FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093367519> ?p ?o ?g. }

• W2093367519 endingPage "194" @default.
• W2093367519 startingPage "182" @default.
• W2093367519 abstract "Our objective is to identify molecular factors which contribute to the increased risk of smokers for oral squamous cell carcinoma (OSCC). In the present study, we investigated the effects of cigarette smoke condensate (CSC) on gene expression profiles in different human oral cell phenotypes: normal epidermal keratinocytes (NHEK), oral dysplasia cell lines (Leuk1 and Leuk2), and a primary oral carcinoma cell line (101A). We determined differential gene expression patterns in CSC-exposed versus non-exposed cells using high-density microarray RNA expression profiling and validation by quantitative real-time RT-PCR. A set of 35 genes was specifically up- or down-regulated following CSC treatment (25microg/ml for 24h) by at least 2-fold in any one cell type. Notably, five genes of the cytochrome P450 (CYP1A1, CYP1B1) and aldo-keto reductase (AKR1C1, AKR1C3, AKR1B10) families were highly increased in expression, some of them 15- to 30-fold. The timing and extent of induction for these genes differed among the four cell phenotypes. A potential biological interaction network for the CSC response in oral cells was derived from these data, proposing novel putative response pathways. These CSC-responsive genes presumably participate in the prevention or repair of carcinogen-induced DNA damage in tobacco-related oral carcinogenesis, and may potentially be exploited for determining the severity of exposure and for correcting mutagenic damage in exposed tissues of the oral cavity." @default.
• W2093367519 created "2016-06-24" @default.
• W2093367519 creator A5000392815 @default.
• W2093367519 creator A5046937172 @default.
• W2093367519 creator A5057642803 @default.
• W2093367519 creator A5066992396 @default.
• W2093367519 creator A5077562768 @default.
• W2093367519 creator A5087581002 @default.
• W2093367519 date "2006-08-01" @default.
• W2093367519 modified "2023-09-26" @default.
• W2093367519 title "Cigarette smoke condensate induces cytochromes P450 and aldo-keto reductases in oral cancer cells" @default.
• W2093367519 cites W1660567315 @default.
• W2093367519 cites W1798315186 @default.
• W2093367519 cites W1926290889 @default.
• W2093367519 cites W1965077276 @default.
• W2093367519 cites W1972850783 @default.
• W2093367519 cites W1975669691 @default.
• W2093367519 cites W2008618763 @default.
• W2093367519 cites W2016081901 @default.
• W2093367519 cites W2017818911 @default.
• W2093367519 cites W2027548206 @default.
• W2093367519 cites W2030607204 @default.
• W2093367519 cites W2032791321 @default.
• W2093367519 cites W2038523895 @default.
• W2093367519 cites W2045040068 @default.
• W2093367519 cites W2045931107 @default.
• W2093367519 cites W2055084808 @default.
• W2093367519 cites W2080758266 @default.
• W2093367519 cites W2087423835 @default.
• W2093367519 cites W2099433520 @default.
• W2093367519 cites W2100972980 @default.
• W2093367519 cites W2101157260 @default.
• W2093367519 cites W2107277218 @default.
• W2093367519 cites W2114629114 @default.
• W2093367519 cites W2121030616 @default.
• W2093367519 cites W2125237084 @default.
• W2093367519 cites W2129277308 @default.
• W2093367519 cites W2136979398 @default.
• W2093367519 cites W2137612234 @default.
• W2093367519 cites W2145091158 @default.
• W2093367519 cites W2150285104 @default.
• W2093367519 cites W2152918038 @default.
• W2093367519 cites W2153070836 @default.
• W2093367519 cites W2153625286 @default.
• W2093367519 cites W2164531086 @default.
• W2093367519 cites W2170423316 @default.
• W2093367519 cites W2192080449 @default.
• W2093367519 cites W2197835777 @default.
• W2093367519 cites W2278105335 @default.
• W2093367519 cites W2398115906 @default.
• W2093367519 cites W4235751728 @default.
• W2093367519 cites W4372097243 @default.
• W2093367519 doi "https://doi.org/10.1016/j.toxlet.2006.03.008" @default.
• W2093367519 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5774676" @default.
• W2093367519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16713138" @default.
• W2093367519 hasPublicationYear "2006" @default.
• W2093367519 type Work @default.
• W2093367519 sameAs 2093367519 @default.
• W2093367519 citedByCount "127" @default.
• W2093367519 countsByYear W20933675192012 @default.
• W2093367519 countsByYear W20933675192013 @default.
• W2093367519 countsByYear W20933675192014 @default.
• W2093367519 countsByYear W20933675192015 @default.
• W2093367519 countsByYear W20933675192016 @default.
• W2093367519 countsByYear W20933675192017 @default.
• W2093367519 countsByYear W20933675192018 @default.
• W2093367519 countsByYear W20933675192019 @default.
• W2093367519 countsByYear W20933675192021 @default.
• W2093367519 countsByYear W20933675192022 @default.
• W2093367519 countsByYear W20933675192023 @default.
• W2093367519 crossrefType "journal-article" @default.
• W2093367519 hasAuthorship W2093367519A5000392815 @default.
• W2093367519 hasAuthorship W2093367519A5046937172 @default.
• W2093367519 hasAuthorship W2093367519A5057642803 @default.
• W2093367519 hasAuthorship W2093367519A5066992396 @default.
• W2093367519 hasAuthorship W2093367519A5077562768 @default.
• W2093367519 hasAuthorship W2093367519A5087581002 @default.
• W2093367519 hasBestOaLocation W20933675192 @default.
• W2093367519 hasConcept C104317684 @default.
• W2093367519 hasConcept C114246631 @default.
• W2093367519 hasConcept C127716648 @default.
• W2093367519 hasConcept C143425029 @default.
• W2093367519 hasConcept C1491633281 @default.
• W2093367519 hasConcept C150194340 @default.
• W2093367519 hasConcept C153911025 @default.
• W2093367519 hasConcept C155701950 @default.
• W2093367519 hasConcept C181199279 @default.
• W2093367519 hasConcept C18431079 @default.
• W2093367519 hasConcept C186836561 @default.
• W2093367519 hasConcept C502942594 @default.
• W2093367519 hasConcept C526171541 @default.
• W2093367519 hasConcept C54355233 @default.
• W2093367519 hasConcept C552990157 @default.
• W2093367519 hasConcept C55493867 @default.
• W2093367519 hasConcept C555283112 @default.
• W2093367519 hasConcept C81885089 @default.
• W2093367519 hasConcept C8415881 @default.
• W2093367519 hasConcept C86803240 @default.

• next