FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093398170> ?p ?o ?g. }

• W2093398170 endingPage "53" @default.
• W2093398170 startingPage "41" @default.
• W2093398170 abstract "The matrix (M) protein of vesicular stomatitis virus (VSV) plays significant roles in the replication of VSV through its involvement in the assembly of virus particles as well as by facilitating the evasion of innate host cell defense mechanisms. The presence of methionine at position 51 (M51) of the matrix (M) protein of the VSV Indiana serotype (VSV Ind ) has been proven to be crucial for cell rounding and inhibition of host cell gene expression. The M protein of VSV Ind with the substitution of M51 with arginine (R:M51R) results in the loss of inhibitory effects on host cell gene expression. The VSV Ind expressing the M(M51R) protein became the attractive oncolytic virus which is safer and more tumor-specific because the normal cells can clear the mutant VSV Ind easily but tumor cells are susceptible to the virus because a variety of tumor cells lack innate antiviral activities. We have studied the role of the methionines at positions 48 and 51 of the M protein of the New Jersey serotype of VSV (VSV NJ ) in the induction of cytopathic effects (CPE) and host cell gene expression. We have generated human embryonic kidney 293 cell lines inducibly expressing M proteins with M to R mutations at positions 48 and 51, either separately or together as a double mutant, and examined expression of heat shock protein 70 (HSP70) as an indicator of host cell gene expression. We have also generated recombinant VSV NJ encoding the mutant M proteins M(M48R) or M(M48R + M51R) for the first time and tested for the expression of HSP70 in infected cells. Our results demonstrated that the M51 of VSV NJ M proteins has a major role in cell rounding and in suppressing the host cell gene expression either when the M protein was expressed alone in inducible cell lines or when expressed together with other VSV proteins by the recombinant VSV NJ . Amino acid residue M48 may also have some role in cell rounding and in the inhibitory effects of VSV NJ M, which was demonstrated by the fact that the cell line expressing the double substitution mutant M(M48R + M51R) exhibited the least cytopathic effects and the least inhibitory effect on host cell gene expression." @default.
• W2093398170 created "2016-06-24" @default.
• W2093398170 creator A5009335748 @default.
• W2093398170 creator A5072699056 @default.
• W2093398170 date "2007-01-01" @default.
• W2093398170 modified "2023-09-29" @default.
• W2093398170 title "Matrix protein of VSV New Jersey serotype containing methionine to arginine substitutions at positions 48 and 51 allows near-normal host cell gene expression" @default.
• W2093398170 cites W1540216047 @default.
• W2093398170 cites W1542691850 @default.
• W2093398170 cites W1588006079 @default.
• W2093398170 cites W1876513378 @default.
• W2093398170 cites W1935523902 @default.
• W2093398170 cites W1961390927 @default.
• W2093398170 cites W1969020637 @default.
• W2093398170 cites W1986326110 @default.
• W2093398170 cites W1990565001 @default.
• W2093398170 cites W1999128872 @default.
• W2093398170 cites W2005411001 @default.
• W2093398170 cites W2007925408 @default.
• W2093398170 cites W2014303424 @default.
• W2093398170 cites W2014730746 @default.
• W2093398170 cites W2026512609 @default.
• W2093398170 cites W2029574367 @default.
• W2093398170 cites W2029805529 @default.
• W2093398170 cites W2030952033 @default.
• W2093398170 cites W2032014779 @default.
• W2093398170 cites W2040705986 @default.
• W2093398170 cites W2051519190 @default.
• W2093398170 cites W2072589605 @default.
• W2093398170 cites W2072752869 @default.
• W2093398170 cites W2079199718 @default.
• W2093398170 cites W2087946947 @default.
• W2093398170 cites W2092499288 @default.
• W2093398170 cites W2095537460 @default.
• W2093398170 cites W2096602182 @default.
• W2093398170 cites W2097554949 @default.
• W2093398170 cites W2108807439 @default.
• W2093398170 cites W2114608008 @default.
• W2093398170 cites W2117845552 @default.
• W2093398170 cites W2117847966 @default.
• W2093398170 cites W2124160523 @default.
• W2093398170 cites W2124358132 @default.
• W2093398170 cites W2125922177 @default.
• W2093398170 cites W2127954678 @default.
• W2093398170 cites W2131596778 @default.
• W2093398170 cites W2142271326 @default.
• W2093398170 cites W2142549149 @default.
• W2093398170 cites W2143271622 @default.
• W2093398170 cites W2147334926 @default.
• W2093398170 cites W2150701651 @default.
• W2093398170 cites W2153028137 @default.
• W2093398170 cites W2159453337 @default.
• W2093398170 cites W2159779332 @default.
• W2093398170 cites W2169070569 @default.
• W2093398170 cites W2171167766 @default.
• W2093398170 cites W83140495 @default.
• W2093398170 doi "https://doi.org/10.1016/j.virol.2006.07.022" @default.
• W2093398170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16962155" @default.
• W2093398170 hasPublicationYear "2007" @default.
• W2093398170 type Work @default.
• W2093398170 sameAs 2093398170 @default.
• W2093398170 citedByCount "14" @default.
• W2093398170 countsByYear W20933981702012 @default.
• W2093398170 countsByYear W20933981702013 @default.
• W2093398170 countsByYear W20933981702014 @default.
• W2093398170 countsByYear W20933981702015 @default.
• W2093398170 countsByYear W20933981702020 @default.
• W2093398170 countsByYear W20933981702021 @default.
• W2093398170 crossrefType "journal-article" @default.
• W2093398170 hasAuthorship W2093398170A5009335748 @default.
• W2093398170 hasAuthorship W2093398170A5072699056 @default.
• W2093398170 hasBestOaLocation W20933981701 @default.
• W2093398170 hasConcept C104317684 @default.
• W2093398170 hasConcept C143065580 @default.
• W2093398170 hasConcept C150194340 @default.
• W2093398170 hasConcept C153911025 @default.
• W2093398170 hasConcept C159047783 @default.
• W2093398170 hasConcept C2522874641 @default.
• W2093398170 hasConcept C2779057330 @default.
• W2093398170 hasConcept C54355233 @default.
• W2093398170 hasConcept C68434959 @default.
• W2093398170 hasConcept C81885089 @default.
• W2093398170 hasConcept C82210918 @default.
• W2093398170 hasConcept C86803240 @default.
• W2093398170 hasConcept C95444343 @default.
• W2093398170 hasConceptScore W2093398170C104317684 @default.
• W2093398170 hasConceptScore W2093398170C143065580 @default.
• W2093398170 hasConceptScore W2093398170C150194340 @default.
• W2093398170 hasConceptScore W2093398170C153911025 @default.
• W2093398170 hasConceptScore W2093398170C159047783 @default.
• W2093398170 hasConceptScore W2093398170C2522874641 @default.
• W2093398170 hasConceptScore W2093398170C2779057330 @default.
• W2093398170 hasConceptScore W2093398170C54355233 @default.
• W2093398170 hasConceptScore W2093398170C68434959 @default.
• W2093398170 hasConceptScore W2093398170C81885089 @default.
• W2093398170 hasConceptScore W2093398170C82210918 @default.
• W2093398170 hasConceptScore W2093398170C86803240 @default.
• W2093398170 hasConceptScore W2093398170C95444343 @default.

• next