Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093351570> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2093351570 endingPage "379" @default.
- W2093351570 startingPage "373" @default.
- W2093351570 abstract "The aim of this study was to test the hypothesis that the most appropriate model for studying the diffusional release of an active from a topical formulation is one in which the membrane offers minimal resistance to release and involves a receptor phase that presents the least possible interfacial discontinuity. Using ketoprofen as the active, a series of simple gels were prepared consisting of PEG400 thickened with Cabosil M5. Using Franz-type diffusion cells, three different types of membrane (two porous and one non-porous) were compared, as were receptor phases of PEG400 (component of formulation) and PBS. Of the membranes tested only 0.2 microm nylon provided consistent first order kinetics for a range of gel consistencies, indicating negligible influence of the membrane. The non-porous silicone membrane did not show first order kinetic profile confirming the diffusional nature of such a membrane. From the non-thickened formulations, diffusional release into a receptor phase of PEG400 was some 3x that into PBS, whereas from the formulation thickened with 5% Cabosil M5, diffusional release into a receptor phase of PEG400 was 6x lower than that into PBS. Diffusional release into PBS did not follow first order kinetics while diffusion into PEG400 did, suggesting that the existence of a discontinuity affected the release process. Although the importance of zero-resistance membranes is of perhaps obvious importance, it is often not stated in the literature. The existence of phase/hydrodynamic boundaries in release studies can be a source of significant inaccuracy." @default.
- W2093351570 created "2016-06-24" @default.
- W2093351570 creator A5043392671 @default.
- W2093351570 creator A5051812452 @default.
- W2093351570 creator A5053890371 @default.
- W2093351570 creator A5089221213 @default.
- W2093351570 date "2003-07-01" @default.
- W2093351570 modified "2023-09-23" @default.
- W2093351570 title "Effects of Membrane Type and Liquid/Liquid Phase Boundary onIn VitroRelease of Ketoprofen from Gel Formulations" @default.
- W2093351570 cites W1560080685 @default.
- W2093351570 cites W1974572598 @default.
- W2093351570 cites W1978044603 @default.
- W2093351570 cites W1988879401 @default.
- W2093351570 cites W2007868120 @default.
- W2093351570 cites W2044963988 @default.
- W2093351570 cites W2045744234 @default.
- W2093351570 cites W2067203803 @default.
- W2093351570 cites W2079493003 @default.
- W2093351570 cites W2085788809 @default.
- W2093351570 cites W2092673197 @default.
- W2093351570 cites W2094482796 @default.
- W2093351570 cites W2102467849 @default.
- W2093351570 doi "https://doi.org/10.1080/10611860310001636890" @default.
- W2093351570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14668058" @default.
- W2093351570 hasPublicationYear "2003" @default.
- W2093351570 type Work @default.
- W2093351570 sameAs 2093351570 @default.
- W2093351570 citedByCount "21" @default.
- W2093351570 countsByYear W20933515702012 @default.
- W2093351570 countsByYear W20933515702014 @default.
- W2093351570 countsByYear W20933515702016 @default.
- W2093351570 countsByYear W20933515702020 @default.
- W2093351570 countsByYear W20933515702021 @default.
- W2093351570 countsByYear W20933515702022 @default.
- W2093351570 crossrefType "journal-article" @default.
- W2093351570 hasAuthorship W2093351570A5043392671 @default.
- W2093351570 hasAuthorship W2093351570A5051812452 @default.
- W2093351570 hasAuthorship W2093351570A5053890371 @default.
- W2093351570 hasAuthorship W2093351570A5089221213 @default.
- W2093351570 hasConcept C121332964 @default.
- W2093351570 hasConcept C127413603 @default.
- W2093351570 hasConcept C148898269 @default.
- W2093351570 hasConcept C178790620 @default.
- W2093351570 hasConcept C185592680 @default.
- W2093351570 hasConcept C192562407 @default.
- W2093351570 hasConcept C2780744026 @default.
- W2093351570 hasConcept C41625074 @default.
- W2093351570 hasConcept C42360764 @default.
- W2093351570 hasConcept C43617362 @default.
- W2093351570 hasConcept C44280652 @default.
- W2093351570 hasConcept C55493867 @default.
- W2093351570 hasConcept C62520636 @default.
- W2093351570 hasConcept C69357855 @default.
- W2093351570 hasConcept C77281830 @default.
- W2093351570 hasConcept C97355855 @default.
- W2093351570 hasConceptScore W2093351570C121332964 @default.
- W2093351570 hasConceptScore W2093351570C127413603 @default.
- W2093351570 hasConceptScore W2093351570C148898269 @default.
- W2093351570 hasConceptScore W2093351570C178790620 @default.
- W2093351570 hasConceptScore W2093351570C185592680 @default.
- W2093351570 hasConceptScore W2093351570C192562407 @default.
- W2093351570 hasConceptScore W2093351570C2780744026 @default.
- W2093351570 hasConceptScore W2093351570C41625074 @default.
- W2093351570 hasConceptScore W2093351570C42360764 @default.
- W2093351570 hasConceptScore W2093351570C43617362 @default.
- W2093351570 hasConceptScore W2093351570C44280652 @default.
- W2093351570 hasConceptScore W2093351570C55493867 @default.
- W2093351570 hasConceptScore W2093351570C62520636 @default.
- W2093351570 hasConceptScore W2093351570C69357855 @default.
- W2093351570 hasConceptScore W2093351570C77281830 @default.
- W2093351570 hasConceptScore W2093351570C97355855 @default.
- W2093351570 hasIssue "6" @default.
- W2093351570 hasLocation W20933515701 @default.
- W2093351570 hasLocation W20933515702 @default.
- W2093351570 hasOpenAccess W2093351570 @default.
- W2093351570 hasPrimaryLocation W20933515701 @default.
- W2093351570 hasRelatedWork W1968937971 @default.
- W2093351570 hasRelatedWork W1986088386 @default.
- W2093351570 hasRelatedWork W1996151977 @default.
- W2093351570 hasRelatedWork W2024637950 @default.
- W2093351570 hasRelatedWork W2026319122 @default.
- W2093351570 hasRelatedWork W2029598880 @default.
- W2093351570 hasRelatedWork W2045005718 @default.
- W2093351570 hasRelatedWork W2122723826 @default.
- W2093351570 hasRelatedWork W2748952813 @default.
- W2093351570 hasRelatedWork W2899084033 @default.
- W2093351570 hasVolume "11" @default.
- W2093351570 isParatext "false" @default.
- W2093351570 isRetracted "false" @default.
- W2093351570 magId "2093351570" @default.
- W2093351570 workType "article" @default.