Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093370229> ?p ?o ?g. }
- W2093370229 endingPage "545" @default.
- W2093370229 startingPage "535" @default.
- W2093370229 abstract "Dietary exposure to aflatoxin B(1) (AFB(1)) is associated with an increased incidence of hepatocellular carcinoma (HCC), especially in populations in which exposure to hepatitis B virus (HBV) is a common occurrence. Most HCC samples from people living where HBV is prevalent have one striking mutational hotspot: a GC-->TA transversion at the third position of codon 249 of the p53 gene. In this review, the chemical reaction of an electrophilic derivative of aflatoxin with specific DNA sequences is examined, along with the types of mutations caused by AFB(1) and the sequence context dependence of those mutations. An attempt is made to assign the source of these mutations to specific chemical forms of AFB(1)-DNA damage. In addition, epidemiological and experimental data are examined regarding the synergistic effects of AFB(1) and HBV on HCC formation and the predominance of one hotspot GC-->TA transversion in the p53 gene of affected individuals." @default.
- W2093370229 created "2016-06-24" @default.
- W2093370229 creator A5008634105 @default.
- W2093370229 creator A5009785229 @default.
- W2093370229 creator A5024469291 @default.
- W2093370229 creator A5074353761 @default.
- W2093370229 date "2001-04-01" @default.
- W2093370229 modified "2023-10-17" @default.
- W2093370229 title "The chemistry and biology of aflatoxin B1: from mutational spectrometry to carcinogenesis" @default.
- W2093370229 cites W1480852720 @default.
- W2093370229 cites W1964501820 @default.
- W2093370229 cites W1965912307 @default.
- W2093370229 cites W1969148117 @default.
- W2093370229 cites W1969149902 @default.
- W2093370229 cites W1970848975 @default.
- W2093370229 cites W1973368924 @default.
- W2093370229 cites W1973966975 @default.
- W2093370229 cites W1975510750 @default.
- W2093370229 cites W1976807459 @default.
- W2093370229 cites W1977868546 @default.
- W2093370229 cites W1979871569 @default.
- W2093370229 cites W1981601976 @default.
- W2093370229 cites W1983315772 @default.
- W2093370229 cites W1985113590 @default.
- W2093370229 cites W1985747524 @default.
- W2093370229 cites W1987536971 @default.
- W2093370229 cites W1991494214 @default.
- W2093370229 cites W1991715856 @default.
- W2093370229 cites W1992719829 @default.
- W2093370229 cites W1993813448 @default.
- W2093370229 cites W1995966539 @default.
- W2093370229 cites W1996201492 @default.
- W2093370229 cites W1997450951 @default.
- W2093370229 cites W2002155277 @default.
- W2093370229 cites W2003040261 @default.
- W2093370229 cites W2003694128 @default.
- W2093370229 cites W2003941698 @default.
- W2093370229 cites W2008825737 @default.
- W2093370229 cites W2012554636 @default.
- W2093370229 cites W2015221530 @default.
- W2093370229 cites W2015519364 @default.
- W2093370229 cites W2019485670 @default.
- W2093370229 cites W2019981881 @default.
- W2093370229 cites W2021491682 @default.
- W2093370229 cites W2024621231 @default.
- W2093370229 cites W2025800596 @default.
- W2093370229 cites W2031555982 @default.
- W2093370229 cites W2031776743 @default.
- W2093370229 cites W2032833465 @default.
- W2093370229 cites W2035794058 @default.
- W2093370229 cites W2036776010 @default.
- W2093370229 cites W2037490869 @default.
- W2093370229 cites W2042939638 @default.
- W2093370229 cites W2044688997 @default.
- W2093370229 cites W2047431159 @default.
- W2093370229 cites W2047810781 @default.
- W2093370229 cites W2048652058 @default.
- W2093370229 cites W2049510877 @default.
- W2093370229 cites W2049962121 @default.
- W2093370229 cites W2051191795 @default.
- W2093370229 cites W2052997487 @default.
- W2093370229 cites W2053618719 @default.
- W2093370229 cites W2054850562 @default.
- W2093370229 cites W2055773431 @default.
- W2093370229 cites W2056570769 @default.
- W2093370229 cites W2057791682 @default.
- W2093370229 cites W2060447942 @default.
- W2093370229 cites W2063970976 @default.
- W2093370229 cites W2064752311 @default.
- W2093370229 cites W2068040627 @default.
- W2093370229 cites W2068884609 @default.
- W2093370229 cites W2070394784 @default.
- W2093370229 cites W2071697240 @default.
- W2093370229 cites W2075276157 @default.
- W2093370229 cites W2075932136 @default.
- W2093370229 cites W2078613607 @default.
- W2093370229 cites W2079490655 @default.
- W2093370229 cites W2080631986 @default.
- W2093370229 cites W2082465255 @default.
- W2093370229 cites W2083514254 @default.
- W2093370229 cites W2089105114 @default.
- W2093370229 cites W2090547063 @default.
- W2093370229 cites W2091723114 @default.
- W2093370229 cites W2092802559 @default.
- W2093370229 cites W2094169065 @default.
- W2093370229 cites W2097432692 @default.
- W2093370229 cites W2101140330 @default.
- W2093370229 cites W2101518009 @default.
- W2093370229 cites W2107248281 @default.
- W2093370229 cites W2110603834 @default.
- W2093370229 cites W2115535498 @default.
- W2093370229 cites W2115700155 @default.
- W2093370229 cites W2119526433 @default.
- W2093370229 cites W2126284695 @default.
- W2093370229 cites W2138100316 @default.
- W2093370229 cites W2140889959 @default.
- W2093370229 cites W2143778153 @default.
- W2093370229 cites W2143984053 @default.