thiol compound called mesna could chemically soften connective tissues and thus facilitate endoscopic submucosal dissection (ESD). To evaluate whether mesna injection could reduce procedural times for gastric ESD. Double-blind, block-randomized, controlled trial. University hospital. A total of 101 patients with superficial gastric cancer indicated for ESD were enrolled and randomly assigned to either the mesna or control (saline solution) group. Traditional ESD was performed with a single bolus injection of mesna or saline solution. Time for submucosal dissection (TSD). En bloc resection was achieved for all lesions in the mesna group (53/53) and 51 of 52 lesions (98.08%) in the control group. TSD was not statistically different between the groups (18.62 ± 13.9 [mean ± SD] minutes for the mesna group and 24.58 ± 24.55 [mean ± SD] minutes for the control group; P = .128), and there were fewer time-consuming cases (times over 30 minutes) in the mesna group compared with controls (7/53 vs 15/52; P = .049). Multivariate regression analysis demonstrated that use of mesna, specimen size, and the presence of fibrous scars were significantly correlated with TSD (P < .05). Single-center study. TSD was not significantly different between the mesna and control injection groups, but multivariate analysis indicated that mesna injection reduced procedural challenges associated with the submucosal dissection. (Clinical trial registration number: UMIN000003786.)" @default.
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• W2093344091 date "2014-05-01" @default.
• W2093344091 modified "2023-10-16" @default.
• W2093344091 title "A double-blind, block-randomized, placebo-controlled trial to identify the chemical assistance effect of mesna submucosal injection for gastric endoscopic submucosal dissection" @default.
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• W2093344091 doi "https://doi.org/10.1016/j.gie.2013.09.027" @default.
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