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- W2093359863 abstract "L’anidulafungine est une nouvelle échinocandine aux propriétés antifongiques démontrées in vitro et in vivo contre Candida sp. et Aspergillus sp. L’anidulafungine est fongicide contre Candida sp., y compris ceux résistants aux azolés et à l’amphotéricine B, et fongistatique contre Aspergillus sp. Son volume de distribution à l’équilibre est estimé entre 30 et 50 litres, largement supérieur à celui des autres échinocandines. Sa demi-vie d’élimination étant prolongée d’environ 24 heures, une seule dose quotidienne — par voie intraveineuse — suffit à couvrir le nycthémère. La concentration à l’état d’équilibre est atteinte rapidement après une dose de charge du double de la dose thérapeutique. Contrairement aux autres échinocandines, l’anidulafungine n’est pas métabolisée par le foie ni éliminée par le rein ; elle n’a pas d’effet sur le cytochrome P450 hépatique. Sa posologie n’a besoin d’aucune adaptation chez l’insuffisant hépatique et l’insuffisant rénal. On ne lui connaît pas d’interaction médicamenteuse, ce qui renforce sa maniabilité. En particulier l’anidulafungine ne présente pas d’interaction avec la ciclosporine ni avec le tacrolimus, ce qui présente un grand intérêt chez les patients transplantés. L’anidulafungine est donc, de par ses propriétés pharmacologiques, une option thérapeutique intéressante pour le traitement d’une grande variété d’infections fongiques invasives. Anidulafungin is a new echinocandin with in vitro and in vivo antifungal activity demonstrated against Candida and Aspergillus spp. Anidulafungin is fungicidal against Candida spp., including azole-resistant and amphotericin B-resistant species, and fungistatic against Aspergillus spp. Its volume of distribution is approximately 30-50 L, much higher than other echinocandins. With an elimination half-life of approximately 24 h, once daily administration – intravenously – is enough to cover nycterohemer. Steady state concentration is rapidly achieved following a single loading dose of double the maintenance dose. In contrast to other echinocandins, anidulafungin is not metabolized by the liver and not cleared renally, and has no impact on hepatic cytochrome P450. It does not need adjustment for hepatic or renal insufficiency. No drug-drug interaction has been described with anidulafungin. In particular, anidulafungin has no interaction with cyclosporine and tacrolimus, which is highly desirable in transplant recipients. Owing to its pharmacologic properties, anidulafungin is an interesting therapeutic option for a wide range of invasive fungal infections." @default.
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- W2093359863 date "2007-12-01" @default.
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- W2093359863 title "Propriétés pharmacocinétiques et pharmacodynamiques de l’anidulafungine" @default.
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- W2093359863 doi "https://doi.org/10.1016/s1624-0693(07)78764-9" @default.
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