FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093377824> ?p ?o ?g. }

• W2093377824 endingPage "1253" @default.
• W2093377824 startingPage "1247" @default.
• W2093377824 abstract "1. The effects of protamine on the rabbit isolated small mesenteric artery were investigated both in the presence and in the absence of heparin, by the isometric tension-recording method. 2. The dissociation constant for the binding of heparin to protamine has never been previously reported, so in order to minimize the effects of protamine, known to have a vasodilator action, and to examine only the effects of a heparin-protamine complex, the experiments with heparin were performed in the presence of high concentrations of heparin (21-700 u ml-1), concentrations at which heparin itself does not affect the vascular tone. 3. Protamine (15-500 micrograms ml-1), in the absence of heparin, was found to inhibit (P < 0.05) noradrenaline (1 microM)-induced contractions both in endothelium-intact and in endothelium-denuded tissues. 4. Such vasodilator action of protamine in either endothelium-intact or -denuded tissues continued, even in the presence of excess heparin at a heparin/protamine (H/P) ratio of 1.4 u micrograms -1, but was almost completely blocked in the presence of a much greater excess of heparin (H/P ratio > or = 4.7 u micrograms -1): heparin was present both before and during the application of protamine. 5. The vasodilator action of protamine in the absence of heparin was prolonged both in the endothelium-intact and -denuded tissues after protamine had been washed out from the bath with Krebs solution. Although this washing out with a Krebs solution containing excess heparin (4.7 u ml-1) readily reversed such prolonged vasodilator action of protamine both in the endothelium-denuded strips and in the endothelium-intact strips which had been pretreated with inhibitors of the endothelium-derived relaxing factor (EDRF) pathway, it did not affect the prolonged vasodilator action of protamine in the endothelium-intact strips which received no pharmacological intervention.6. These results suggest that: (1) only protamine, not a heparin-protamine complex, exerts vasodilator action in vitro; (2) the vasodilator action of protamine presumably has an EDRF-mediated component;and (3) protamine probably exerts its direct vasodilator action without entering the smooth muscle cell." @default.
• W2093377824 created "2016-06-24" @default.
• W2093377824 creator A5050754762 @default.
• W2093377824 creator A5071656611 @default.
• W2093377824 creator A5087002509 @default.
• W2093377824 date "1993-08-01" @default.
• W2093377824 modified "2023-10-16" @default.
• W2093377824 title "Effects of heparin on the vasodilator action of protamine in the rabbit mesenteric artery" @default.
• W2093377824 cites W1481084853 @default.
• W2093377824 cites W1528943412 @default.
• W2093377824 cites W1936333617 @default.
• W2093377824 cites W1966733094 @default.
• W2093377824 cites W1969541470 @default.
• W2093377824 cites W1979940333 @default.
• W2093377824 cites W1994002391 @default.
• W2093377824 cites W2014172541 @default.
• W2093377824 cites W2042039669 @default.
• W2093377824 cites W2048375367 @default.
• W2093377824 cites W2048635427 @default.
• W2093377824 cites W2048914997 @default.
• W2093377824 cites W2050836182 @default.
• W2093377824 cites W2058867655 @default.
• W2093377824 cites W2080003016 @default.
• W2093377824 cites W2087284134 @default.
• W2093377824 cites W2091924005 @default.
• W2093377824 cites W2092643965 @default.
• W2093377824 cites W2094562301 @default.
• W2093377824 cites W2113172341 @default.
• W2093377824 cites W2131154758 @default.
• W2093377824 cites W2142975032 @default.
• W2093377824 cites W2150397487 @default.
• W2093377824 cites W2157626972 @default.
• W2093377824 cites W2169182236 @default.
• W2093377824 cites W2327743808 @default.
• W2093377824 cites W2406131218 @default.
• W2093377824 cites W4293262123 @default.
• W2093377824 doi "https://doi.org/10.1111/j.1476-5381.1993.tb13756.x" @default.
• W2093377824 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2175717" @default.
• W2093377824 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8401936" @default.
• W2093377824 hasPublicationYear "1993" @default.
• W2093377824 type Work @default.
• W2093377824 sameAs 2093377824 @default.
• W2093377824 citedByCount "11" @default.
• W2093377824 crossrefType "journal-article" @default.
• W2093377824 hasAuthorship W2093377824A5050754762 @default.
• W2093377824 hasAuthorship W2093377824A5071656611 @default.
• W2093377824 hasAuthorship W2093377824A5087002509 @default.
• W2093377824 hasBestOaLocation W20933778241 @default.
• W2093377824 hasConcept C120770815 @default.
• W2093377824 hasConcept C126322002 @default.
• W2093377824 hasConcept C134018914 @default.
• W2093377824 hasConcept C185592680 @default.
• W2093377824 hasConcept C2776992346 @default.
• W2093377824 hasConcept C2777557582 @default.
• W2093377824 hasConcept C2779354726 @default.
• W2093377824 hasConcept C2780835560 @default.
• W2093377824 hasConcept C55493867 @default.
• W2093377824 hasConcept C71924100 @default.
• W2093377824 hasConcept C98274493 @default.
• W2093377824 hasConceptScore W2093377824C120770815 @default.
• W2093377824 hasConceptScore W2093377824C126322002 @default.
• W2093377824 hasConceptScore W2093377824C134018914 @default.
• W2093377824 hasConceptScore W2093377824C185592680 @default.
• W2093377824 hasConceptScore W2093377824C2776992346 @default.
• W2093377824 hasConceptScore W2093377824C2777557582 @default.
• W2093377824 hasConceptScore W2093377824C2779354726 @default.
• W2093377824 hasConceptScore W2093377824C2780835560 @default.
• W2093377824 hasConceptScore W2093377824C55493867 @default.
• W2093377824 hasConceptScore W2093377824C71924100 @default.
• W2093377824 hasConceptScore W2093377824C98274493 @default.
• W2093377824 hasIssue "4" @default.
• W2093377824 hasLocation W20933778241 @default.
• W2093377824 hasLocation W20933778242 @default.
• W2093377824 hasLocation W20933778243 @default.
• W2093377824 hasLocation W20933778244 @default.
• W2093377824 hasOpenAccess W2093377824 @default.
• W2093377824 hasPrimaryLocation W20933778241 @default.
• W2093377824 hasRelatedWork W2023619243 @default.
• W2093377824 hasRelatedWork W2073279156 @default.
• W2093377824 hasRelatedWork W2090012320 @default.
• W2093377824 hasRelatedWork W2093377824 @default.
• W2093377824 hasRelatedWork W2159413382 @default.
• W2093377824 hasRelatedWork W2188224560 @default.
• W2093377824 hasRelatedWork W2466474455 @default.
• W2093377824 hasRelatedWork W2748952813 @default.
• W2093377824 hasRelatedWork W4236854246 @default.
• W2093377824 hasRelatedWork W2027795091 @default.
• W2093377824 hasVolume "109" @default.
• W2093377824 isParatext "false" @default.
• W2093377824 isRetracted "false" @default.
• W2093377824 magId "2093377824" @default.
• W2093377824 workType "article" @default.