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- W2093371567 abstract "As a continuation of our previous work on oral mucosal adhesive tablets for the administration of insulin and for treatment of aphtous stomatitis, we have investigated a similar type of dosage form using hydroxypropyl cellulose, Carbopol and lidocaine of a model drug for the treatment of toothache by applying the system to the human gingiva. It may be expected that this dosage form affords a prolonged anesthetic action. Next, we have formulated an adhesive gingival plaster which contains 50 μg of prostaglandin F2α (PGF2α) for the facilitation of tooth movement. A study using monkeys showed that daily application of the plasters accelerates the orthodontic process, and thereby reduces the time required for the tooth movement. Additionally, in order to investigate the tissue distribution of the active ingredient, plasters containing 14C-labeled PGF2α were applied to the cheek pouches of hamsters. Autoradiographic, histologic examination of the surrounding tissue reveals that the labeled component had distributed in connective tissues and muscularis, and remained in situ for 8 hours after patch application. No irritation of the mucosal surfaces in any studies performed so far was observed." @default.
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- W2093371567 date "1987-12-01" @default.
- W2093371567 modified "2023-10-06" @default.
- W2093371567 title "Buccal/gingival drug delivery systems" @default.
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- W2093371567 doi "https://doi.org/10.1016/0168-3659(87)90088-5" @default.
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