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• W2093371304 abstract "Inactivation of the retinoblastoma protein (pRB) is a hallmark of human cancer. Accordingly the RB pathway has been extensively studied in mammals, flies and worms, but mostly in the context of cell cycle entry. The means by which RB proteins regulate differentiation and the transcription of genes involved in differentiation and development is less well understood. We have examined how Drosophila RB proteins regulate differentiation-specific genes in proliferating cells. We found that the mechanism of repression differs from what has been observed at cell cycle regulated genes (Figure 1). Two different chromatin modifications present at different locations contribute to the repression of such genes. We argue that this represents a novel mechanism of repression and that this type of regulation by RB proteins warrants further attention." @default.
• W2093371304 created "2016-06-24" @default.
• W2093371304 creator A5002233160 @default.
• W2093371304 date "2011-04-01" @default.
• W2093371304 modified "2023-09-23" @default.
• W2093371304 title "RB regulation of developmental transcriptional programs" @default.
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• W2093371304 doi "https://doi.org/10.4161/fly.5.2.14187" @default.
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