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- W2093359404 abstract "A durable amnesia for an inhibitory avoidance response was induced in mice by an immediate posttraining injection of the protein-synthesis inhibitor anisomycin. Different groups were injected, immediately after training or 30 min prior to testing, with various doses of d-amphetamine in an attempt to alleviate the amnesia. Results indicated that, while immediate posttraining treatments were ineffective, substantial recovery of memory occurred when d-amphetamine (.5, 1.0, and 2.0 mg/kg) was administered before testing. Additional experiments showed: (1) that amphetamine-induced facilitation of avoidance was specific for the situation in which training occurred and thus could not be attributed to nonspecific effects of acute amphetamine treatment and (2) that enhanced avoidance could not be produced by pentylenetetrazol, strychnine, or noncontingent footshock. Amnesia could also be reversed by pretest treatment with methylphenidate (15 and 20 mg/kg). Administration of the amphetamine analog 4-hydroxyamphetamine, which principally releases peripheral catecholamines, failed to reverse the amnesia. These findings add to the growing body of evidence that suggests that catecholamines are involved in memory retrieval processes." @default.
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- W2093359404 date "1982-09-01" @default.
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- W2093359404 title "Facilitation of retrieval by d-amphetamine following anisomycin-induced amnesia" @default.
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- W2093359404 doi "https://doi.org/10.3758/bf03332952" @default.
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