FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093379500> ?p ?o ?g. }

• W2093379500 abstract "Abstract Background Cell migration plays an essential role in many biological processes, such as cancer metastasis, wound healing and immune response. Cell migration is mediated through protrusion and focal adhesion (FA) assembly, maturation and disassembly. Epidermal growth factor (EGF) is known to enhance migration rate in many cell types; however it is not known how FA maturation, FA dynamics and protrusion dynamics are regulated during EGF-induced migration. Here we use total internal reflection fluorescence (TIRF) microscopy and image analysis to quantify FA properties and protrusion dynamics under different doses of EGF stimulation. Results EGF was found to broaden the distribution of cell migration rates, generating more fast and slow cells. Furthermore, groups based on EGF stimulation condition or cell migration speed were marked by characteristic signatures. When data was binned based on EGF stimulation conditions, FA intensity and FA number per cell showed the largest difference among stimulation groups. FA intensity decreased with increasing EGF concentration and FA number per cell was highest under intermediate stimulation conditions. No difference in protrusion behavior was observed. However, when data was binned based on cell migration speed, FA intensity and not FA number per cell showed the largest difference among groups. FA intensity was lower for fast migrating cells. Additionally, waves of protrusion tended to correlate with fast migrating cells. Conclusions Only a portion of the FA properties and protrusion dynamics that correlate with migration speed, correlate with EGF stimulation condition. Those that do not correlate with EGF stimulation condition constitute the most sensitive output for identifying why cells respond differently to EGF. The idea that EGF can both increase and decrease the migration speed of individual cells in a population has particular relevance to cancer metastasis where the microenvironment can select subpopulations based on some adhesion and protrusion characteristics, leading to a more invasive phenotype as would be seen if all cells responded like an “average” cell." @default.
• W2093379500 created "2016-06-24" @default.
• W2093379500 creator A5071558018 @default.
• W2093379500 creator A5081447259 @default.
• W2093379500 creator A5087200792 @default.
• W2093379500 date "2012-05-11" @default.
• W2093379500 modified "2023-10-14" @default.
• W2093379500 title "Differences in adhesion and protrusion properties correlate with differences in migration speed under EGF stimulation" @default.
• W2093379500 cites W1554194168 @default.
• W2093379500 cites W1922523492 @default.
• W2093379500 cites W1965718349 @default.
• W2093379500 cites W1969754919 @default.
• W2093379500 cites W1969964831 @default.
• W2093379500 cites W1975473523 @default.
• W2093379500 cites W1986263651 @default.
• W2093379500 cites W1987139499 @default.
• W2093379500 cites W1992964109 @default.
• W2093379500 cites W2009024878 @default.
• W2093379500 cites W2010632072 @default.
• W2093379500 cites W2011554530 @default.
• W2093379500 cites W2029695466 @default.
• W2093379500 cites W2034082312 @default.
• W2093379500 cites W2038873938 @default.
• W2093379500 cites W2040561330 @default.
• W2093379500 cites W2041772318 @default.
• W2093379500 cites W2044862408 @default.
• W2093379500 cites W2046167304 @default.
• W2093379500 cites W2047903964 @default.
• W2093379500 cites W2052164164 @default.
• W2093379500 cites W2055798867 @default.
• W2093379500 cites W2056229955 @default.
• W2093379500 cites W2056819482 @default.
• W2093379500 cites W2060207593 @default.
• W2093379500 cites W2066108081 @default.
• W2093379500 cites W2079595896 @default.
• W2093379500 cites W2083275631 @default.
• W2093379500 cites W2087904891 @default.
• W2093379500 cites W2097672376 @default.
• W2093379500 cites W2098414179 @default.
• W2093379500 cites W2099158550 @default.
• W2093379500 cites W2105054044 @default.
• W2093379500 cites W2105181228 @default.
• W2093379500 cites W2105848821 @default.
• W2093379500 cites W2111719518 @default.
• W2093379500 cites W2115048429 @default.
• W2093379500 cites W2115260641 @default.
• W2093379500 cites W2123211561 @default.
• W2093379500 cites W2125644189 @default.
• W2093379500 cites W2126376309 @default.
• W2093379500 cites W2126496496 @default.
• W2093379500 cites W2128350223 @default.
• W2093379500 cites W2133054656 @default.
• W2093379500 cites W2134224050 @default.
• W2093379500 cites W2136624635 @default.
• W2093379500 cites W2141768942 @default.
• W2093379500 cites W2141795987 @default.
• W2093379500 cites W2142111204 @default.
• W2093379500 cites W2146062596 @default.
• W2093379500 cites W2148454908 @default.
• W2093379500 cites W2149667112 @default.
• W2093379500 cites W2153626442 @default.
• W2093379500 cites W2153866594 @default.
• W2093379500 cites W2172048983 @default.
• W2093379500 doi "https://doi.org/10.1186/2046-1682-5-8" @default.
• W2093379500 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3414788" @default.
• W2093379500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22577847" @default.
• W2093379500 hasPublicationYear "2012" @default.
• W2093379500 type Work @default.
• W2093379500 sameAs 2093379500 @default.
• W2093379500 citedByCount "16" @default.
• W2093379500 countsByYear W20933795002013 @default.
• W2093379500 countsByYear W20933795002014 @default.
• W2093379500 countsByYear W20933795002015 @default.
• W2093379500 countsByYear W20933795002017 @default.
• W2093379500 countsByYear W20933795002018 @default.
• W2093379500 countsByYear W20933795002019 @default.
• W2093379500 countsByYear W20933795002020 @default.
• W2093379500 countsByYear W20933795002021 @default.
• W2093379500 crossrefType "journal-article" @default.
• W2093379500 hasAuthorship W2093379500A5071558018 @default.
• W2093379500 hasAuthorship W2093379500A5081447259 @default.
• W2093379500 hasAuthorship W2093379500A5087200792 @default.
• W2093379500 hasBestOaLocation W20933795001 @default.
• W2093379500 hasConcept C120665830 @default.
• W2093379500 hasConcept C121332964 @default.
• W2093379500 hasConcept C12554922 @default.
• W2093379500 hasConcept C126322002 @default.
• W2093379500 hasConcept C137738243 @default.
• W2093379500 hasConcept C1491633281 @default.
• W2093379500 hasConcept C151166631 @default.
• W2093379500 hasConcept C16685009 @default.
• W2093379500 hasConcept C170493617 @default.
• W2093379500 hasConcept C178790620 @default.
• W2093379500 hasConcept C185592680 @default.
• W2093379500 hasConcept C24998067 @default.
• W2093379500 hasConcept C2776362946 @default.
• W2093379500 hasConcept C55493867 @default.
• W2093379500 hasConcept C62112901 @default.
• W2093379500 hasConcept C71924100 @default.
• W2093379500 hasConcept C84416704 @default.

• next