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- W2093372015 abstract "Paroxetine is a potent novel selective serotonin (5-HT) reuptake inhibitor antidepressant (SSRI). As in other SSR! its antidepressant efficacy was tested against placebo and tricyclic antidepressants. This randomized double-blind study was carried out to evaluate the efficacy and safety of peroxetine (PAR) and fiuoxetine (FIX) in a 6.week treatment of depressed outpatients who met DSM-ill-R criteria for major depressive disorder. Inclusion criteria required patients to be of both sexes, 18 to 65 years old and have a HAM-D score > 18 in the first 17 items. Exclusion criteria were: other psychiatric disorders, relevant medical diseases, pregnancy or lactation, other psychopharmacological treatment and/or being in psychotherapy. After a one week washout period, patients were randomized to 20 mg of PAR (N.,60) or FIX (N,,60). Efficacy and safety were assessed with HAM-D, and Clinical Global Impression (CGi) scales. Patients on PAR were older (43 + DS ! !.0 years) than those on FIX (38+ 10.9 years). The analysis of changes in the HAM-D and CG! showed, in both groups of patients, a significant improvement from day 14, with an even greater improvement until day 42 of treatment (p¢0.05). However, at day 14 patients on PAR showed a decrease in 50% of HAM-D scale items against only 13% for patients on FIX (lg0.05). Six patients (20%) on FLX and 3(10%) on PAR finished the treatment prematurely. Even though PAR and FIX were equally effective antidepressant treatments in this study, depressive outpatients seemed to improve faster with PAR. Other studies comparing SSRI need to be done to corroborate our results." @default.
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- W2093372015 date "1994-05-01" @default.
- W2093372015 modified "2023-09-24" @default.
- W2093372015 title "A double-blind study with paroxetine vs fluoxetine in depressive patients" @default.
- W2093372015 doi "https://doi.org/10.1016/0006-3223(94)90880-x" @default.
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