FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093384457> ?p ?o ?g. }

• W2093384457 endingPage "65" @default.
• W2093384457 startingPage "57" @default.
• W2093384457 abstract "Activation of T lymphocytes by pokeweed mitogen (PWM) is strictly monocyte (Mo)-dependent and results in T-cell mitogenesis and interleukin-2 (IL-2) secretion, coupled with an inability to utilize IL-2 due to an impaired expression of functional IL-2 receptor (IL-2R). Such IL-2R impairment could arise in PWM-activated T cells themselves or, alternatively, be the result of Mo-derived influences, as it is known that PWM binds Mo strongly and does not or poorly binds lymphocytes, and Mo becomes rapidly destroyed in PWM-stimulated cultures of blood mononuclear cells or T cells plus Mo. The present study investigated these possibilities. The results show for the first time that desialylation of T lymphocytes strongly increases their PWM-binding capacity and, in addition, overcomes the Mo requirement for PWM to induce T-cell mitogenesis and IL-2 secretion. Such secreted IL-2 levels were even higher that those found in cultures of Mo-dependent PWM-activated T lymphocytes but similarly to the latter, PWM-activated desialylated purified T lymphocytes exhibited negligible high-affinity IL-2 binding capacity and an inability to utilize the IL-2 they produced. These effects were not due to desialylation itself, as indicated by data obtained with peanut agglutinin, a lectin that becomes strongly reactive with desialylated T lymphocytes. The data clearly indicate the existence of PWM-related events capable of impairing the expression of functional IL-2R without affecting IL-2 secretion, and indicate that such events are due to mechanisms arising at the level of PWM-activated T cells themselves." @default.
• W2093384457 created "2016-06-24" @default.
• W2093384457 creator A5022449669 @default.
• W2093384457 creator A5048633203 @default.
• W2093384457 creator A5066012478 @default.
• W2093384457 creator A5085523117 @default.
• W2093384457 creator A5088416570 @default.
• W2093384457 date "1997-01-01" @default.
• W2093384457 modified "2023-09-27" @default.
• W2093384457 title "Desialylation of T lymphocytes overcomes the monocyte dependency of pokeweed mitogen‐induced T‐cell activation" @default.
• W2093384457 cites W1479936766 @default.
• W2093384457 cites W1521592910 @default.
• W2093384457 cites W1528177011 @default.
• W2093384457 cites W1533201237 @default.
• W2093384457 cites W1580018685 @default.
• W2093384457 cites W1582608310 @default.
• W2093384457 cites W1603302118 @default.
• W2093384457 cites W1640418706 @default.
• W2093384457 cites W1937040500 @default.
• W2093384457 cites W1968267004 @default.
• W2093384457 cites W1989686141 @default.
• W2093384457 cites W2008980203 @default.
• W2093384457 cites W2014906810 @default.
• W2093384457 cites W2015315589 @default.
• W2093384457 cites W2028466126 @default.
• W2093384457 cites W2030480585 @default.
• W2093384457 cites W2030797393 @default.
• W2093384457 cites W2034651260 @default.
• W2093384457 cites W2038040665 @default.
• W2093384457 cites W2062444119 @default.
• W2093384457 cites W2133811759 @default.
• W2093384457 cites W2140811910 @default.
• W2093384457 cites W2156966127 @default.
• W2093384457 cites W2168822788 @default.
• W2093384457 cites W2345968243 @default.
• W2093384457 cites W28400838 @default.
• W2093384457 cites W30121632 @default.
• W2093384457 cites W336726211 @default.
• W2093384457 cites W60332838 @default.
• W2093384457 doi "https://doi.org/10.1046/j.1365-2567.1997.00129.x" @default.
• W2093384457 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1456722" @default.
• W2093384457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9038713" @default.
• W2093384457 hasPublicationYear "1997" @default.
• W2093384457 type Work @default.
• W2093384457 sameAs 2093384457 @default.
• W2093384457 citedByCount "10" @default.
• W2093384457 countsByYear W20933844572016 @default.
• W2093384457 countsByYear W20933844572017 @default.
• W2093384457 countsByYear W20933844572018 @default.
• W2093384457 countsByYear W20933844572019 @default.
• W2093384457 crossrefType "journal-article" @default.
• W2093384457 hasAuthorship W2093384457A5022449669 @default.
• W2093384457 hasAuthorship W2093384457A5048633203 @default.
• W2093384457 hasAuthorship W2093384457A5066012478 @default.
• W2093384457 hasAuthorship W2093384457A5085523117 @default.
• W2093384457 hasAuthorship W2093384457A5088416570 @default.
• W2093384457 hasBestOaLocation W20933844572 @default.
• W2093384457 hasConcept C134018914 @default.
• W2093384457 hasConcept C147483822 @default.
• W2093384457 hasConcept C170493617 @default.
• W2093384457 hasConcept C19869320 @default.
• W2093384457 hasConcept C202751555 @default.
• W2093384457 hasConcept C203014093 @default.
• W2093384457 hasConcept C2776090121 @default.
• W2093384457 hasConcept C2777371288 @default.
• W2093384457 hasConcept C2781005381 @default.
• W2093384457 hasConcept C2781184567 @default.
• W2093384457 hasConcept C2992881475 @default.
• W2093384457 hasConcept C47794810 @default.
• W2093384457 hasConcept C49039625 @default.
• W2093384457 hasConcept C55493867 @default.
• W2093384457 hasConcept C79484868 @default.
• W2093384457 hasConcept C86803240 @default.
• W2093384457 hasConcept C8891405 @default.
• W2093384457 hasConcept C95444343 @default.
• W2093384457 hasConceptScore W2093384457C134018914 @default.
• W2093384457 hasConceptScore W2093384457C147483822 @default.
• W2093384457 hasConceptScore W2093384457C170493617 @default.
• W2093384457 hasConceptScore W2093384457C19869320 @default.
• W2093384457 hasConceptScore W2093384457C202751555 @default.
• W2093384457 hasConceptScore W2093384457C203014093 @default.
• W2093384457 hasConceptScore W2093384457C2776090121 @default.
• W2093384457 hasConceptScore W2093384457C2777371288 @default.
• W2093384457 hasConceptScore W2093384457C2781005381 @default.
• W2093384457 hasConceptScore W2093384457C2781184567 @default.
• W2093384457 hasConceptScore W2093384457C2992881475 @default.
• W2093384457 hasConceptScore W2093384457C47794810 @default.
• W2093384457 hasConceptScore W2093384457C49039625 @default.
• W2093384457 hasConceptScore W2093384457C55493867 @default.
• W2093384457 hasConceptScore W2093384457C79484868 @default.
• W2093384457 hasConceptScore W2093384457C86803240 @default.
• W2093384457 hasConceptScore W2093384457C8891405 @default.
• W2093384457 hasConceptScore W2093384457C95444343 @default.
• W2093384457 hasIssue "1" @default.
• W2093384457 hasLocation W20933844571 @default.
• W2093384457 hasLocation W20933844572 @default.
• W2093384457 hasLocation W20933844573 @default.
• W2093384457 hasLocation W20933844574 @default.

• next