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• W2093354456 abstract "BDNF and its gene polymorphism may be important in synaptic plasticity and neuron survival and may become a key target in the physiopathology of long-term heroin use. Thus, we investigated the relationships between brain-derived neurotrophic factor (BDNF) plasma concentrations and the BDNF Val66Met nucleotide polymorphism (SNP) in heroin-dependent patients. The pretreatment expression levels of plasma BDNF and the BDNF Val66Met SNP in 172 heroin-dependent patients and 102 healthy controls were checked. BDNF levels were significantly lower in patients (F = 52.28, p < 0.0001), but the distribution of the SNP was not significantly different. Nor were plasma BDNF levels significantly different between Met/Met, Met/Val and Val/Val carriers in each group, which indicated that the BDNF Val66Met SNP did not affect plasma BDNF levels in our participants. In heroin-dependent patients, plasma BDNF levels were negatively correlated with the length of heroin dependency. Long-term (>15 years) users had significantly lower plasma BDNF levels than did short-term (<5 years) users. We conclude that plasma BDNF concentration in habitual heroin users are not affected by BDNF Val66Met gene variants, but by the length of the heroin dependency." @default.
• W2093354456 created "2016-06-24" @default.
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• W2093354456 date "2015-02-02" @default.
• W2093354456 modified "2023-10-18" @default.
• W2093354456 title "The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese heroin-dependent patients" @default.
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• W2093354456 doi "https://doi.org/10.1038/srep08148" @default.
• W2093354456 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4313085" @default.
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