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• W2093345230 abstract "Intraperitoneal injection of Group A streptococcal cell wall (SCW) fragments into female Lewis rats results in the induction of an acute hepatic inflammation that progresses to granulomatous lesions. Kupffer cells have been shown to rapidly clear circulating SCW which triggers production of TGF-β. In this study, we examined Kupffer cells for the expression of TGF-β receptors to determine if these cells might be modulated in an autocrine/paracrine fashion by TGF-β during SCW-hepatic inflammation. By receptor crosslinking and subsequent SDS-PAGE analysis we demonstrate that Kupffer cells express Type I TGF-β receptors, but not Types II and III. Scatchard analysis indicated a receptor density of approximately 1100 receptors per cell. Functionally, TGF-β was found to be chemotactic for Kupffer cells in vitro and this chemotactic response was higher in cells isolated from rats 1–21 days post SCW-injection. Although TGF-β1 mRNA is constitutively expressed by Kupffer cells, in vitro stimulation of the cultures with purified TGF-β augments the expression of TGF-β1 mRNA and protein synthesis suggesting autocrine/paracrine regulation. These results indicate that TGFβ secreted by Kupffer cells during SCW-induced hepatic inflammation may amplify its own expression and regulate Kupffer cell functions relevant to the formation of granulomatous lesions within the liver." @default.
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• W2093345230 date "1992-01-01" @default.
• W2093345230 modified "2023-09-27" @default.
• W2093345230 title "Kupffer Cells Express Type I TGF-<i>β</i>Receptors, Migrate to TGF-<i>β</i>and Participate in Streptococcal Cell Wall Induced Hepatic Granuloma Formation" @default.
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• W2093345230 doi "https://doi.org/10.3109/08977199209023939" @default.
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