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- W2093403906 abstract "Stroke is the third cause of mortality and one of most frequent causes of long-term neurological disability, as well as a complex disease that results from the interaction of environmental and genetic factors. The focus on genetics has produced a large number of studies with the objective of revealing the genetic basis of cerebrovascular diseases. Furthermore, pharmacogenetic research has investigated the relation between genetic variability and drug effectiveness/toxicity. This review will examine the implications of pharmacogenetics of stroke; data on antihypertensives, statins, antiplatelets, anticoagulants, and recombinant tissue plasminogen activator will be illustrated. Several polymorphisms have been studied and some have been associated with positive drug-gene interaction on stroke, but the superiority of the genotype-guided approach over the clinical approach has not been proved yet; for this reason, it is not routinely recommended." @default.
- W2093403906 created "2016-06-24" @default.
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- W2093403906 creator A5054783539 @default.
- W2093403906 date "2011-01-01" @default.
- W2093403906 modified "2023-09-27" @default.
- W2093403906 title "Gene-Drug Interaction in Stroke" @default.
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- W2093403906 doi "https://doi.org/10.4061/2011/212485" @default.
- W2093403906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3216369" @default.
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- W2093403906 hasPublicationYear "2011" @default.
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