Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093391025> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2093391025 endingPage "1742" @default.
- W2093391025 startingPage "1737" @default.
- W2093391025 abstract "The leukocyte common antigen isoforms CD45RA and CD45RO have long been used to discriminate human naive and memory T cells respectively. This model was largely based on the observation that CD45RO+ T cells respond preferentially to and show a higher frequency of precursors specific for recall antigens. However, CD45RA+ T cells have more stringent requirements for stimulation and standard in vitro assays may favour CD45RO+ cells in this respect. We tested the hypothesis that CD45RAf T cells respond poorly to in vitro stimulation with recall antigens because of inadequate stimulation rather than a lack of precursors. Limiting dilution analyses (LDA) for tetanus toxoid (lT)-specific T cells were performed in the presence or absence of exogenous antLCD28 antibody. Addition of antLCD28 yielded no proliferation in the absence of specific antigen. The precursor frequency for lT in the CD4+ CD45RO+ population was –1:4000, while the frequency of CD4+ CD45RA+ T cells specific for lT was 4- to ≫20-fold lower. Addition of anti-CD28 antibody did not significantly alter the apparent precursor frequency for CD45RA+ cells but yielded an enhancement of the value for CD45RA+ cells by 3- to ≫5-fold. No enhancement of antigen-specific proliferation by antLCD28 was observed with CD45RA+ T cells derived from cord blood, although phytohemagglutinin responses of these cells were amplified by CD28 antibody. These results indicate that conventional LDA underestimate the true precursor frequency of antigen-specific cells within the adult CD45RA+ population and support the possibility that a small number of cells revert from a primed (CD45RO+) to an unprimed (CD45RA+) state. The majority of memory T cells, however, appear to reside in the CD45RO+ population" @default.
- W2093391025 created "2016-06-24" @default.
- W2093391025 creator A5009594820 @default.
- W2093391025 creator A5028452183 @default.
- W2093391025 creator A5067292723 @default.
- W2093391025 creator A5086429836 @default.
- W2093391025 date "1996-01-01" @default.
- W2093391025 modified "2023-09-23" @default.
- W2093391025 title "CD4<sup>+</sup>CD45RA<sup>+</sup>T cells from adults respond to recall antigens after CD28 ligation" @default.
- W2093391025 cites W1497403634 @default.
- W2093391025 cites W1565814966 @default.
- W2093391025 cites W1568059997 @default.
- W2093391025 cites W1572305746 @default.
- W2093391025 cites W1928409557 @default.
- W2093391025 cites W1970038233 @default.
- W2093391025 cites W1988515184 @default.
- W2093391025 cites W1999168221 @default.
- W2093391025 cites W2043955812 @default.
- W2093391025 cites W2047125790 @default.
- W2093391025 cites W2055421812 @default.
- W2093391025 cites W2079504732 @default.
- W2093391025 cites W2086847331 @default.
- W2093391025 cites W2087774304 @default.
- W2093391025 cites W2124779570 @default.
- W2093391025 cites W2125650988 @default.
- W2093391025 cites W2136536421 @default.
- W2093391025 cites W2137266943 @default.
- W2093391025 cites W2140202337 @default.
- W2093391025 cites W2148837825 @default.
- W2093391025 cites W2164277825 @default.
- W2093391025 cites W2313196075 @default.
- W2093391025 cites W2358982988 @default.
- W2093391025 cites W564376973 @default.
- W2093391025 cites W70341877 @default.
- W2093391025 cites W2735121830 @default.
- W2093391025 doi "https://doi.org/10.1093/intimm/8.11.1737" @default.
- W2093391025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8943568" @default.
- W2093391025 hasPublicationYear "1996" @default.
- W2093391025 type Work @default.
- W2093391025 sameAs 2093391025 @default.
- W2093391025 citedByCount "48" @default.
- W2093391025 countsByYear W20933910252012 @default.
- W2093391025 countsByYear W20933910252013 @default.
- W2093391025 countsByYear W20933910252016 @default.
- W2093391025 crossrefType "journal-article" @default.
- W2093391025 hasAuthorship W2093391025A5009594820 @default.
- W2093391025 hasAuthorship W2093391025A5028452183 @default.
- W2093391025 hasAuthorship W2093391025A5067292723 @default.
- W2093391025 hasAuthorship W2093391025A5086429836 @default.
- W2093391025 hasBestOaLocation W20933910251 @default.
- W2093391025 hasConcept C147483822 @default.
- W2093391025 hasConcept C148125776 @default.
- W2093391025 hasConcept C153911025 @default.
- W2093391025 hasConcept C159654299 @default.
- W2093391025 hasConcept C167672396 @default.
- W2093391025 hasConcept C185592680 @default.
- W2093391025 hasConcept C203014093 @default.
- W2093391025 hasConcept C2776090121 @default.
- W2093391025 hasConcept C2908647359 @default.
- W2093391025 hasConcept C71924100 @default.
- W2093391025 hasConcept C86803240 @default.
- W2093391025 hasConcept C8891405 @default.
- W2093391025 hasConcept C99454951 @default.
- W2093391025 hasConceptScore W2093391025C147483822 @default.
- W2093391025 hasConceptScore W2093391025C148125776 @default.
- W2093391025 hasConceptScore W2093391025C153911025 @default.
- W2093391025 hasConceptScore W2093391025C159654299 @default.
- W2093391025 hasConceptScore W2093391025C167672396 @default.
- W2093391025 hasConceptScore W2093391025C185592680 @default.
- W2093391025 hasConceptScore W2093391025C203014093 @default.
- W2093391025 hasConceptScore W2093391025C2776090121 @default.
- W2093391025 hasConceptScore W2093391025C2908647359 @default.
- W2093391025 hasConceptScore W2093391025C71924100 @default.
- W2093391025 hasConceptScore W2093391025C86803240 @default.
- W2093391025 hasConceptScore W2093391025C8891405 @default.
- W2093391025 hasConceptScore W2093391025C99454951 @default.
- W2093391025 hasIssue "11" @default.
- W2093391025 hasLocation W20933910251 @default.
- W2093391025 hasLocation W20933910252 @default.
- W2093391025 hasOpenAccess W2093391025 @default.
- W2093391025 hasPrimaryLocation W20933910251 @default.
- W2093391025 hasRelatedWork W1974142213 @default.
- W2093391025 hasRelatedWork W2000442621 @default.
- W2093391025 hasRelatedWork W2033739428 @default.
- W2093391025 hasRelatedWork W2040191638 @default.
- W2093391025 hasRelatedWork W2048473435 @default.
- W2093391025 hasRelatedWork W2053424985 @default.
- W2093391025 hasRelatedWork W2092538248 @default.
- W2093391025 hasRelatedWork W2220102944 @default.
- W2093391025 hasRelatedWork W2229562627 @default.
- W2093391025 hasRelatedWork W2574914054 @default.
- W2093391025 hasVolume "8" @default.
- W2093391025 isParatext "false" @default.
- W2093391025 isRetracted "false" @default.
- W2093391025 magId "2093391025" @default.
- W2093391025 workType "article" @default.